Q9KT07 (ACKA1_VIBCH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Acetate kinase 1
EC=2.7.2.1

Alternative name(s):
Acetokinase 1

Gene names

Name:	ackA1
Ordered Locus Names:	VC_1098

Organism

Vibrio cholerae

Taxonomic identifier

666 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	398 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + acetate = ADP + acetyl phosphate. HAMAP MF_00020 ATP + propanoate = ADP + propanoyl phosphate. HAMAP MF_00020
Pathway	Metabolic intermediate biosynthesis; acetyl-CoA biosynthesis; acetyl-CoA from acetate: step 1/2. HAMAP MF_00020
Subcellular location	Cytoplasm By similarity HAMAP MF_00020.
Sequence similarities	Belongs to the acetokinase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	organic acid metabolic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW acetate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 398	398	Acetate kinase 1 HAMAP MF_00020		PRO_0000107635

Sequences

	Sequence		Length	Mass (Da)
	Q9KT07 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 42D6CE78F8B410B6	FASTA	398	42,843
	10 20 30 40 50 60 MSKLVLVLNC GSSSLKFAVV DAQSGEQHLS GLAECLHLPE ARIKWKLDGK HEAQLGEGAA 70 80 90 100 110 120 HDEALSFIVE TILASKPELA AQLKAIGHRV VHGGEQFTQS ALIDDAVLKG IEDCAALAPL 130 140 150 160 170 180 HNPAHIIGIK AAQKAFPELK NVAVFDTAFH QTMPEEAYLY ALPYNLYKEH GIRRYGMHGT 190 200 210 220 230 240 SHLFIAREAA ERLGKPANEL NIINCHLGNG ASVCAIKNGQ SVDTSMGLTP LEGLVMGTRC 250 260 270 280 290 300 GDIDPAIIFH LHDTLGYSVE KINTMLTKES GLLGLTEVTS DCRFVEDNYG QKEEATRAMD 310 320 330 340 350 360 VFCHRLAKYV AGYTASLDGR LDAITFTGGI GENSAPIREM VLNRLAIFGI TVDSAANLKA 370 380 390 RFGGEGVITT ADSRIPAMVI ATNEELVIAE DTARLTNI

References

[1]

"DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae." Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R., Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D., Vamathevan J.J., Bass S. , Qin H., Dragoi I., Sellers P., McDonald L.A., Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L., Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M. Nature 406:477-483(2000) [PubMed: 10952301] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 39315 / El Tor Inaba N16961 / Serotype O1.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE003852 Genomic DNA. Translation: AAF94257.1.
PIR	A82243.
RefSeq	NP_230743.1. NC_002505.1.
3D structure databases
ProteinModelPortal	Q9KT07.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2614368.
GenomeReviews	Gene locus VC_1098 in contig AE003852_GR.
KEGG	vch:VC1098.
PATRIC	20081290. VBIVibCho83274_1048.
TIGR	VC_1098.
Phylogenomic databases
HOGENOM	HBG285863.
OMA	YLPEARI.
PhylomeDB	Q9KT07.
ProtClustDB	PRK00180.
Family and domain databases
HAMAP	MF_00020. Acetate_kinase. [Tree]
InterPro	IPR004372. Ac/Proprionate_kinase. IPR000890. Aliphatic_acid_kin_short-chain. IPR023865. Aliphatic_acid_kinase_CS. [Graphical view]
KO	K00925.
PANTHER	PTHR21060. Acetate_kin. 1 hit.
Pfam	PF00871. Acetate_kinase. 1 hit. [Graphical view]
PIRSF	PIRSF000722. Acetate_prop_kin. 1 hit.
PRINTS	PR00471. ACETATEKNASE.
TIGRFAMs	TIGR00016. AckA. 1 hit.
PROSITE	PS01075. ACETATE_KINASE_1. 1 hit. PS01076. ACETATE_KINASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ACKA1_VIBCH

Accession

Primary (citable) accession number: Q9KT07

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 23, 2003
Last sequence update:	October 1, 2000
Last modified:	January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program