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Q9KSE5

- ALR2_VIBCH

UniProt

Q9KSE5 - ALR2_VIBCH

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Protein

Alanine racemase 2

Gene
alr2, VC_1312
Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity.UniRule annotation

Catalytic activityi

L-alanine = D-alanine.UniRule annotation

Cofactori

Pyridoxal phosphate By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei59 – 591Proton acceptor; specific for D-alanine By similarity
Binding sitei158 – 1581Substrate By similarity
Active sitei284 – 2841Proton acceptor; specific for L-alanine By similarity
Binding sitei332 – 3321Substrate; via amide nitrogen By similarity

GO - Molecular functioni

  1. alanine racemase activity Source: TIGR
  2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
  2. peptidoglycan biosynthetic process Source: TIGR
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

UniPathwayiUPA00042; UER00497.

Names & Taxonomyi

Protein namesi
Recommended name:
Alanine racemase 2 (EC:5.1.1.1)
Gene namesi
Name:alr2
Ordered Locus Names:VC_1312
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 392392Alanine racemase 2UniRule annotationPRO_0000114592Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei59 – 591N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Protein-protein interaction databases

STRINGi243277.VC1312.

Structurei

Secondary structure

1
392
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi20 – 245
Beta strandi26 – 338
Helixi34 – 4512
Beta strandi54 – 574
Helixi59 – 635
Helixi67 – 7610
Beta strandi81 – 866
Helixi87 – 959
Beta strandi100 – 1045
Helixi110 – 1156
Helixi117 – 1193
Beta strandi122 – 1254
Helixi128 – 14114
Beta strandi145 – 1517
Beta strandi158 – 1614
Helixi166 – 17611
Beta strandi181 – 1877
Helixi195 – 21521
Helixi220 – 2223
Beta strandi224 – 2285
Helixi230 – 2356
Helixi237 – 2393
Turni248 – 2525
Beta strandi264 – 2696
Beta strandi272 – 2765
Beta strandi281 – 2833
Helixi284 – 2863
Beta strandi294 – 3007
Helixi303 – 3053
Helixi309 – 3113
Turni312 – 3143
Beta strandi316 – 3194
Beta strandi322 – 3265
Beta strandi335 – 3384
Beta strandi350 – 3578
Helixi364 – 3718
Helixi375 – 38511
Beta strandi388 – 3914

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4BEQX-ray1.50A9-392[»]
4BEUX-ray1.15A9-392[»]
ProteinModelPortaliQ9KSE5.

Family & Domainsi

Sequence similaritiesi

Belongs to the alanine racemase family.

Phylogenomic databases

eggNOGiCOG0787.
OMAiQQIPCVA.
OrthoDBiEOG6PP9NJ.

Family and domain databases

Gene3Di2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPiMF_01201. Ala_racemase.
InterProiIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSiPR00992. ALARACEMASE.
SMARTiSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMiSSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR00492. alr. 1 hit.
PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KSE5-1 [UniParc]FASTAAdd to Basket

« Hide

MPSFSLSAAP LHIDTALPDA AQIQQSNSWL EISLGQFQSN IEQFKSHMNA    50
NTKICAIMKA DAYGNGIRGL MPTIIAQGIP CVGVASNAEA RAVRESGFKG 100
ELIRVRSASL SEMSSALDLN IEELIGTHQQ ALDLAELAKQ SGKTLKVHIA 150
LNDGGMGRNG IDMTTEAGKK EAVSIATQPS LSVVGIMTHF PNYNADEVRA 200
KLAQFKESST WLMQQANLKR EEITLHVANS YTALNVPEAQ LDMVRPGGVL 250
FGDLPTNPEY PSIVSFKTRV SSLHHLPKDS TVGYDSTFTT SRDSVLANLP 300
VGYSDGYPRK MGNKAEVLIN GQRAKVVGVT SMNTTVVDVT EIKGVLPGQE 350
VVLFGQQQKQ SIAVSEMENN AELIFPELYT LWGTSNPRFY VK 392
Length:392
Mass (Da):42,498
Last modified:March 5, 2002 - v2
Checksum:iC0211DC2661691FD
GO

Sequence cautioni

The sequence AAF94470.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003852 Genomic DNA. Translation: AAF94470.1. Different initiation.
PIRiA82215.

Genome annotation databases

EnsemblBacteriaiAAF94470; AAF94470; VC_1312.
PATRICi20081706. VBIVibCho83274_1252.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003852 Genomic DNA. Translation: AAF94470.1 . Different initiation.
PIRi A82215.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4BEQ X-ray 1.50 A 9-392 [» ]
4BEU X-ray 1.15 A 9-392 [» ]
ProteinModelPortali Q9KSE5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243277.VC1312.

Protocols and materials databases

DNASUi 2614766.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF94470 ; AAF94470 ; VC_1312 .
PATRICi 20081706. VBIVibCho83274_1252.

Phylogenomic databases

eggNOGi COG0787.
OMAi QQIPCVA.
OrthoDBi EOG6PP9NJ.

Enzyme and pathway databases

UniPathwayi UPA00042 ; UER00497 .

Family and domain databases

Gene3Di 2.40.37.10. 1 hit.
3.20.20.10. 1 hit.
HAMAPi MF_01201. Ala_racemase.
InterProi IPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view ]
PRINTSi PR00992. ALARACEMASE.
SMARTi SM01005. Ala_racemase_C. 1 hit.
[Graphical view ]
SUPFAMi SSF50621. SSF50621. 1 hit.
SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR00492. alr. 1 hit.
PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.

Entry informationi

Entry nameiALR2_VIBCH
AccessioniPrimary (citable) accession number: Q9KSE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: March 5, 2002
Last modified: June 11, 2014
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi