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Q9KT93

- LGUL_VIBCH

UniProt

Q9KT93 - LGUL_VIBCH

Protein

Probable lactoylglutathione lyase

Gene

gloA

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 86 (01 Oct 2014)
      Sequence version 2 (20 Mar 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione.By similarity

    Catalytic activityi

    (R)-S-lactoylglutathione = glutathione + methylglyoxal.

    Cofactori

    Binds 1 nickel ion per subunit.By similarity

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi8 – 81Nickel; via tele nitrogenBy similarity
    Binding sitei12 – 121SubstrateBy similarity
    Metal bindingi59 – 591NickelBy similarity
    Binding sitei63 – 631SubstrateBy similarity
    Metal bindingi77 – 771Nickel; via tele nitrogenBy similarity
    Binding sitei77 – 771SubstrateBy similarity
    Active sitei125 – 1251Proton donor/acceptorBy similarity
    Metal bindingi125 – 1251NickelBy similarity

    GO - Molecular functioni

    1. lactoylglutathione lyase activity Source: TIGR
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. glutathione metabolic process Source: TIGR

    Keywords - Molecular functioni

    Lyase

    Keywords - Ligandi

    Metal-binding, Nickel

    Enzyme and pathway databases

    UniPathwayiUPA00619; UER00675.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable lactoylglutathione lyase (EC:4.4.1.5)
    Alternative name(s):
    Aldoketomutase
    Glyoxalase I
    Short name:
    Glx I
    Ketone-aldehyde mutase
    Methylglyoxalase
    S-D-lactoylglutathione methylglyoxal lyase
    Gene namesi
    Name:gloA
    Ordered Locus Names:VC_1010
    OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
    Taxonomic identifieri243277 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000000584: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 138138Probable lactoylglutathione lyasePRO_0000168097Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243277.VC1010.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9KT93.
    SMRiQ9KT93. Positions 5-128.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glyoxalase I family.Curated

    Phylogenomic databases

    eggNOGiCOG0346.
    KOiK01759.
    OMAiIGEEDIY.
    OrthoDBiEOG6DVJXX.

    Family and domain databases

    Gene3Di3.10.180.10. 1 hit.
    InterProiIPR029068. Glyas_Bleomycin-R_OHBP_Dase.
    IPR004360. Glyas_Fos-R_dOase_dom.
    IPR004361. Glyoxalase_1.
    IPR018146. Glyoxalase_1_CS.
    [Graphical view]
    PfamiPF00903. Glyoxalase. 1 hit.
    [Graphical view]
    SUPFAMiSSF54593. SSF54593. 1 hit.
    TIGRFAMsiTIGR00068. glyox_I. 1 hit.
    PROSITEiPS00934. GLYOXALASE_I_1. 1 hit.
    PS00935. GLYOXALASE_I_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9KT93-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSNHRILHTM LRVGDLDKSI EFYTQVMGMS LLRKNENTEY KYTLAFLGYG    50
    DESQGAVIEL TYNWGVADYE KGNAYGHIAI GVDDIYATCD TIKAAGGIVT 100
    REPGPVKGGT THIAFVKDPD GYMIELIQNK QAHAGLEG 138
    Length:138
    Mass (Da):15,176
    Last modified:March 20, 2007 - v2
    Checksum:i21427CF9AA2E51BD
    GO

    Sequence cautioni

    The sequence AAF94171.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE003852 Genomic DNA. Translation: AAF94171.1. Different initiation.
    PIRiH82251.
    RefSeqiNP_230656.2. NC_002505.1.

    Genome annotation databases

    EnsemblBacteriaiAAF94171; AAF94171; VC_1010.
    GeneIDi2614263.
    KEGGivch:VC1010.
    PATRICi20081120. VBIVibCho83274_0964.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE003852 Genomic DNA. Translation: AAF94171.1 . Different initiation.
    PIRi H82251.
    RefSeqi NP_230656.2. NC_002505.1.

    3D structure databases

    ProteinModelPortali Q9KT93.
    SMRi Q9KT93. Positions 5-128.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243277.VC1010.

    Protocols and materials databases

    DNASUi 2614263.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF94171 ; AAF94171 ; VC_1010 .
    GeneIDi 2614263.
    KEGGi vch:VC1010.
    PATRICi 20081120. VBIVibCho83274_0964.

    Phylogenomic databases

    eggNOGi COG0346.
    KOi K01759.
    OMAi IGEEDIY.
    OrthoDBi EOG6DVJXX.

    Enzyme and pathway databases

    UniPathwayi UPA00619 ; UER00675 .

    Family and domain databases

    Gene3Di 3.10.180.10. 1 hit.
    InterProi IPR029068. Glyas_Bleomycin-R_OHBP_Dase.
    IPR004360. Glyas_Fos-R_dOase_dom.
    IPR004361. Glyoxalase_1.
    IPR018146. Glyoxalase_1_CS.
    [Graphical view ]
    Pfami PF00903. Glyoxalase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54593. SSF54593. 1 hit.
    TIGRFAMsi TIGR00068. glyox_I. 1 hit.
    PROSITEi PS00934. GLYOXALASE_I_1. 1 hit.
    PS00935. GLYOXALASE_I_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39315 / El Tor Inaba N16961.

    Entry informationi

    Entry nameiLGUL_VIBCH
    AccessioniPrimary (citable) accession number: Q9KT93
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: March 20, 2007
    Last modified: October 1, 2014
    This is version 86 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3