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Protein

Exopolyphosphatase

Gene

ppx

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Degradation of inorganic polyphosphates (polyP). Releases orthophosphate processively from the ends of the polyP chain.By similarity

Catalytic activityi

(Polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate.By similarity

Cofactori

Mg2+By similarity

GO - Molecular functioni

  • exopolyphosphatase activity Source: TIGR

GO - Biological processi

  • phosphorus metabolic process Source: TIGR
  • polyphosphate catabolic process Source: GO_Central

Keywordsi

Molecular functionHydrolase
LigandMagnesium

Names & Taxonomyi

Protein namesi
Recommended name:
ExopolyphosphataseBy similarity (EC:3.6.1.11By similarity)
Short name:
ExopolyPaseBy similarity
Gene namesi
Name:ppx
Ordered Locus Names:VC_0722
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000000584 Componenti: Chromosome 1

Subcellular locationi

  • Cell membrane By similarity; Peripheral membrane protein By similarity

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001943061 – 500ExopolyphosphataseAdd BLAST500

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi243277.VC0722.

Structurei

3D structure databases

ProteinModelPortaliQ9KU08.
SMRiQ9KU08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GppA/Ppx family.Curated

Phylogenomic databases

eggNOGiENOG4105C9X. Bacteria.
COG0248. LUCA.
KOiK01524.
OMAiRISEGCY.

Family and domain databases

InterProiView protein in InterPro
IPR022371. Exopolyphosphatase.
IPR003695. Ppx_GppA.
IPR030673. PyroPPase_GppA_Ppx.
PfamiView protein in Pfam
PF02541. Ppx-GppA. 1 hit.
PIRSFiPIRSF001267. Pyrophosphatase_GppA_Ppx. 1 hit.
TIGRFAMsiTIGR03706. exo_poly_only. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9KU08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTTVVSNARE IAAIDLGSNS FHMVVAKVVD QDLQLISRHK QRVRLAAGLD
60 70 80 90 100
EQKNLDEESI QRGLECLAMF AERLQGFEPR NVRIAATHTL RQARNANLFI
110 120 130 140 150
QRALDVLPFP IEIIPGSEEA RLIYLGVAHT QPQADSMLVV DIGGGSTEMI
160 170 180 190 200
IGKGFEAELL NSKQMGCVNF TERYFANGKL SRKNFAQAIV ASEQKLESIA
210 220 230 240 250
SKYRKKGWQM AFGSSGTIKA IHEVLIGQGH EDGLITFERL SKLIEKLCEW
260 270 280 290 300
DSIDDLQLPG LTDDRKPVFA AGVAILSAIF HGLNIKEMHF SDGALREGLL
310 320 330 340 350
YEMEDRFKYS DIRLRTTENL AAKHLVDLEH AAKVKGHARE FLAQVANELG
360 370 380 390 400
LPEGSELCDL LEWGALLHEV GLSINLQGFH RHSAYILRHN NMAGFNSEQQ
410 420 430 440 450
LVLSNLARFQ RKSLKLNELD DFSLFKKKHI IGLIRVLRLA IVVNGQRNDD
460 470 480 490 500
PLPPLTLSAK DDEWRLECEQ PDWLENNKLL HADLQTEQEY WREVGWQLLF
Length:500
Mass (Da):56,445
Last modified:April 27, 2001 - v2
Checksum:i8AD7BE0C9CB380C1
GO

Sequence cautioni

The sequence AAF93887 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti456T → P in AAC32884 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF083928 Genomic DNA. Translation: AAC32884.1.
AE003852 Genomic DNA. Translation: AAF93887.1. Different initiation.
PIRiC82289.
RefSeqiNP_230371.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF93887; AAF93887; VC_0722.
GeneIDi2615731.
KEGGivch:VC0722.
PATRICifig|243277.26.peg.690.

Similar proteinsi

Entry informationi

Entry nameiPPX_VIBCH
AccessioniPrimary (citable) accession number: Q9KU08
Secondary accession number(s): O86074
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: October 25, 2017
This is version 87 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families