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Protein

Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

Gene

glmS

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.UniRule annotation

Catalytic activityi

L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei2Nucleophile; for GATase activityUniRule annotation1
Active sitei605For Fru-6P isomerization activityUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminotransferase, Transferase

Enzyme and pathway databases

BioCyciVCHO:VC0487-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]UniRule annotation (EC:2.6.1.16UniRule annotation)
Alternative name(s):
D-fructose-6-phosphate amidotransferaseUniRule annotation
GFATUniRule annotation
Glucosamine-6-phosphate synthaseUniRule annotation
Hexosephosphate aminotransferaseUniRule annotation
L-glutamine--D-fructose-6-phosphate amidotransferaseUniRule annotation
Gene namesi
Name:glmSUniRule annotation
Ordered Locus Names:VC_0487
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000000584 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedUniRule annotation
ChainiPRO_00001354082 – 610Glutamine--fructose-6-phosphate aminotransferase [isomerizing]Add BLAST609

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi243277.VC0487.

Structurei

3D structure databases

ProteinModelPortaliQ9KUM8.
SMRiQ9KUM8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 218Glutamine amidotransferase type-2UniRule annotationAdd BLAST217
Domaini286 – 426SIS 1UniRule annotationAdd BLAST141
Domaini459 – 600SIS 2UniRule annotationAdd BLAST142

Keywords - Domaini

Glutamine amidotransferase, Repeat

Phylogenomic databases

eggNOGiENOG4105C46. Bacteria.
COG0449. LUCA.
KOiK00820.
OMAiASEYRYA.

Family and domain databases

CDDicd05008. SIS_GlmS_GlmD_1. 1 hit.
cd05009. SIS_GlmS_GlmD_2. 1 hit.
Gene3Di3.60.20.10. 1 hit.
HAMAPiMF_00164. GlmS. 1 hit.
InterProiView protein in InterPro
IPR017932. GATase_2_dom.
IPR035466. GlmS/AgaS_SIS.
IPR035490. GlmS/FrlB_SIS.
IPR005855. GlmS_trans.
IPR029055. Ntn_hydrolases_N.
IPR001347. SIS.
PANTHERiPTHR10937:SF15. PTHR10937:SF15. 1 hit.
PfamiView protein in Pfam
PF01380. SIS. 2 hits.
SUPFAMiSSF56235. SSF56235. 1 hit.
TIGRFAMsiTIGR01135. glmS. 1 hit.
PROSITEiView protein in PROSITE
PS51278. GATASE_TYPE_2. 1 hit.
PS51464. SIS. 2 hits.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9KUM8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MCGIVGAVAQ RDVAEILVQG LRRLEYRGYD SAGVAVVDSD KQLTRLRRLG
60 70 80 90 100
KVQELADAVE AAQVAGGTGI AHTRWATHGE PSEINAHPHI SGDITVVHNG
110 120 130 140 150
IIENHEMLRT MLQDRGYVFT SQTDTEVIAH LVEWELRSAS SLLEAVQTTV
160 170 180 190 200
KQLTGAYGTV VMDRNDPSRL VVARSGSPIV IGFGIGENFL ASDQLALLNV
210 220 230 240 250
TRRFMYLEEG DVAEMTRRDV RVFDALGQPV QREISESNLE HDAADKGHYR
260 270 280 290 300
HYMQKEIFEQ PKALINTMEG RITHDCVVVE SIGVHAAEIL AKVEHVQIVA
310 320 330 340 350
CGTSYNAGMT ARYWFESLAG VSCDVEIASE FRYRKFVTRP NSLLITLSQS
360 370 380 390 400
GETADTLAAL RLAKEKGYMA AMTICNVAGS SLVRESDFAF MTRAGTEIGV
410 420 430 440 450
ASTKAFTTQL VTLLMLVTAL GKQQQRIGRE LEAEIVHALH QLPKQIETAL
460 470 480 490 500
SFEKQIETLA EDFADKHHTL FLGRGEYYPI AVEASLKLKE ISYIHAEAYA
510 520 530 540 550
AGELKHGPLA LIDADMPVVV VAPSNELLEK LKSNIEEVRA RGGLLYVFAD
560 570 580 590 600
EVAGFEADET MKIIAMPHVS EIVAPIYYTI PMQLLSYHVA LIKGTDVDQP
610
RNLAKAVTVE
Length:610
Mass (Da):67,099
Last modified:January 23, 2007 - v3
Checksum:i56D73990D0083383
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF93660.1.
PIRiE82316.
RefSeqiNP_230141.1. NC_002505.1.
WP_000334125.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF93660; AAF93660; VC_0487.
GeneIDi2615281.
KEGGivch:VC0487.
PATRICifig|243277.26.peg.460.

Similar proteinsi

Entry informationi

Entry nameiGLMS_VIBCH
AccessioniPrimary (citable) accession number: Q9KUM8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: January 23, 2007
Last modified: August 30, 2017
This is version 100 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome