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Protein

Non-canonical purine NTP phosphatase

Gene

VC_0702

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at protein leveli

Functioni

Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA precursor pool, thus preventing their incorporation into DNA and avoiding chromosomal lesions (By similarity).By similarity

Catalytic activityi

A nucleoside triphosphate + H2O = a nucleoside diphosphate + monophosphate.

Cofactori

Mg2+By similarity, Mn2+By similarityNote: Binds 1 divalent metal cation per subunit; can use either Mg2+ or Mn2+.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Nucleotide metabolism

Keywords - Ligandi

Magnesium, Manganese, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVCHO:VC0702-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Non-canonical purine NTP phosphatase (EC:3.6.1.-)
Alternative name(s):
Non-standard purine NTP phosphatase
Nucleoside-triphosphate phosphatase
Short name:
NTPase
Gene namesi
Ordered Locus Names:VC_0702
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000000584 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001563501 – 183Non-canonical purine NTP phosphataseAdd BLAST183

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi243277.VC0702.

Structurei

Secondary structure

1183
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi4 – 6Combined sources3
Beta strandi12 – 16Combined sources5
Helixi20 – 33Combined sources14
Beta strandi40 – 43Combined sources4
Helixi57 – 74Combined sources18
Beta strandi79 – 89Combined sources11
Beta strandi92 – 100Combined sources9
Beta strandi105 – 109Combined sources5
Helixi117 – 123Combined sources7
Helixi129 – 137Combined sources9
Helixi139 – 144Combined sources6
Helixi147 – 152Combined sources6
Turni153 – 155Combined sources3
Helixi159 – 170Combined sources12
Helixi172 – 175Combined sources4
Helixi177 – 179Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZNOX-ray2.00A/B1-183[»]
1ZWYX-ray1.90A/B/C/D1-183[»]
ProteinModelPortaliQ9KU27.
SMRiQ9KU27.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9KU27.

Family & Domainsi

Sequence similaritiesi

Belongs to the YjjX NTPase family.Curated

Phylogenomic databases

eggNOGiENOG4108K16. Bacteria.
COG1986. LUCA.
OMAiADQPMTE.

Family and domain databases

Gene3Di3.90.950.10. 1 hit.
HAMAPiMF_00648. Non_canon_purine_NTPase_YjjX. 1 hit.
InterProiIPR029001. ITPase-like_fam.
IPR002786. Non_canon_purine_NTPase.
IPR026533. NTPase/PRRC1.
[Graphical view]
PfamiPF01931. NTPase_I-T. 1 hit.
[Graphical view]
SUPFAMiSSF52972. SSF52972. 1 hit.
TIGRFAMsiTIGR00258. TIGR00258. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9KU27-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPPIIKRRVM RKIIIASQNP AKVNAVRSAF STVFPDQEWE FIGVSVPSEV
60 70 80 90 100
ADQPMSDEET KQGALNRVRN AKQRHPGAEY YVGLEAGIEE NKTFAWMIVE
110 120 130 140 150
SDQQRGESRS ACLMLPPLVL ERLRQAKELG DVMDEVFGTE NIKQKGGAIG
160 170 180
LLTRHHLTRS TVYHQALILA LIPFINPEHY PSA
Length:183
Mass (Da):20,562
Last modified:October 1, 2000 - v1
Checksum:i425531EDD8017C23
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF93867.1.
PIRiH82290.
RefSeqiNP_230351.1. NC_002505.1.
WP_001883845.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF93867; AAF93867; VC_0702.
GeneIDi2615706.
KEGGivch:VC0702.
PATRICi20080517. VBIVibCho83274_0672.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF93867.1.
PIRiH82290.
RefSeqiNP_230351.1. NC_002505.1.
WP_001883845.1. NC_002505.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ZNOX-ray2.00A/B1-183[»]
1ZWYX-ray1.90A/B/C/D1-183[»]
ProteinModelPortaliQ9KU27.
SMRiQ9KU27.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243277.VC0702.

Protocols and materials databases

DNASUi2615706.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF93867; AAF93867; VC_0702.
GeneIDi2615706.
KEGGivch:VC0702.
PATRICi20080517. VBIVibCho83274_0672.

Phylogenomic databases

eggNOGiENOG4108K16. Bacteria.
COG1986. LUCA.
OMAiADQPMTE.

Enzyme and pathway databases

BioCyciVCHO:VC0702-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9KU27.

Family and domain databases

Gene3Di3.90.950.10. 1 hit.
HAMAPiMF_00648. Non_canon_purine_NTPase_YjjX. 1 hit.
InterProiIPR029001. ITPase-like_fam.
IPR002786. Non_canon_purine_NTPase.
IPR026533. NTPase/PRRC1.
[Graphical view]
PfamiPF01931. NTPase_I-T. 1 hit.
[Graphical view]
SUPFAMiSSF52972. SSF52972. 1 hit.
TIGRFAMsiTIGR00258. TIGR00258. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNCPP_VIBCH
AccessioniPrimary (citable) accession number: Q9KU27
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2003
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 77 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.