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Protein

Bis(5'-nucleosyl)-tetraphosphatase, symmetrical

Gene

apaH

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.By similarity

Catalytic activityi

P1,P4-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

BioCyciVCHO:VC0441-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical (EC:3.6.1.41)
Alternative name(s):
Ap4A hydrolase
Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase
Diadenosine tetraphosphatase
Gene namesi
Name:apaH
Ordered Locus Names:VC_0441
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000000584 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001980121 – 269Bis(5'-nucleosyl)-tetraphosphatase, symmetricalAdd BLAST269

Interactioni

Protein-protein interaction databases

STRINGi243277.VC0441

Structurei

3D structure databases

ProteinModelPortaliQ9KUS4
SMRiQ9KUS4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Ap4A hydrolase family.Curated

Phylogenomic databases

eggNOGiENOG4105DDT Bacteria
COG0639 LUCA
KOiK01525
OMAiMPWFDVP

Family and domain databases

CDDicd07422 MPP_ApaH, 1 hit
Gene3Di3.60.21.10, 1 hit
HAMAPiMF_00199 ApaH, 1 hit
InterProiView protein in InterPro
IPR004617 ApaH
IPR004843 Calcineurin-like_PHP_ApaH
IPR029052 Metallo-depent_PP-like
PfamiView protein in Pfam
PF00149 Metallophos, 1 hit
PIRSFiPIRSF000903 B5n-ttraPtase_sm, 1 hit
TIGRFAMsiTIGR00668 apaH, 1 hit

Sequencei

Sequence statusi: Complete.

Q9KUS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANYIVGDIQ GCFDELQQLL KQAEFNSQLD TLWFAGDLVA RGPKSLETLR
60 70 80 90 100
FVYQLGDAAR VVLGNHDLHL LSVALGHHSA KRRDQTQAVL DAPDAAPLLD
110 120 130 140 150
WLRQQPLLAE HQEFVLCHAG ISPQWDLATA RQAAQEVESV LRSPEWSTLI
160 170 180 190 200
EQMYSDQPDA WHPTLQGIDR LRYIVNAFTR MRFCFPDGRL DMQCKLPPKE
210 220 230 240 250
VTDGSLLPWF QLPQRIALEK TVIFGHWAAL EGYVSETVIG LDTGCVWGGT
260
LTMLRWEDKH YFSQAALPA
Length:269
Mass (Da):30,408
Last modified:October 1, 2000 - v1
Checksum:iE6D87A1C474D45BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA Translation: AAF93614.1
PIRiH82322
RefSeqiNP_230095.1, NC_002505.1
WP_000035032.1, NC_002505.1

Genome annotation databases

EnsemblBacteriaiAAF93614; AAF93614; VC_0441
GeneIDi2615702
KEGGivch:VC0441
PATRICifig|243277.26.peg.415

Similar proteinsi

Entry informationi

Entry nameiAPAH_VIBCH
AccessioniPrimary (citable) accession number: Q9KUS4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health