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Q9KU97 (GSA_VIBCH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 95. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamate-1-semialdehyde 2,1-aminomutase

Short name=GSA
EC=5.4.3.8
Alternative name(s):
Glutamate-1-semialdehyde aminotransferase
Short name=GSA-AT
Gene names
Name:hemL
Ordered Locus Names:VC_0626
OrganismVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) [Reference proteome] [HAMAP]
Taxonomic identifier243277 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length432 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

(S)-4-amino-5-oxopentanoate = 5-aminolevulinate. HAMAP-Rule MF_00375

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00375

Pathway

Porphyrin-containing compound metabolism; protoporphyrin-IX biosynthesis; 5-aminolevulinate from L-glutamyl-tRNA(Glu): step 2/2. HAMAP-Rule MF_00375

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00375

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00375.

Sequence similarities

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 432432Glutamate-1-semialdehyde 2,1-aminomutase HAMAP-Rule MF_00375
PRO_0000120463

Amino acid modifications

Modified residue2651N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9KU97 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 963BD21BE460C714

FASTA43246,182
        10         20         30         40         50         60 
MTKSAELYQK AQTTIPGGVN SPVRAFNGVG GSPIFIDRAD GALIFDADGK AYIDYVGSWG 

        70         80         90        100        110        120 
PMILGHNHAV IREAVIQAAQ RGLSFGAPTE MEITMAELVS ELVPSMEQLR MVNSGTEATM 

       130        140        150        160        170        180 
SAIRLARGYT GRDKIIKFEG CYHGHADSLL VKAGSGALTL GQPSSPGVPA DFAKHTLTAR 

       190        200        210        220        230        240 
FNDLDSVREL FAANQGEIAC IIVEPVAGNM NCIPPVEGFH EGLREICDQE GALLIFDEVM 

       250        260        270        280        290        300 
TGFRVALGGA QAHYNIKPDL TTLGKVIGGG MPVGAFGGRR EVMQYIAPTG PVYQAGTLSG 

       310        320        330        340        350        360 
NPIAMAAGYA CLNLLREEGN EKRLAAKTKQ LADGFKSLAD QHGIPLLVHQ VGGMFGFFFT 

       370        380        390        400        410        420 
EQETVTCYED VARCDVERFK RFFHLMLQHG VYLAPSAFEA SFTSLAHGSK EIEATLEAAD 

       430 
RSFAILAAEA KA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE003852 Genomic DNA. Translation: AAF93792.1.
PIRE82300.
RefSeqNP_230275.1. NC_002505.1.

3D structure databases

ProteinModelPortalQ9KU97.
SMRQ9KU97. Positions 2-422.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243277.VC0626.

Proteomic databases

PRIDEQ9KU97.

Protocols and materials databases

DNASU2615414.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF93792; AAF93792; VC_0626.
GeneID2615414.
KEGGvch:VC0626.
PATRIC20080359. VBIVibCho83274_0595.

Phylogenomic databases

eggNOGCOG0001.
KOK01845.
OMARAIKPYP.
OrthoDBEOG6QVRHN.

Enzyme and pathway databases

BioCycVCHO:VC0626-MONOMER.
UniPathwayUPA00251; UER00317.

Family and domain databases

Gene3D3.40.640.10. 1 hit.
3.90.1150.10. 2 hits.
HAMAPMF_00375. HemL_aminotrans_3.
InterProIPR004639. 4pyrrol_synth_GluAld_NH2Trfase.
IPR005814. Aminotrans_3.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
IPR015422. PyrdxlP-dep_Trfase_major_sub2.
[Graphical view]
PANTHERPTHR11986. PTHR11986. 1 hit.
PfamPF00202. Aminotran_3. 1 hit.
[Graphical view]
PIRSFPIRSF000521. Transaminase_4ab_Lys_Orn. 1 hit.
SUPFAMSSF53383. SSF53383. 1 hit.
TIGRFAMsTIGR00713. hemL. 1 hit.
PROSITEPS00600. AA_TRANSFER_CLASS_3. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGSA_VIBCH
AccessionPrimary (citable) accession number: Q9KU97
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 95 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways