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Protein

Phosphocarrier protein HPr

Gene

ptsH

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei15Pros-phosphohistidine intermediatePROSITE-ProRule annotation1

GO - Molecular functioni

  • protein-N(PI)-phosphohistidine-sugar phosphotransferase activity Source: TIGR

GO - Biological processi

  • phosphoenolpyruvate-dependent sugar phosphotransferase system Source: TIGR

Keywordsi

Biological processPhosphotransferase system, Sugar transport, Transport

Enzyme and pathway databases

BioCyciVCHO:VC0966-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphocarrier protein HPr
Alternative name(s):
Histidine-containing protein
Gene namesi
Name:ptsH
Ordered Locus Names:VC_0966
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000000584 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001078861 – 85Phosphocarrier protein HPrAdd BLAST85

Interactioni

Protein-protein interaction databases

STRINGi243277.VC0966

Structurei

3D structure databases

ProteinModelPortaliQ9KTD6
SMRiQ9KTD6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 85HPrPROSITE-ProRule annotationAdd BLAST85

Sequence similaritiesi

Belongs to the HPr family.Curated

Phylogenomic databases

eggNOGiENOG4105KZ7 Bacteria
COG1925 LUCA
KOiK02784
OMAiRPGNEFV

Family and domain databases

CDDicd00367 PTS-HPr_like, 1 hit
Gene3Di3.30.1340.10, 1 hit
InterProiView protein in InterPro
IPR000032 HPr-like
IPR035895 HPr-like_sf
IPR001020 PTS_HPr_His_P_site
IPR002114 PTS_HPr_Ser_P_site
PfamiView protein in Pfam
PF00381 PTS-HPr, 1 hit
PRINTSiPR00107 PHOSPHOCPHPR
SUPFAMiSSF55594 SSF55594, 1 hit
TIGRFAMsiTIGR01003 PTS_HPr_family, 1 hit
PROSITEiView protein in PROSITE
PS51350 PTS_HPR_DOM, 1 hit
PS00369 PTS_HPR_HIS, 1 hit
PS00589 PTS_HPR_SER, 1 hit

Sequencei

Sequence statusi: Complete.

Q9KTD6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYEKQVEITA ENGLHTRPAA QFVKEAKAFD ADITVTSNGK SASAKSLFKL
60 70 80
QTLGLVKGTV VTISAEGPQA KEAVEHLVAL MDQLH
Length:85
Mass (Da):9,109
Last modified:October 1, 2000 - v1
Checksum:iA4A48540C69A3252
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA Translation: AAF94128.1
PIRiA82258
RefSeqiNP_230613.1, NC_002505.1
WP_000273061.1, NC_002505.1

Genome annotation databases

EnsemblBacteriaiAAF94128; AAF94128; VC_0966
GeneIDi2614219
KEGGivch:VC0966
PATRICifig|243277.26.peg.920

Similar proteinsi

Entry informationi

Entry nameiPTHP_VIBCH
AccessioniPrimary (citable) accession number: Q9KTD6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 107 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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