Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9KST5

- TRPC_VIBCH

UniProt

Q9KST5 - TRPC_VIBCH

Protein

Tryptophan biosynthesis protein TrpCF

Gene

trpCF

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain By similarity.By similarity

    Catalytic activityi

    N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.
    1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.

    Pathwayi

    GO - Molecular functioni

    1. indole-3-glycerol-phosphate synthase activity Source: TIGR
    2. phosphoribosylanthranilate isomerase activity Source: TIGR

    GO - Biological processi

    1. tryptophan biosynthetic process Source: TIGR

    Keywords - Molecular functioni

    Decarboxylase, Isomerase, Lyase

    Keywords - Biological processi

    Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

    Enzyme and pathway databases

    BioCyciVCHO:VC1171-MONOMER.
    UniPathwayiUPA00035; UER00042.
    UPA00035; UER00043.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan biosynthesis protein TrpCF
    Including the following 2 domains:
    Indole-3-glycerol phosphate synthase (EC:4.1.1.48)
    Short name:
    IGPS
    N-(5'-phospho-ribosyl)anthranilate isomerase (EC:5.3.1.24)
    Short name:
    PRAI
    Gene namesi
    Name:trpCF
    Ordered Locus Names:VC_1171
    OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
    Taxonomic identifieri243277 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000000584: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 469469Tryptophan biosynthesis protein TrpCFPRO_0000154285Add
    BLAST

    Interactioni

    Subunit structurei

    Monomer.

    Protein-protein interaction databases

    STRINGi243277.VC1171.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9KST5.
    SMRiQ9KST5. Positions 16-469.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 271271Indole-3-glycerol phosphate synthaseAdd
    BLAST
    Regioni272 – 469198N-(5'-phosphoribosyl)anthranilate isomeraseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the TrpC family.Curated
    In the C-terminal section; belongs to the TrpF family.Curated

    Phylogenomic databases

    eggNOGiCOG0134.
    KOiK13498.
    OMAiEKYFQGD.
    OrthoDBiEOG6WT8JX.

    Family and domain databases

    Gene3Di3.20.20.70. 2 hits.
    HAMAPiMF_00134_B. IGPS_B.
    MF_00135. PRAI.
    InterProiIPR013785. Aldolase_TIM.
    IPR013798. Indole-3-glycerol_P_synth.
    IPR001468. Indole-3-GlycerolPSynthase_CS.
    IPR001240. PRAI_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view]
    PfamiPF00218. IGPS. 1 hit.
    PF00697. PRAI. 1 hit.
    [Graphical view]
    SUPFAMiSSF51366. SSF51366. 2 hits.
    PROSITEiPS00614. IGPS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9KST5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSEQLSEHIS VQTAQMAQVL VKIVNDKYQW IEERKAKQPL ASFHPLLTRS    50
    ERDFYQALSG DNTVFILECK KASPSKGLIR EEFDLDYIAS VYGEYASAIS 100
    VLTDEKYFQG RFEFLPQVRA QVAQPVLCKD FMVDPYQVYL ARHYQADAIL 150
    LMLSVLNDDQ YRELAAVAHD LGMGVLTEVS NEQELKRAVD LQAKVIGINN 200
    RNLRDLTTDL NRTKQLAPLI PQGTIIISES GIYTHQQVRD LAEFANGFLI 250
    GSSLMAQSNL ELAVRKIVLG EHKVCGLTHP DDAVKAYQAG SVFGGLIFVE 300
    KSKRFVDVEQ ARLTMSGAPL QYVGVFQNHP AAQVADIATK LGLFAVQLHG 350
    EEDSAYVSEL RASLPESIEI WKAYGVSDAL PELLPEHIDR HLLDAKVGEQ 400
    SGGTGRSFDW RLLPKHSDLM LAGGLSAENV AQAAQLGCRG LDFNSGVESA 450
    PGKKDANQLQ QVFQQLRNY 469
    Length:469
    Mass (Da):52,038
    Last modified:October 1, 2000 - v1
    Checksum:iAAFF776A0D8EC66E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE003852 Genomic DNA. Translation: AAF94330.1.
    PIRiF82232.
    RefSeqiNP_230816.1. NC_002505.1.

    Genome annotation databases

    EnsemblBacteriaiAAF94330; AAF94330; VC_1171.
    GeneIDi2614604.
    KEGGivch:VC1171.
    PATRICi20081434. VBIVibCho83274_1120.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE003852 Genomic DNA. Translation: AAF94330.1 .
    PIRi F82232.
    RefSeqi NP_230816.1. NC_002505.1.

    3D structure databases

    ProteinModelPortali Q9KST5.
    SMRi Q9KST5. Positions 16-469.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243277.VC1171.

    Protocols and materials databases

    DNASUi 2614604.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF94330 ; AAF94330 ; VC_1171 .
    GeneIDi 2614604.
    KEGGi vch:VC1171.
    PATRICi 20081434. VBIVibCho83274_1120.

    Phylogenomic databases

    eggNOGi COG0134.
    KOi K13498.
    OMAi EKYFQGD.
    OrthoDBi EOG6WT8JX.

    Enzyme and pathway databases

    UniPathwayi UPA00035 ; UER00042 .
    UPA00035 ; UER00043 .
    BioCyci VCHO:VC1171-MONOMER.

    Family and domain databases

    Gene3Di 3.20.20.70. 2 hits.
    HAMAPi MF_00134_B. IGPS_B.
    MF_00135. PRAI.
    InterProi IPR013785. Aldolase_TIM.
    IPR013798. Indole-3-glycerol_P_synth.
    IPR001468. Indole-3-GlycerolPSynthase_CS.
    IPR001240. PRAI_dom.
    IPR011060. RibuloseP-bd_barrel.
    [Graphical view ]
    Pfami PF00218. IGPS. 1 hit.
    PF00697. PRAI. 1 hit.
    [Graphical view ]
    SUPFAMi SSF51366. SSF51366. 2 hits.
    PROSITEi PS00614. IGPS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39315 / El Tor Inaba N16961.

    Entry informationi

    Entry nameiTRPC_VIBCH
    AccessioniPrimary (citable) accession number: Q9KST5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3