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Q9KU08 (PPX_VIBCH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 64. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Exopolyphosphatase

Short name=ExopolyPase
EC=3.6.1.11
Alternative name(s):
Metaphosphatase
Gene names
Name:ppx
Ordered Locus Names:VC_0722
OrganismVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) [Reference proteome] [HAMAP]
Taxonomic identifier243277 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length500 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate By similarity.

Catalytic activity

(Polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate.

Cofactor

Magnesium By similarity.

Sequence similarities

Belongs to the GppA/Ppx family.

Sequence caution

The sequence AAF93887.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 500500Exopolyphosphatase
PRO_0000194306

Experimental info

Sequence conflict4561T → P in AAC32884. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q9KU08 [UniParc].

Last modified April 27, 2001. Version 2.
Checksum: 8AD7BE0C9CB380C1

FASTA50056,445
        10         20         30         40         50         60 
MTTVVSNARE IAAIDLGSNS FHMVVAKVVD QDLQLISRHK QRVRLAAGLD EQKNLDEESI 

        70         80         90        100        110        120 
QRGLECLAMF AERLQGFEPR NVRIAATHTL RQARNANLFI QRALDVLPFP IEIIPGSEEA 

       130        140        150        160        170        180 
RLIYLGVAHT QPQADSMLVV DIGGGSTEMI IGKGFEAELL NSKQMGCVNF TERYFANGKL 

       190        200        210        220        230        240 
SRKNFAQAIV ASEQKLESIA SKYRKKGWQM AFGSSGTIKA IHEVLIGQGH EDGLITFERL 

       250        260        270        280        290        300 
SKLIEKLCEW DSIDDLQLPG LTDDRKPVFA AGVAILSAIF HGLNIKEMHF SDGALREGLL 

       310        320        330        340        350        360 
YEMEDRFKYS DIRLRTTENL AAKHLVDLEH AAKVKGHARE FLAQVANELG LPEGSELCDL 

       370        380        390        400        410        420 
LEWGALLHEV GLSINLQGFH RHSAYILRHN NMAGFNSEQQ LVLSNLARFQ RKSLKLNELD 

       430        440        450        460        470        480 
DFSLFKKKHI IGLIRVLRLA IVVNGQRNDD PLPPLTLSAK DDEWRLECEQ PDWLENNKLL 

       490        500 
HADLQTEQEY WREVGWQLLF 

« Hide

References

« Hide 'large scale' references
[1]"The polyphosphate kinase and exopolyphosphatase genes of Vibrio cholerae."
Ogawa N., Fraley C., Kornberg A.
Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: El Tor Inaba 92A1552.
[2]"DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae."
Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R., Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D., Vamathevan J.J., Bass S. expand/collapse author list , Qin H., Dragoi I., Sellers P., McDonald L.A., Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L., Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M.
Nature 406:477-483(2000) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 39315 / El Tor Inaba N16961.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF083928 Genomic DNA. Translation: AAC32884.1.
AE003852 Genomic DNA. Translation: AAF93887.1. Different initiation.
PIRC82289.
RefSeqNP_230371.1. NC_002505.1.

3D structure databases

ProteinModelPortalQ9KU08.
SMRQ9KU08. Positions 10-500.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243277.VC0722.

Protocols and materials databases

DNASU2615731.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF93887; AAF93887; VC_0722.
GeneID2615731.
KEGGvch:VC0722.
PATRIC20080563. VBIVibCho83274_0690.

Phylogenomic databases

eggNOGCOG0248.
KOK01524.
OMAENNKLLH.
OrthoDBEOG6M6JN6.

Family and domain databases

InterProIPR022371. Exopolyphosphatase.
IPR003695. Ppx_GppA.
[Graphical view]
PfamPF02541. Ppx-GppA. 1 hit.
[Graphical view]
TIGRFAMsTIGR03706. exo_poly_only. 1 hit.
ProtoNetSearch...

Entry information

Entry namePPX_VIBCH
AccessionPrimary (citable) accession number: Q9KU08
Secondary accession number(s): O86074
Entry history
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: May 14, 2014
This is version 64 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families