Reviewed, UniProtKB/Swiss-Prot Q9KU08 (PPX_VIBCH)

Names and origin

Protein names

Recommended name:
    Exopolyphosphatase
      Short name=ExopolyPase
    EC=3.6.1.11
Alternative name(s):
    Metaphosphatase

Gene names

Name:	ppx
Ordered Locus Names:	VC_0722

Organism

Vibrio cholerae [Complete proteome] [HAMAP]

Taxonomic identifier

666 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	500 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate By similarity.
Catalytic activity	(Polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate.
Cofactor	Magnesium By similarity.
Sequence similarities	Belongs to the gppA/ppx family.

Ontologies

Keywords
Ligand	Magnesium
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	exopolyphosphatase activity Inferred from electronic annotation. Source: EC magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 500	500	Exopolyphosphatase		PRO_0000194306
Experimental info
	Sequence conflict	456	1	T → P in AAC32884. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q9KU08-1 [UniParc]. Last modified April 27, 2001. Version 2. Checksum: 8AD7BE0C9CB380C1	FASTA	500	56,445
	10 20 30 40 50 60 MTTVVSNARE IAAIDLGSNS FHMVVAKVVD QDLQLISRHK QRVRLAAGLD EQKNLDEESI 70 80 90 100 110 120 QRGLECLAMF AERLQGFEPR NVRIAATHTL RQARNANLFI QRALDVLPFP IEIIPGSEEA 130 140 150 160 170 180 RLIYLGVAHT QPQADSMLVV DIGGGSTEMI IGKGFEAELL NSKQMGCVNF TERYFANGKL 190 200 210 220 230 240 SRKNFAQAIV ASEQKLESIA SKYRKKGWQM AFGSSGTIKA IHEVLIGQGH EDGLITFERL 250 260 270 280 290 300 SKLIEKLCEW DSIDDLQLPG LTDDRKPVFA AGVAILSAIF HGLNIKEMHF SDGALREGLL 310 320 330 340 350 360 YEMEDRFKYS DIRLRTTENL AAKHLVDLEH AAKVKGHARE FLAQVANELG LPEGSELCDL 370 380 390 400 410 420 LEWGALLHEV GLSINLQGFH RHSAYILRHN NMAGFNSEQQ LVLSNLARFQ RKSLKLNELD 430 440 450 460 470 480 DFSLFKKKHI IGLIRVLRLA IVVNGQRNDD PLPPLTLSAK DDEWRLECEQ PDWLENNKLL 490 500 HADLQTEQEY WREVGWQLLF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The polyphosphate kinase and exopolyphosphatase genes of Vibrio cholerae." Ogawa N., Fraley C., Kornberg A. Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]. Strain: El Tor Inaba 92A1552.
[2]	"DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae." Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R., Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D., Vamathevan J.J., Bass S. , Qin H., Dragoi I., Sellers P., McDonald L.A., Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L., Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M. Nature 406:477-483(2000) [PubMed: 10952301] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 39315 / El Tor Inaba N16961 / Serotype O1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF083928 Genomic DNA. Translation: AAC32884.1. AE003852 Genomic DNA. Translation: AAF93887.1. Different initiation.
PIR	C82289.
RefSeq	NP_230371.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2615731.
GenomeReviews	Gene locus VC_0722 in contig AE003852_GR.
KEGG	vch:VC0722.
TIGR	VC_0722.
Phylogenomic databases
HOGENOM	Q9KU08.
Enzyme and pathway databases
BRENDA	3.6.1.11. 19019.
Family and domain databases
InterPro	IPR003695. Ppx_GppA. [Graphical view]
Pfam	PF02541. Ppx-GppA. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

PPX_VIBCH

Accession

Primary (citable) accession number: Q9KU08
Secondary accession number(s): O86074

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 27, 2001
Last sequence update:	April 27, 2001
Last modified:	January 20, 2009
This is version 41 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)