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Reviewed, UniProtKB/Swiss-Prot Q9KST2 (TRPE_VIBCH)

Last modified February 9, 2010. Version 60. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Anthranilate synthase component 1
    EC=4.1.3.27
Alternative name(s):
    Anthranilate synthase component I
Gene names
Name: trpE
Ordered Locus Names: VC_1174
OrganismVibrio cholerae [Complete proteome] [HAMAP]
Taxonomic identifier666 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length523 AA.
Sequence statusComplete.
Protein existenceInferred from homology.

General annotation (Comments)

Catalytic activity

Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.

Pathway

Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.

Subunit structure

Tetramer of two components I and two components II By similarity.

Miscellaneous

Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
Tryptophan biosynthesis
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processtryptophan biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionanthranilate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 523523Anthranilate synthase component 1
PRO_0000154118

Sequences

Sequence LengthMass (Da)Tools
Q9KST2-1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 0114149AC7665CDE

FASTA52358,118
        10         20         30         40         50         60 
MNKAINIKKT APLEVLHSEL PYTQDPTALF HALCAGRSDC LLLESAEIDS KQNLKSLLLV 

        70         80         90        100        110        120 
DAAVRIVCEG HQVTYHALSA NGQALLNIIH SNLTDRIPCK VEKAKLTLTF STPCDTLDED 

       130        140        150        160        170        180 
SRLREASSFD ALRLVQHSFD LTDHGKFALF LGGLFAYDLV ANFEPLGEAP ADNQCPDYVF 

       190        200        210        220        230        240 
YVAETLMVID HQRETCQLQA TQFQPGDALH SQLKSRMREI RAQVNQKLPL PSAQSLSDVE 

       250        260        270        280        290        300 
VTTNISDAAF CDIVRDLKQY VVKGDVFQVV PSRRFRLPCP SPLAAYQRLK QSNPSPYMFY 

       310        320        330        340        350        360 
MQDERFTLFG ASPESALKYE MHTNQVEIYP IAGTRRRGKR ADGSIDFDLD SRIELELRTD 

       370        380        390        400        410        420 
KKENAEHMML VDLARNDVAR ISQAGTRHVA DLLQVDRYSH VMHLVSRVVG QLREDLDALH 

       430        440        450        460        470        480 
AYQACMNMGT LTGAPKIRAM QLIRDVEQAR RGSYGGAVGY LTGEGDLDTC IVIRSAYVEN 

       490        500        510        520 
GIAQVQAGAG VVYDSDPQAE ADETRGKAQA VISAILYAHQ GKE 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE003852 Genomic DNA. Translation: AAF94333.1.
PIRA82233.
RefSeqNP_230819.1.

3D structure databases

SMRQ9KST2. Positions 13-521.
ModBaseSearch...

Genome annotation databases

GeneID2614607.
GenomeReviewsGene locus VC_1174 in contig AE003852_GR.
KEGGvch:VC1174.
TIGRVC_1174.

Phylogenomic databases

HOGENOMHBG507440.
OMAHKELAEH.

Enzyme and pathway databases

BRENDA4.1.3.27. 19019.

Family and domain databases

InterProIPR005801. ADC_synthase.
IPR006805. Anth_synth_I_N.
IPR019999. Anthranilate_synth_I_C.
IPR015890. Chorismate-bd_C.
IPR005257. TrpE_synth.
[Graphical view]
Gene3DG3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
PANTHERPTHR11236. TRPE_1_chor_bd. 1 hit.
PfamPF04715. Anth_synt_I_N. 1 hit.
PF00425. Chorismate_bind. 1 hit.
[Graphical view]
PRINTSPR00095. ANTSNTHASEI.
TIGRFAMsTIGR00565. trpE_proteo. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTRPE_VIBCH
AccessionPrimary (citable) accession number: Q9KST2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: October 1, 2000
Last modified: February 9, 2010
This is version 60 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents