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Protein

Phosphate acetyltransferase

Gene

pta

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in acetate metabolism.By similarity

Catalytic activityi

Acetyl-CoA + phosphate = CoA + acetyl phosphate.

Pathwayi

GO - Molecular functioni

  1. phosphate acetyltransferase activity Source: TIGR

GO - Biological processi

  1. acetyl-CoA biosynthetic process Source: UniProtKB-UniPathway
  2. fermentation Source: TIGR
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciVCHO:VC1097-MONOMER.
UniPathwayiUPA00340; UER00459.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate acetyltransferase (EC:2.3.1.8)
Alternative name(s):
Phosphotransacetylase
Gene namesi
Name:pta
Ordered Locus Names:VC_1097
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584: Chromosome 1

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 714714Phosphate acetyltransferasePRO_0000405554Add
BLAST

Proteomic databases

PRIDEiQ9KT08.

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

STRINGi243277.VC1097.

Structurei

3D structure databases

ProteinModelPortaliQ9KT08.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni390 – 714325Phosphate acetyltransferaseAdd
BLAST

Domaini

The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site (By similarity).By similarity

Sequence similaritiesi

In the N-terminal section; belongs to the CobB/CobQ family.Curated
In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.Curated

Phylogenomic databases

eggNOGiCOG0280.
KOiK13788.
OMAiKPIAQPH.
OrthoDBiEOG6BKJ5W.

Family and domain databases

Gene3Di3.40.1390.20. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR010766. DRTGG.
IPR016475. P-Actrans_bac.
IPR027417. P-loop_NTPase.
IPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
IPR028979. Ser_kin/Pase_Hpr_N_like.
[Graphical view]
PfamiPF07085. DRTGG. 1 hit.
PF01515. PTA_PTB. 1 hit.
[Graphical view]
PIRSFiPIRSF006107. PhpActrans_proteobac. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF75138. SSF75138. 1 hit.
TIGRFAMsiTIGR00651. pta. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9KT08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRTIMLIPI SAGVGLTSVS MGLLRAMERK GVSVSFYKPI AQPRTGDDQP
60 70 80 90 100
DLTSTVMSRN SDIKIGQPMS MSAAETLIGS EKMDVLLETV VERYNQINKD
110 120 130 140 150
AEVTLIEGLV PTRKHPFANQ VNAEIANTLG AEIVFVATPG TDNPTQLKER
160 170 180 190 200
IEVACSNFGG TKNKSISGVI INKLNAPVDE AGRTRPDLSE IFDDADHAKQ
210 220 230 240 250
ANLEVMQIFN TSPIRVLGCV PWSIDLIATR AIDMAKHLKA EIINQGDINT
260 270 280 290 300
RRIKSITFCA RSIPNMIEHF KPGSLLVTSA DRPDVIVAAA LAAMNGVEIG
310 320 330 340 350
AVLLTGGYDI PRELVSLCKP AFDTGLPIFK AQGNTWQTSL NLQSFSLEVP
360 370 380 390 400
ADDKERIEFI SEHVASHIDG PWVDSLTEGA QASRRLSPPA FRYQLTELAR
410 420 430 440 450
SANKRIVLPE GDEPRTVKAA AICAERGIAQ CVLLGNPEEI KRVAAQQGVE
460 470 480 490 500
LGSGIEIIDP KVAQEKYVAR LVELRKSKGM TEVVAREQLE DTVVLGTMML
510 520 530 540 550
ERNEVDGLVS GAVHTTANTI RPPLQIIKTA PNASLVSSIF FMLLPDQVLV
560 570 580 590 600
YGDCAINPDP NAEQLAEIAI QSADSAAAFG IEPRVAMISY STGTSGQGAD
610 620 630 640 650
VDKVREATRI AKEKRPDLVI DGPLQYDAAI MENVAASKAP NSPVAGKATV
660 670 680 690 700
FVFPDLNTGN TTYKAVQRSA DLVSIGPMLQ GMRKPVNDLS RGALVDDIVY
710
TIALTAIQAG QEQK
Length:714
Mass (Da):76,892
Last modified:October 1, 2000 - v1
Checksum:i18B90F0A6D87AC80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF94256.1.
PIRiH82242.
RefSeqiNP_230742.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF94256; AAF94256; VC_1097.
GeneIDi2614367.
KEGGivch:VC1097.
PATRICi20081288. VBIVibCho83274_1047.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF94256.1.
PIRiH82242.
RefSeqiNP_230742.1. NC_002505.1.

3D structure databases

ProteinModelPortaliQ9KT08.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243277.VC1097.

Proteomic databases

PRIDEiQ9KT08.

Protocols and materials databases

DNASUi2614367.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF94256; AAF94256; VC_1097.
GeneIDi2614367.
KEGGivch:VC1097.
PATRICi20081288. VBIVibCho83274_1047.

Phylogenomic databases

eggNOGiCOG0280.
KOiK13788.
OMAiKPIAQPH.
OrthoDBiEOG6BKJ5W.

Enzyme and pathway databases

UniPathwayiUPA00340; UER00459.
BioCyciVCHO:VC1097-MONOMER.

Family and domain databases

Gene3Di3.40.1390.20. 1 hit.
3.40.50.300. 1 hit.
InterProiIPR010766. DRTGG.
IPR016475. P-Actrans_bac.
IPR027417. P-loop_NTPase.
IPR004614. P_AcTrfase.
IPR002505. PTA_PTB.
IPR028979. Ser_kin/Pase_Hpr_N_like.
[Graphical view]
PfamiPF07085. DRTGG. 1 hit.
PF01515. PTA_PTB. 1 hit.
[Graphical view]
PIRSFiPIRSF006107. PhpActrans_proteobac. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
SSF75138. SSF75138. 1 hit.
TIGRFAMsiTIGR00651. pta. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.

Entry informationi

Entry nameiPTA_VIBCH
AccessioniPrimary (citable) accession number: Q9KT08
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: October 1, 2000
Last modified: January 7, 2015
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.