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Q9KU08

- PPX_VIBCH

UniProt

Q9KU08 - PPX_VIBCH

Protein

Exopolyphosphatase

Gene

ppx

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 65 (01 Oct 2014)
      Sequence version 2 (27 Apr 2001)
      Previous versions | rss
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    Functioni

    Degradation of inorganic polyphosphates. Orthophosphate is released progressively from the ends of polyphosphate By similarity.By similarity

    Catalytic activityi

    (Polyphosphate)(n) + H2O = (polyphosphate)(n-1) + phosphate.

    Cofactori

    Magnesium.By similarity

    GO - Molecular functioni

    1. exopolyphosphatase activity Source: TIGR
    2. magnesium ion binding Source: InterPro

    GO - Biological processi

    1. phosphorus metabolic process Source: TIGR
    2. polyphosphate catabolic process Source: InterPro

    Keywords - Molecular functioni

    Hydrolase

    Keywords - Ligandi

    Magnesium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Exopolyphosphatase (EC:3.6.1.11)
    Short name:
    ExopolyPase
    Alternative name(s):
    Metaphosphatase
    Gene namesi
    Name:ppx
    Ordered Locus Names:VC_0722
    OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
    Taxonomic identifieri243277 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000000584: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 500500ExopolyphosphatasePRO_0000194306Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243277.VC0722.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9KU08.
    SMRiQ9KU08. Positions 10-500.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GppA/Ppx family.Curated

    Phylogenomic databases

    eggNOGiCOG0248.
    KOiK01524.
    OMAiENNKLLH.
    OrthoDBiEOG6M6JN6.

    Family and domain databases

    InterProiIPR022371. Exopolyphosphatase.
    IPR003695. Ppx_GppA.
    [Graphical view]
    PfamiPF02541. Ppx-GppA. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR03706. exo_poly_only. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9KU08-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTTVVSNARE IAAIDLGSNS FHMVVAKVVD QDLQLISRHK QRVRLAAGLD    50
    EQKNLDEESI QRGLECLAMF AERLQGFEPR NVRIAATHTL RQARNANLFI 100
    QRALDVLPFP IEIIPGSEEA RLIYLGVAHT QPQADSMLVV DIGGGSTEMI 150
    IGKGFEAELL NSKQMGCVNF TERYFANGKL SRKNFAQAIV ASEQKLESIA 200
    SKYRKKGWQM AFGSSGTIKA IHEVLIGQGH EDGLITFERL SKLIEKLCEW 250
    DSIDDLQLPG LTDDRKPVFA AGVAILSAIF HGLNIKEMHF SDGALREGLL 300
    YEMEDRFKYS DIRLRTTENL AAKHLVDLEH AAKVKGHARE FLAQVANELG 350
    LPEGSELCDL LEWGALLHEV GLSINLQGFH RHSAYILRHN NMAGFNSEQQ 400
    LVLSNLARFQ RKSLKLNELD DFSLFKKKHI IGLIRVLRLA IVVNGQRNDD 450
    PLPPLTLSAK DDEWRLECEQ PDWLENNKLL HADLQTEQEY WREVGWQLLF 500
    Length:500
    Mass (Da):56,445
    Last modified:April 27, 2001 - v2
    Checksum:i8AD7BE0C9CB380C1
    GO

    Sequence cautioni

    The sequence AAF93887.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti456 – 4561T → P in AAC32884. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF083928 Genomic DNA. Translation: AAC32884.1.
    AE003852 Genomic DNA. Translation: AAF93887.1. Different initiation.
    PIRiC82289.
    RefSeqiNP_230371.1. NC_002505.1.

    Genome annotation databases

    EnsemblBacteriaiAAF93887; AAF93887; VC_0722.
    GeneIDi2615731.
    KEGGivch:VC0722.
    PATRICi20080563. VBIVibCho83274_0690.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF083928 Genomic DNA. Translation: AAC32884.1 .
    AE003852 Genomic DNA. Translation: AAF93887.1 . Different initiation.
    PIRi C82289.
    RefSeqi NP_230371.1. NC_002505.1.

    3D structure databases

    ProteinModelPortali Q9KU08.
    SMRi Q9KU08. Positions 10-500.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243277.VC0722.

    Protocols and materials databases

    DNASUi 2615731.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF93887 ; AAF93887 ; VC_0722 .
    GeneIDi 2615731.
    KEGGi vch:VC0722.
    PATRICi 20080563. VBIVibCho83274_0690.

    Phylogenomic databases

    eggNOGi COG0248.
    KOi K01524.
    OMAi ENNKLLH.
    OrthoDBi EOG6M6JN6.

    Family and domain databases

    InterProi IPR022371. Exopolyphosphatase.
    IPR003695. Ppx_GppA.
    [Graphical view ]
    Pfami PF02541. Ppx-GppA. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR03706. exo_poly_only. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "The polyphosphate kinase and exopolyphosphatase genes of Vibrio cholerae."
      Ogawa N., Fraley C., Kornberg A.
      Submitted (AUG-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
      Strain: El Tor Inaba 92A1552.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39315 / El Tor Inaba N16961.

    Entry informationi

    Entry nameiPPX_VIBCH
    AccessioniPrimary (citable) accession number: Q9KU08
    Secondary accession number(s): O86074
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: April 27, 2001
    Last sequence update: April 27, 2001
    Last modified: October 1, 2014
    This is version 65 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3