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Protein

Bis(5'-nucleosyl)-tetraphosphatase, symmetrical

Gene

apaH

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP.By similarity

Catalytic activityi

P1,P(4)-bis(5'-adenosyl) tetraphosphate + H2O = 2 ADP.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

BioCyciVCHO:VC0441-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Bis(5'-nucleosyl)-tetraphosphatase, symmetrical (EC:3.6.1.41)
Alternative name(s):
Ap4A hydrolase
Diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase
Diadenosine tetraphosphatase
Gene namesi
Name:apaH
Ordered Locus Names:VC_0441
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000000584 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001980121 – 269Bis(5'-nucleosyl)-tetraphosphatase, symmetricalAdd BLAST269

Interactioni

Protein-protein interaction databases

STRINGi243277.VC0441.

Structurei

3D structure databases

ProteinModelPortaliQ9KUS4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Ap4A hydrolase family.Curated

Phylogenomic databases

eggNOGiENOG4105DDT. Bacteria.
COG0639. LUCA.
KOiK01525.
OMAiINAFTRM.

Family and domain databases

CDDicd07422. MPP_ApaH. 1 hit.
Gene3Di3.60.21.10. 2 hits.
HAMAPiMF_00199. ApaH. 1 hit.
InterProiIPR004617. ApaH.
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000903. B5n-ttraPtase_sm. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
TIGRFAMsiTIGR00668. apaH. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9KUS4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MANYIVGDIQ GCFDELQQLL KQAEFNSQLD TLWFAGDLVA RGPKSLETLR
60 70 80 90 100
FVYQLGDAAR VVLGNHDLHL LSVALGHHSA KRRDQTQAVL DAPDAAPLLD
110 120 130 140 150
WLRQQPLLAE HQEFVLCHAG ISPQWDLATA RQAAQEVESV LRSPEWSTLI
160 170 180 190 200
EQMYSDQPDA WHPTLQGIDR LRYIVNAFTR MRFCFPDGRL DMQCKLPPKE
210 220 230 240 250
VTDGSLLPWF QLPQRIALEK TVIFGHWAAL EGYVSETVIG LDTGCVWGGT
260
LTMLRWEDKH YFSQAALPA
Length:269
Mass (Da):30,408
Last modified:October 1, 2000 - v1
Checksum:iE6D87A1C474D45BB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF93614.1.
PIRiH82322.
RefSeqiNP_230095.1. NC_002505.1.
WP_000035032.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF93614; AAF93614; VC_0441.
GeneIDi2615702.
KEGGivch:VC0441.
PATRICi20079961. VBIVibCho83274_0415.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF93614.1.
PIRiH82322.
RefSeqiNP_230095.1. NC_002505.1.
WP_000035032.1. NC_002505.1.

3D structure databases

ProteinModelPortaliQ9KUS4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243277.VC0441.

Protocols and materials databases

DNASUi2615702.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF93614; AAF93614; VC_0441.
GeneIDi2615702.
KEGGivch:VC0441.
PATRICi20079961. VBIVibCho83274_0415.

Phylogenomic databases

eggNOGiENOG4105DDT. Bacteria.
COG0639. LUCA.
KOiK01525.
OMAiINAFTRM.

Enzyme and pathway databases

BioCyciVCHO:VC0441-MONOMER.

Family and domain databases

CDDicd07422. MPP_ApaH. 1 hit.
Gene3Di3.60.21.10. 2 hits.
HAMAPiMF_00199. ApaH. 1 hit.
InterProiIPR004617. ApaH.
IPR004843. Calcineurin-like_PHP_ApaH.
IPR029052. Metallo-depent_PP-like.
[Graphical view]
PfamiPF00149. Metallophos. 1 hit.
[Graphical view]
PIRSFiPIRSF000903. B5n-ttraPtase_sm. 1 hit.
SUPFAMiSSF56300. SSF56300. 1 hit.
TIGRFAMsiTIGR00668. apaH. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiAPAH_VIBCH
AccessioniPrimary (citable) accession number: Q9KUS4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 27, 2002
Last sequence update: October 1, 2000
Last modified: November 30, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.