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Q9KSW9 (HIS4_VIBCH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase
EC=5.3.1.16
Alternative name(s):
Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase
Gene names
Name:hisA
Ordered Locus Names:VC_1137
OrganismVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) [Reference proteome] [HAMAP]
Taxonomic identifier243277 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio ›

Protein attributes

Sequence length245 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

1-(5-phospho-beta-D-ribosyl)-5-((5-phospho-beta-D-ribosylamino)methylideneamino)imidazole-4-carboxamide = 5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_01014

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 4/9. HAMAP-Rule MF_01014

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01014.

Sequence similarities

Belongs to the HisA/HisF family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2452451-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase HAMAP-Rule MF_01014
PRO_0000142071

Sites

Active site71Proton acceptor By similarity
Active site1291Proton donor By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9KSW9 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 5A913A5ABEC55D3D

FASTA24526,339
        10         20         30         40         50         60 
MIIPALDLIE GQVVRLYQGD YGQVTEYKVD PAEQFNLYHQ AGAGWLHLVD LTGAKNTAAR 

        70         80         90        100        110        120 
QLNLIARLLA STPANIQIGG GVRSEQDVVD LLEAGAQRVV VGSTAVKQPQ LVKSWIEKYG 

       130        140        150        160        170        180 
AEKIVLALDI NIDEQGTRKV AISGWQEDSG VTIEALIDDY LTVGLQHVLC TDISRDGTLA 

       190        200        210        220        230        240 
GSNVELYRDL CRQYPQVQFQ SSGGIGSLAD IEALKGTGVA GVIVGRALLD GKFTAQEAFA 


CWQNG

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE003852 Genomic DNA. Translation: AAF94296.1.
PIRD82238.
RefSeqNP_230782.1. NC_002505.1.

3D structure databases

ProteinModelPortalQ9KSW9.
ModBaseSearch...

Protein-protein interaction databases

STRING243277.VC1137.

Protocols and materials databases

DNASU2614407.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF94296; AAF94296; VC_1137.
GeneID2614407.
KEGGvch:VC1137.
PATRIC20081366. VBIVibCho83274_1086.

Phylogenomic databases

eggNOGCOG0106.
KOK01814.
OMADGHCVRL.
ProtClustDBPRK00748.

Enzyme and pathway databases

UniPathwayUPA00031; UER00009.

Family and domain databases

Gene3D3.20.20.70. 1 hit.
HAMAPMF_01014. HisA.
InterProIPR013785. Aldolase_TIM.
IPR006062. His_biosynth.
IPR006063. HisA.
IPR023016. Isoase_HisA.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamPF00977. His_biosynth. 1 hit.
[Graphical view]
SUPFAMSSF51366. RibP_bind_barrel. 1 hit.
TIGRFAMsTIGR00007. TIGR00007. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHIS4_VIBCH
AccessionPrimary (citable) accession number: Q9KSW9
Entry history
Integrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: October 1, 2000
Last modified: May 29, 2013
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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