Reviewed, UniProtKB/Swiss-Prot Q9KST2 (TRPE_VIBCH)

Names and origin

Protein names

Recommended name:
    Anthranilate synthase component 1
    EC=4.1.3.27
Alternative name(s):
    Anthranilate synthase component I

Gene names

Name:	trpE
Ordered Locus Names:	VC_1174

Organism

Vibrio cholerae [Complete proteome] [HAMAP]

Taxonomic identifier

666 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	523 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate.
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 1/5.
Subunit structure	Tetramer of two components I and two components II By similarity.
Miscellaneous	Component I catalyzes the formation of anthranilate using ammonia rather than glutamine, whereas component II provides glutamine amidotransferase activity.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	anthranilate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 523	523	Anthranilate synthase component 1		PRO_0000154118

Sequences

	Sequence		Length	Mass (Da)
	Q9KST2-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 0114149AC7665CDE	FASTA	523	58,118
	10 20 30 40 50 60 MNKAINIKKT APLEVLHSEL PYTQDPTALF HALCAGRSDC LLLESAEIDS KQNLKSLLLV 70 80 90 100 110 120 DAAVRIVCEG HQVTYHALSA NGQALLNIIH SNLTDRIPCK VEKAKLTLTF STPCDTLDED 130 140 150 160 170 180 SRLREASSFD ALRLVQHSFD LTDHGKFALF LGGLFAYDLV ANFEPLGEAP ADNQCPDYVF 190 200 210 220 230 240 YVAETLMVID HQRETCQLQA TQFQPGDALH SQLKSRMREI RAQVNQKLPL PSAQSLSDVE 250 260 270 280 290 300 VTTNISDAAF CDIVRDLKQY VVKGDVFQVV PSRRFRLPCP SPLAAYQRLK QSNPSPYMFY 310 320 330 340 350 360 MQDERFTLFG ASPESALKYE MHTNQVEIYP IAGTRRRGKR ADGSIDFDLD SRIELELRTD 370 380 390 400 410 420 KKENAEHMML VDLARNDVAR ISQAGTRHVA DLLQVDRYSH VMHLVSRVVG QLREDLDALH 430 440 450 460 470 480 AYQACMNMGT LTGAPKIRAM QLIRDVEQAR RGSYGGAVGY LTGEGDLDTC IVIRSAYVEN 490 500 510 520 GIAQVQAGAG VVYDSDPQAE ADETRGKAQA VISAILYAHQ GKE

References

[1]

"DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae." Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R., Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D., Vamathevan J.J., Bass S. , Qin H., Dragoi I., Sellers P., McDonald L.A., Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L., Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M. Nature 406:477-483(2000) [PubMed: 10952301] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 39315 / El Tor Inaba N16961 / Serotype O1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE003852 Genomic DNA. Translation: AAF94333.1.
PIR	A82233.
RefSeq	NP_230819.1.
3D structure databases
SMR	Q9KST2. Positions 13-521.
ModBase	Search...
Genome annotation databases
GeneID	2614607.
GenomeReviews	Gene locus VC_1174 in contig AE003852_GR.
KEGG	vch:VC1174.
TIGR	VC_1174.
Phylogenomic databases
HOGENOM	HBG507440.
OMA	HKELAEH.
Enzyme and pathway databases
BRENDA	4.1.3.27. 19019.
Family and domain databases
InterPro	IPR005801. ADC_synthase. IPR006805. Anth_synth_I_N. IPR019999. Anthranilate_synth_I_C. IPR015890. Chorismate-bd_C. IPR005257. TrpE_synth. [Graphical view]
Gene3D	G3DSA:3.60.120.10. TRPE_1_chor_bd. 1 hit.
PANTHER	PTHR11236. TRPE_1_chor_bd. 1 hit.
Pfam	PF04715. Anth_synt_I_N. 1 hit. PF00425. Chorismate_bind. 1 hit. [Graphical view]
PRINTS	PR00095. ANTSNTHASEI.
TIGRFAMs	TIGR00565. trpE_proteo. 1 hit.
ProtoNet	Search...

Entry information

Entry name

TRPE_VIBCH

Accession

Primary (citable) accession number: Q9KST2

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 20, 2001
Last sequence update:	October 1, 2000
Last modified:	February 9, 2010
This is version 60 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)