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Q9KST5

- TRPC_VIBCH

UniProt

Q9KST5 - TRPC_VIBCH

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Protein

Tryptophan biosynthesis protein TrpCF

Gene

trpCF

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Bifunctional enzyme that catalyzes two sequential steps of tryptophan biosynthetic pathway. The first reaction is catalyzed by the isomerase, coded by the TrpF domain; the second reaction is catalyzed by the synthase, coded by the TrpC domain (By similarity).By similarity

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.
1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O.

Pathwayi

GO - Molecular functioni

  1. indole-3-glycerol-phosphate synthase activity Source: TIGR
  2. phosphoribosylanthranilate isomerase activity Source: TIGR

GO - Biological processi

  1. tryptophan biosynthetic process Source: TIGR
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Isomerase, Lyase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciVCHO:VC1171-MONOMER.
UniPathwayiUPA00035; UER00042.
UPA00035; UER00043.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan biosynthesis protein TrpCF
Including the following 2 domains:
Indole-3-glycerol phosphate synthase (EC:4.1.1.48)
Short name:
IGPS
N-(5'-phospho-ribosyl)anthranilate isomerase (EC:5.3.1.24)
Short name:
PRAI
Gene namesi
Name:trpCF
Ordered Locus Names:VC_1171
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 469469Tryptophan biosynthesis protein TrpCFPRO_0000154285Add
BLAST

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

STRINGi243277.VC1171.

Structurei

3D structure databases

ProteinModelPortaliQ9KST5.
SMRiQ9KST5. Positions 16-469.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 271271Indole-3-glycerol phosphate synthaseAdd
BLAST
Regioni272 – 469198N-(5'-phosphoribosyl)anthranilate isomeraseAdd
BLAST

Sequence similaritiesi

In the N-terminal section; belongs to the TrpC family.Curated
In the C-terminal section; belongs to the TrpF family.Curated

Phylogenomic databases

eggNOGiCOG0134.
KOiK13498.
OMAiEKYFQGD.
OrthoDBiEOG6WT8JX.

Family and domain databases

Gene3Di3.20.20.70. 2 hits.
HAMAPiMF_00134_B. IGPS_B.
MF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00218. IGPS. 1 hit.
PF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 2 hits.
PROSITEiPS00614. IGPS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KST5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSEQLSEHIS VQTAQMAQVL VKIVNDKYQW IEERKAKQPL ASFHPLLTRS
60 70 80 90 100
ERDFYQALSG DNTVFILECK KASPSKGLIR EEFDLDYIAS VYGEYASAIS
110 120 130 140 150
VLTDEKYFQG RFEFLPQVRA QVAQPVLCKD FMVDPYQVYL ARHYQADAIL
160 170 180 190 200
LMLSVLNDDQ YRELAAVAHD LGMGVLTEVS NEQELKRAVD LQAKVIGINN
210 220 230 240 250
RNLRDLTTDL NRTKQLAPLI PQGTIIISES GIYTHQQVRD LAEFANGFLI
260 270 280 290 300
GSSLMAQSNL ELAVRKIVLG EHKVCGLTHP DDAVKAYQAG SVFGGLIFVE
310 320 330 340 350
KSKRFVDVEQ ARLTMSGAPL QYVGVFQNHP AAQVADIATK LGLFAVQLHG
360 370 380 390 400
EEDSAYVSEL RASLPESIEI WKAYGVSDAL PELLPEHIDR HLLDAKVGEQ
410 420 430 440 450
SGGTGRSFDW RLLPKHSDLM LAGGLSAENV AQAAQLGCRG LDFNSGVESA
460
PGKKDANQLQ QVFQQLRNY
Length:469
Mass (Da):52,038
Last modified:October 1, 2000 - v1
Checksum:iAAFF776A0D8EC66E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF94330.1.
PIRiF82232.
RefSeqiNP_230816.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF94330; AAF94330; VC_1171.
GeneIDi2614604.
KEGGivch:VC1171.
PATRICi20081434. VBIVibCho83274_1120.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF94330.1 .
PIRi F82232.
RefSeqi NP_230816.1. NC_002505.1.

3D structure databases

ProteinModelPortali Q9KST5.
SMRi Q9KST5. Positions 16-469.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243277.VC1171.

Protocols and materials databases

DNASUi 2614604.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF94330 ; AAF94330 ; VC_1171 .
GeneIDi 2614604.
KEGGi vch:VC1171.
PATRICi 20081434. VBIVibCho83274_1120.

Phylogenomic databases

eggNOGi COG0134.
KOi K13498.
OMAi EKYFQGD.
OrthoDBi EOG6WT8JX.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00042 .
UPA00035 ; UER00043 .
BioCyci VCHO:VC1171-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 2 hits.
HAMAPi MF_00134_B. IGPS_B.
MF_00135. PRAI.
InterProi IPR013785. Aldolase_TIM.
IPR013798. Indole-3-glycerol_P_synth.
IPR001468. Indole-3-GlycerolPSynthase_CS.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00218. IGPS. 1 hit.
PF00697. PRAI. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 2 hits.
PROSITEi PS00614. IGPS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.

Entry informationi

Entry nameiTRPC_VIBCH
AccessioniPrimary (citable) accession number: Q9KST5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: October 1, 2000
Last modified: October 1, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Multifunctional enzyme, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3