Q9KTZ6 (Q9KTZ6_VIBCH) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Malate synthase RuleBase RU000555
EC=2.3.3.9 RuleBase RU000555

Gene names

Ordered Locus Names:

VC_0734

Organism

Vibrio cholerae

Taxonomic identifier

666 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	556 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Acetyl-CoA + H2O + glyoxylate = (S)-malate + CoA. RuleBase RU000555
Pathway	Carbohydrate metabolism; glyoxylate cycle; (S)-malate from isocitrate: step 2/2. RuleBase RU000555
Sequence similarities	Belongs to the malate synthase family. RuleBase RU000555

Ontologies

Keywords
Biological process	Glyoxylate bypass RuleBase RU000555 Tricarboxylic acid cycle RuleBase RU000555
Molecular function	Transferase RuleBase RU000555
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	glyoxylate cycle Inferred from electronic annotation. Source: UniProtKB-KW tricarboxylic acid cycle Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	malate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	189	1	Proton acceptor By similarity PIRSR PIRSR001363-1
	Active site	470	1	Proton donor By similarity PIRSR PIRSR001363-1

Sequences

	Sequence		Length	Mass (Da)
	Q9KTZ6 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: D8EE7BA6701D43B8	FASTA	556	62,858
	10 20 30 40 50 60 MFLVSVSRKE FMSINTAELT QHTTETKITQ GKLAVVGTLS PEHQAIFPVE AQTFLQQLCE 70 80 90 100 110 120 RFAPRVDELL TLREQKQTLI DQGQLPDFLP ETKDIREGSW KILGIPDDLQ DRRVEITGPT 130 140 150 160 170 180 DRKMVINALN ANVKVFMADF EDSMSPAWDK VLDGQINLRD AILGSISYTN PDNGKRYELN 190 200 210 220 230 240 ANPAVLICRV RGLHLKEKHV TYNGLAIPGS LFDFALYFYN NHRALLKKGS GPYFYLPKLQ 250 260 270 280 290 300 AYQEAQWWSD VFHFTEDYFG LDTGTIKATV LIETLPAVFQ MDEILFSLKE HIVGLNCGRW 310 320 330 340 350 360 DYIFSYIKTL KKHPDRVLPD RQVVTMDKPF LNAYSRLLIY TCHKRGAFAM GGMAAFIPAK 370 380 390 400 410 420 DPALNEQVLQ KIRGDKMLEA TNGHDGTWVA HPGLADTAMA VFNEVLGERK NQLNVSRMAD 430 440 450 460 470 480 APITAAELLA PCDGSRSEHG MRHNIRVALQ YIEAWISGNG CVPIYGLMED AATAEISRAS 490 500 510 520 530 540 IWQWIQHGKT LDNGQVVTNE LFRDYLKQEI EVVKSEVGES RFAQGRFTEA AELMERLTTS 550 QELPNFLTIP GYDYLP

References

[1]

"DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae." Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R., Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D., Vamathevan J.J., Bass S. , Qin H., Dragoi I., Sellers P., McDonald L.A., Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L., Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M. Nature 406:477-483(2000) [PubMed: 10952301] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 39315 / El Tor Inaba N16961 / Serotype O1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE003852 Genomic DNA. Translation: AAF93899.1.
PIR	H82287.
RefSeq	NP_230383.1. NC_002505.1.
3D structure databases
ProteinModelPortal	Q9KTZ6.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2615743.
GenomeReviews	Gene locus VC_0734 in contig AE003852_GR.
KEGG	vch:VC0734.
PATRIC	20080585. VBIVibCho83274_0701.
TIGR	VC_0734.
Phylogenomic databases
HOGENOM	HBG649056.
OMA	HIREADW.
PhylomeDB	Q9KTZ6.
ProtClustDB	PRK09255.
Family and domain databases
InterPro	IPR011076. Malate_synth-like. IPR006252. Malate_synthA. IPR001465. Malate_synthase. IPR019830. Malate_synthase_CS. [Graphical view]
KO	K01638.
PANTHER	PTHR21631:SF1. Malate_synthase. 1 hit.
Pfam	PF01274. Malate_synthase. 1 hit. [Graphical view]
PIRSF	PIRSF001363. Malate_synth. 1 hit.
SUPFAM	SSF51645. Malat_synth_like. 1 hit.
TIGRFAMs	TIGR01344. Malate_syn_A. 1 hit.
PROSITE	PS00510. MALATE_SYNTHASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q9KTZ6_VIBCH

Accession

Primary (citable) accession number: Q9KTZ6

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2000
Last sequence update:	October 1, 2000
Last modified:	December 14, 2011
This is version 57 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)