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Q9KSE5 (ALR2_VIBCH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 89. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alanine racemase 2

EC=5.1.1.1
Gene names
Name:alr2
Ordered Locus Names:VC_1312
OrganismVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) [Reference proteome] [HAMAP]
Taxonomic identifier243277 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length392 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids By similarity. HAMAP-Rule MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP-Rule MF_01201

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01201

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP-Rule MF_01201

Sequence similarities

Belongs to the alanine racemase family.

Sequence caution

The sequence AAF94470.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 392392Alanine racemase 2 HAMAP-Rule MF_01201
PRO_0000114592

Sites

Active site591Proton acceptor; specific for D-alanine By similarity
Active site2841Proton acceptor; specific for L-alanine By similarity
Binding site1581Substrate By similarity
Binding site3321Substrate; via amide nitrogen By similarity

Amino acid modifications

Modified residue591N6-(pyridoxal phosphate)lysine By similarity

Secondary structure

......................................................................... 392
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9KSE5 [UniParc].

Last modified March 5, 2002. Version 2.
Checksum: C0211DC2661691FD

FASTA39242,498
        10         20         30         40         50         60 
MPSFSLSAAP LHIDTALPDA AQIQQSNSWL EISLGQFQSN IEQFKSHMNA NTKICAIMKA 

        70         80         90        100        110        120 
DAYGNGIRGL MPTIIAQGIP CVGVASNAEA RAVRESGFKG ELIRVRSASL SEMSSALDLN 

       130        140        150        160        170        180 
IEELIGTHQQ ALDLAELAKQ SGKTLKVHIA LNDGGMGRNG IDMTTEAGKK EAVSIATQPS 

       190        200        210        220        230        240 
LSVVGIMTHF PNYNADEVRA KLAQFKESST WLMQQANLKR EEITLHVANS YTALNVPEAQ 

       250        260        270        280        290        300 
LDMVRPGGVL FGDLPTNPEY PSIVSFKTRV SSLHHLPKDS TVGYDSTFTT SRDSVLANLP 

       310        320        330        340        350        360 
VGYSDGYPRK MGNKAEVLIN GQRAKVVGVT SMNTTVVDVT EIKGVLPGQE VVLFGQQQKQ 

       370        380        390 
SIAVSEMENN AELIFPELYT LWGTSNPRFY VK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE003852 Genomic DNA. Translation: AAF94470.1. Different initiation.
PIRA82215.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4BEQX-ray1.50A9-392[»]
4BEUX-ray1.15A9-392[»]
ProteinModelPortalQ9KSE5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243277.VC1312.

Protocols and materials databases

DNASU2614766.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF94470; AAF94470; VC_1312.
PATRIC20081706. VBIVibCho83274_1252.

Phylogenomic databases

eggNOGCOG0787.
OMAADLYTVW.
OrthoDBEOG6PP9NJ.
ProtClustDBPRK13340.

Enzyme and pathway databases

UniPathwayUPA00042; UER00497.

Family and domain databases

Gene3D2.40.37.10. 1 hit.
HAMAPMF_01201. Ala_racemase.
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
[Graphical view]
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. SSF50621. 1 hit.
TIGRFAMsTIGR00492. alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALR2_VIBCH
AccessionPrimary (citable) accession number: Q9KSE5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: March 5, 2002
Last modified: April 16, 2014
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways