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Q9KUG4

- LUXS_VIBCH

UniProt

Q9KUG4 - LUXS_VIBCH

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Protein

S-ribosylhomocysteine lyase

Gene
luxS, VC_0557
Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD) By similarity.UniRule annotation

Catalytic activityi

S-(5-deoxy-D-ribos-5-yl)-L-homocysteine = L-homocysteine + (4S)-4,5-dihydroxypentan-2,3-dione.UniRule annotation

Cofactori

Binds 1 iron ion per subunit By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi54 – 541Iron By similarity
Metal bindingi58 – 581Iron By similarity
Metal bindingi128 – 1281Iron By similarity

GO - Molecular functioni

  1. iron ion binding Source: InterPro
  2. S-ribosylhomocysteine lyase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. quorum sensing Source: TIGR
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Autoinducer synthesis, Quorum sensing

Keywords - Ligandi

Iron, Metal-binding

Enzyme and pathway databases

BioCyciVCHO:VC0557-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
S-ribosylhomocysteine lyase (EC:4.4.1.21)
Alternative name(s):
AI-2 synthesis protein
Autoinducer-2 production protein LuxS
Gene namesi
Name:luxS
Ordered Locus Names:VC_0557
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 172171S-ribosylhomocysteine lyaseUniRule annotationPRO_0000172274Add
BLAST

Proteomic databases

PRIDEiQ9KUG4.

Interactioni

Subunit structurei

Homodimer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi243277.VC0557.

Structurei

3D structure databases

ProteinModelPortaliQ9KUG4.
SMRiQ9KUG4. Positions 3-161.

Family & Domainsi

Sequence similaritiesi

Belongs to the LuxS family.

Phylogenomic databases

eggNOGiCOG1854.
KOiK07173.
OMAiYPARNLA.
OrthoDBiEOG68WRBM.

Family and domain databases

Gene3Di3.30.1360.80. 1 hit.
HAMAPiMF_00091. LuxS.
InterProiIPR011249. Metalloenz_LuxS/M16.
IPR003815. S-ribosylhomocysteinase.
[Graphical view]
PfamiPF02664. LuxS. 1 hit.
[Graphical view]
PIRSFiPIRSF006160. AI2. 1 hit.
PRINTSiPR01487. LUXSPROTEIN.
ProDomiPD013172. S-ribosylhomocysteinase. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF63411. SSF63411. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9KUG4-1 [UniParc]FASTAAdd to Basket

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MPLLDSFTVD HTRMNAPAVR VAKTMQTPKG DTITVFDLRF TMPNKDILSE    50
RGIHTLEHLY AGFMRNHLNG SQVEIIDISP MGCRTGFYMS LIGAPTEQQV 100
AQAWLAAMQD VLKVESQEQI PELNEYQCGT AAMHSLEEAK AIAKNVIAAG 150
ISVNRNDELA LPESMLNELK VH 172
Length:172
Mass (Da):19,081
Last modified:January 23, 2007 - v3
Checksum:i6D481F831DBB65AF
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003852 Genomic DNA. Translation: AAF93725.1.
PIRiF82309.
RefSeqiNP_230208.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF93725; AAF93725; VC_0557.
GeneIDi2615234.
KEGGivch:VC0557.
PATRICi20080232. VBIVibCho83274_0532.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003852 Genomic DNA. Translation: AAF93725.1 .
PIRi F82309.
RefSeqi NP_230208.1. NC_002505.1.

3D structure databases

ProteinModelPortali Q9KUG4.
SMRi Q9KUG4. Positions 3-161.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243277.VC0557.

Proteomic databases

PRIDEi Q9KUG4.

Protocols and materials databases

DNASUi 2615234.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF93725 ; AAF93725 ; VC_0557 .
GeneIDi 2615234.
KEGGi vch:VC0557.
PATRICi 20080232. VBIVibCho83274_0532.

Phylogenomic databases

eggNOGi COG1854.
KOi K07173.
OMAi YPARNLA.
OrthoDBi EOG68WRBM.

Enzyme and pathway databases

BioCyci VCHO:VC0557-MONOMER.

Family and domain databases

Gene3Di 3.30.1360.80. 1 hit.
HAMAPi MF_00091. LuxS.
InterProi IPR011249. Metalloenz_LuxS/M16.
IPR003815. S-ribosylhomocysteinase.
[Graphical view ]
Pfami PF02664. LuxS. 1 hit.
[Graphical view ]
PIRSFi PIRSF006160. AI2. 1 hit.
PRINTSi PR01487. LUXSPROTEIN.
ProDomi PD013172. S-ribosylhomocysteinase. 1 hit.
[Graphical view ] [Entries sharing at least one domain ]
SUPFAMi SSF63411. SSF63411. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.

Entry informationi

Entry nameiLUXS_VIBCH
AccessioniPrimary (citable) accession number: Q9KUG4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2002
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 78 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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