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Protein

Exopolyphosphatase

Gene

ppx

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate (By similarity).By similarity

Catalytic activityi

(Polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate.

Cofactori

Mg2+By similarity

GO - Molecular functioni

  1. exopolyphosphatase activity Source: TIGR
  2. magnesium ion binding Source: InterPro

GO - Biological processi

  1. phosphorus metabolic process Source: TIGR
  2. polyphosphate catabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Ligandi

Magnesium

Names & Taxonomyi

Protein namesi
Recommended name:
Exopolyphosphatase (EC:3.6.1.11)
Short name:
ExopolyPase
Alternative name(s):
Metaphosphatase
Gene namesi
Name:ppx
Ordered Locus Names:VC_0722
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 500500ExopolyphosphatasePRO_0000194306Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243277.VC0722.

Structurei

3D structure databases

ProteinModelPortaliQ9KU08.
SMRiQ9KU08. Positions 10-500.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GppA/Ppx family.Curated

Phylogenomic databases

eggNOGiCOG0248.
KOiK01524.
OMAiGCVSFTQ.
OrthoDBiEOG6M6JN6.

Family and domain databases

InterProiIPR022371. Exopolyphosphatase.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03706. exo_poly_only. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9KU08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTVVSNARE IAAIDLGSNS FHMVVAKVVD QDLQLISRHK QRVRLAAGLD
60 70 80 90 100
EQKNLDEESI QRGLECLAMF AERLQGFEPR NVRIAATHTL RQARNANLFI
110 120 130 140 150
QRALDVLPFP IEIIPGSEEA RLIYLGVAHT QPQADSMLVV DIGGGSTEMI
160 170 180 190 200
IGKGFEAELL NSKQMGCVNF TERYFANGKL SRKNFAQAIV ASEQKLESIA
210 220 230 240 250
SKYRKKGWQM AFGSSGTIKA IHEVLIGQGH EDGLITFERL SKLIEKLCEW
260 270 280 290 300
DSIDDLQLPG LTDDRKPVFA AGVAILSAIF HGLNIKEMHF SDGALREGLL
310 320 330 340 350
YEMEDRFKYS DIRLRTTENL AAKHLVDLEH AAKVKGHARE FLAQVANELG
360 370 380 390 400
LPEGSELCDL LEWGALLHEV GLSINLQGFH RHSAYILRHN NMAGFNSEQQ
410 420 430 440 450
LVLSNLARFQ RKSLKLNELD DFSLFKKKHI IGLIRVLRLA IVVNGQRNDD
460 470 480 490 500
PLPPLTLSAK DDEWRLECEQ PDWLENNKLL HADLQTEQEY WREVGWQLLF
Length:500
Mass (Da):56,445
Last modified:April 27, 2001 - v2
Checksum:i8AD7BE0C9CB380C1
GO

Sequence cautioni

The sequence AAF93887.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti456 – 4561T → P in AAC32884 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083928 Genomic DNA. Translation: AAC32884.1.
AE003852 Genomic DNA. Translation: AAF93887.1. Different initiation.
PIRiC82289.
RefSeqiNP_230371.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF93887; AAF93887; VC_0722.
GeneIDi2615731.
KEGGivch:VC0722.
PATRICi20080563. VBIVibCho83274_0690.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083928 Genomic DNA. Translation: AAC32884.1.
AE003852 Genomic DNA. Translation: AAF93887.1. Different initiation.
PIRiC82289.
RefSeqiNP_230371.1. NC_002505.1.

3D structure databases

ProteinModelPortaliQ9KU08.
SMRiQ9KU08. Positions 10-500.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243277.VC0722.

Protocols and materials databases

DNASUi2615731.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF93887; AAF93887; VC_0722.
GeneIDi2615731.
KEGGivch:VC0722.
PATRICi20080563. VBIVibCho83274_0690.

Phylogenomic databases

eggNOGiCOG0248.
KOiK01524.
OMAiGCVSFTQ.
OrthoDBiEOG6M6JN6.

Family and domain databases

InterProiIPR022371. Exopolyphosphatase.
IPR003695. Ppx_GppA.
[Graphical view]
PfamiPF02541. Ppx-GppA. 1 hit.
[Graphical view]
TIGRFAMsiTIGR03706. exo_poly_only. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The polyphosphate kinase and exopolyphosphatase genes of Vibrio cholerae."
    Ogawa N., Fraley C., Kornberg A.
    Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: El Tor Inaba 92A1552.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.

Entry informationi

Entry nameiPPX_VIBCH
AccessioniPrimary (citable) accession number: Q9KU08
Secondary accession number(s): O86074
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: January 7, 2015
This is version 67 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.