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Q9KTE6 (SYL_VIBCH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Leucine--tRNA ligase

EC=6.1.1.4
Alternative name(s):
Leucyl-tRNA synthetase
Short name=LeuRS
Gene names
Name:leuS
Ordered Locus Names:VC_0956
OrganismVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) [Reference proteome] [HAMAP]
Taxonomic identifier243277 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length858 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu). HAMAP-Rule MF_00049

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00049.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Sequence caution

The sequence AAF94118.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 858858Leucine--tRNA ligase HAMAP-Rule MF_00049
PRO_0000152113

Regions

Motif42 – 5211"HIGH" region HAMAP-Rule MF_00049
Motif618 – 6225"KMSKS" region HAMAP-Rule MF_00049

Sites

Binding site6211ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9KTE6 [UniParc].

Last modified June 1, 2001. Version 2.
Checksum: A4D59A2E1C9F1292

FASTA85896,621
        10         20         30         40         50         60 
MQEQYNPQDI EHKVQQHWDN NKTFVVSEDP NKEKFYCLSM FPYPSGRLHM GHVRNYTIGD 

        70         80         90        100        110        120 
VVSRFQRLQG KNVLQPIGWD AFGLPAENAA VKNNTAPAPW TYENIEYMKN QLKLLGFGYD 

       130        140        150        160        170        180 
WNREFATCRP EYYRWEQEFF TKLFAKGLVY KKTSSVNWCP NDQTVLANEQ VEDGCCWRCD 

       190        200        210        220        230        240 
TPVEQKEIPQ WFIKITAYAQ ELLDDLDNLD GWPEMVKTMQ RNWIGRSEGV ELKFAVKGEN 

       250        260        270        280        290        300 
TDLEVYTTRP DTLMGVTYVG IAAGHPLATK AAANNPALAA FIDECKNTKV AEAEIATMEK 

       310        320        330        340        350        360 
KGMATGLTAI HPLNGREVPI YIANFVLMDY GTGAVMAVPA HDQRDFEFAT KYGLDIIPVI 

       370        380        390        400        410        420 
KPADGSELDV SEAAYTEKGV LFASGEFDGL DFQAAFNAIA AKLEAEGKGK KTVNFRLRDW 

       430        440        450        460        470        480 
GVSRQRYWGA PIPMVTTEDG QVHPVPADQL PVILPEDVVM DGVTSPIKAD KEWAKTTFNG 

       490        500        510        520        530        540 
EPALRETDTF DTFMESSWYY ARYCSPQADD ILDPEKANYW LPVDQYIGGI EHACMHLLYS 

       550        560        570        580        590        600 
RFFHKLLRDA GYVKSDEPFK KLLCQGMVLA DAFYYTNDKG GKEWVSPTEV KVERDGKGRI 

       610        620        630        640        650        660 
VSAVDATGRQ VEHSGMIKMS KSKNNGIDPQ EMVDKYGADT VRLFMMFASP ADMTLEWQES 

       670        680        690        700        710        720 
GVEGANRFLR RVWKLVREHT ELGQAPALDA SALNADQKAL RRDVHKTIAK VTDDVARRQT 

       730        740        750        760        770        780 
FNTAIAAIME LMNKLTKAPM TEAQDRAILD EALKAITLML YPITPHICFE MWVALGQSNI 

       790        800        810        820        830        840 
DTASWPTYDE AALVEDEKLI VLQVNGKLRG KLTVAADATQ QQVEALGMQD ENVQKFIDGL 

       850 
TVRKVIYVPG KLLNIVAN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE003852 Genomic DNA. Translation: AAF94118.1. Different initiation.
PIRG82260.
RefSeqNP_230603.2. NC_002505.1.

3D structure databases

ProteinModelPortalQ9KTE6.
SMRQ9KTE6. Positions 228-413.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243277.VC0956.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF94118; AAF94118; VC_0956.
GeneID2614209.
KEGGvch:VC0956.
PATRIC20081012. VBIVibCho83274_0910.

Phylogenomic databases

eggNOGCOG0495.
KOK01869.
OMAGIEHACM.
OrthoDBEOG63Z74X.
ProtClustDBPRK00390.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPMF_00049_B. Leu_tRNA_synth_B.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase_bac/mito.
IPR025709. Leu_tRNA-synth_edit.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR013155. V/L/I-tRNA-synth_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSPR00985. TRNASYNTHLEU.
SUPFAMSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsTIGR00396. leuS_bact. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYL_VIBCH
AccessionPrimary (citable) accession number: Q9KTE6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: June 1, 2001
Last modified: April 16, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries