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Protein

Phosphate acetyltransferase

Gene

pta

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Involved in acetate metabolism.By similarity

Catalytic activityi

Acetyl-CoA + phosphate = CoA + acetyl phosphate.

Pathwayi: acetyl-CoA biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes acetyl-CoA from acetate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Acetate kinase 2 (ackA2), Acetate kinase 1 (ackA1)
  2. Phosphate acetyltransferase (pta)
This subpathway is part of the pathway acetyl-CoA biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA from acetate, the pathway acetyl-CoA biosynthesis and in Metabolic intermediate biosynthesis.

GO - Molecular functioni

  • phosphate acetyltransferase activity Source: TIGR

GO - Biological processi

  • acetyl-CoA biosynthetic process Source: UniProtKB-UniPathway
  • fermentation Source: TIGR

Keywordsi

Molecular functionAcyltransferase, Transferase

Enzyme and pathway databases

BioCyciVCHO:VC1097-MONOMER
UniPathwayiUPA00340; UER00459

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphate acetyltransferase (EC:2.3.1.8)
Alternative name(s):
Phosphotransacetylase
Gene namesi
Name:pta
Ordered Locus Names:VC_1097
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000000584 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004055541 – 714Phosphate acetyltransferaseAdd BLAST714

Proteomic databases

PRIDEiQ9KT08

Interactioni

Subunit structurei

Homohexamer.By similarity

Protein-protein interaction databases

STRINGi243277.VC1097

Structurei

3D structure databases

ProteinModelPortaliQ9KT08
SMRiQ9KT08
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni390 – 714Phosphate acetyltransferaseAdd BLAST325

Domaini

The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site (By similarity).By similarity

Sequence similaritiesi

In the N-terminal section; belongs to the CobB/CobQ family.Curated
In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.Curated

Phylogenomic databases

eggNOGiENOG4108DNC Bacteria
COG0280 LUCA
COG0857 LUCA
KOiK13788
OMAiTPLMFEY

Family and domain databases

Gene3Di3.40.1390.20, 1 hit
InterProiView protein in InterPro
IPR010766 DRTGG
IPR016475 P-Actrans_bac
IPR027417 P-loop_NTPase
IPR004614 P_AcTrfase
IPR002505 PTA_PTB
IPR028979 Ser_kin/Pase_Hpr-like_N_sf
PfamiView protein in Pfam
PF07085 DRTGG, 1 hit
PF01515 PTA_PTB, 1 hit
PIRSFiPIRSF006107 PhpActrans_proteobac, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
SSF75138 SSF75138, 1 hit
TIGRFAMsiTIGR00651 pta, 1 hit

Sequencei

Sequence statusi: Complete.

Q9KT08-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRTIMLIPI SAGVGLTSVS MGLLRAMERK GVSVSFYKPI AQPRTGDDQP
60 70 80 90 100
DLTSTVMSRN SDIKIGQPMS MSAAETLIGS EKMDVLLETV VERYNQINKD
110 120 130 140 150
AEVTLIEGLV PTRKHPFANQ VNAEIANTLG AEIVFVATPG TDNPTQLKER
160 170 180 190 200
IEVACSNFGG TKNKSISGVI INKLNAPVDE AGRTRPDLSE IFDDADHAKQ
210 220 230 240 250
ANLEVMQIFN TSPIRVLGCV PWSIDLIATR AIDMAKHLKA EIINQGDINT
260 270 280 290 300
RRIKSITFCA RSIPNMIEHF KPGSLLVTSA DRPDVIVAAA LAAMNGVEIG
310 320 330 340 350
AVLLTGGYDI PRELVSLCKP AFDTGLPIFK AQGNTWQTSL NLQSFSLEVP
360 370 380 390 400
ADDKERIEFI SEHVASHIDG PWVDSLTEGA QASRRLSPPA FRYQLTELAR
410 420 430 440 450
SANKRIVLPE GDEPRTVKAA AICAERGIAQ CVLLGNPEEI KRVAAQQGVE
460 470 480 490 500
LGSGIEIIDP KVAQEKYVAR LVELRKSKGM TEVVAREQLE DTVVLGTMML
510 520 530 540 550
ERNEVDGLVS GAVHTTANTI RPPLQIIKTA PNASLVSSIF FMLLPDQVLV
560 570 580 590 600
YGDCAINPDP NAEQLAEIAI QSADSAAAFG IEPRVAMISY STGTSGQGAD
610 620 630 640 650
VDKVREATRI AKEKRPDLVI DGPLQYDAAI MENVAASKAP NSPVAGKATV
660 670 680 690 700
FVFPDLNTGN TTYKAVQRSA DLVSIGPMLQ GMRKPVNDLS RGALVDDIVY
710
TIALTAIQAG QEQK
Length:714
Mass (Da):76,892
Last modified:October 1, 2000 - v1
Checksum:i18B90F0A6D87AC80
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA Translation: AAF94256.1
PIRiH82242
RefSeqiNP_230742.1, NC_002505.1
WP_000091710.1, NC_002505.1

Genome annotation databases

EnsemblBacteriaiAAF94256; AAF94256; VC_1097
GeneIDi2614367
KEGGivch:VC1097
PATRICifig|243277.26.peg.1047

Similar proteinsi

Entry informationi

Entry nameiPTA_VIBCH
AccessioniPrimary (citable) accession number: Q9KT08
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: October 1, 2000
Last modified: March 28, 2018
This is version 79 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

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