Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q9KSE5 (ALR2_VIBCH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Alanine racemase 2
EC=5.1.1.1
Gene names
Name:alr2
Ordered Locus Names:VC_1312
OrganismVibrio cholerae
Taxonomic identifier666 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length392 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Provides the D-alanine required for cell wall biosynthesis By similarity. HAMAP MF_01201

Catalytic activity

L-alanine = D-alanine. HAMAP MF_01201

Cofactor

Pyridoxal phosphate By similarity. HAMAP MF_01201

Pathway

Amino-acid biosynthesis; D-alanine biosynthesis; D-alanine from L-alanine: step 1/1. HAMAP MF_01201

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_01201

Sequence similarities

Belongs to the alanine racemase family.

Sequence caution

The sequence AAF94470.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 392392Alanine racemase 2 HAMAP MF_01201
PRO_0000114592

Sites

Active site591Proton acceptor; specific for D-alanine By similarity
Active site2841Proton acceptor; specific for L-alanine By similarity

Amino acid modifications

Modified residue591N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9KSE5 [UniParc].

Last modified March 5, 2002. Version 2.
Checksum: C0211DC2661691FD

FASTA39242,498
        10         20         30         40         50         60 
MPSFSLSAAP LHIDTALPDA AQIQQSNSWL EISLGQFQSN IEQFKSHMNA NTKICAIMKA 

        70         80         90        100        110        120 
DAYGNGIRGL MPTIIAQGIP CVGVASNAEA RAVRESGFKG ELIRVRSASL SEMSSALDLN 

       130        140        150        160        170        180 
IEELIGTHQQ ALDLAELAKQ SGKTLKVHIA LNDGGMGRNG IDMTTEAGKK EAVSIATQPS 

       190        200        210        220        230        240 
LSVVGIMTHF PNYNADEVRA KLAQFKESST WLMQQANLKR EEITLHVANS YTALNVPEAQ 

       250        260        270        280        290        300 
LDMVRPGGVL FGDLPTNPEY PSIVSFKTRV SSLHHLPKDS TVGYDSTFTT SRDSVLANLP 

       310        320        330        340        350        360 
VGYSDGYPRK MGNKAEVLIN GQRAKVVGVT SMNTTVVDVT EIKGVLPGQE VVLFGQQQKQ 

       370        380        390 
SIAVSEMENN AELIFPELYT LWGTSNPRFY VK

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE003852 Genomic DNA. Translation: AAF94470.1. Different initiation.
PIRA82215.
RefSeqNP_230956.2. NC_002505.1.

3D structure databases

ProteinModelPortalQ9KSE5.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2614766.
GenomeReviewsGene locus VC_1312 in contig AE003852_GR.
KEGGvch:VC1312.
PATRIC20081706. VBIVibCho83274_1252.
TIGRVC_1312.

Phylogenomic databases

HOGENOMHBG291652.
OMANTVGYDR.
ProtClustDBPRK13340.

Family and domain databases

HAMAPMF_01201. Ala_racemase.
[Tree]
InterProIPR000821. Ala_racemase.
IPR009006. Ala_racemase/Decarboxylase_C.
IPR011079. Ala_racemase_C.
IPR001608. Ala_racemase_N.
IPR020622. Ala_racemase_pyridoxalP-BS.
[Graphical view]
Gene3DG3DSA:2.40.37.10. Ala_racemase/Decarboxylase_C. 1 hit.
KOK01775.
PfamPF00842. Ala_racemase_C. 1 hit.
PF01168. Ala_racemase_N. 1 hit.
[Graphical view]
PRINTSPR00992. ALARACEMASE.
SMARTSM01005. Ala_racemase_C. 1 hit.
[Graphical view]
SUPFAMSSF50621. Racem_decarbox_C. 1 hit.
TIGRFAMsTIGR00492. Alr. 1 hit.
PROSITEPS00395. ALANINE_RACEMASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameALR2_VIBCH
AccessionPrimary (citable) accession number: Q9KSE5
Entry history
Integrated into UniProtKB/Swiss-Prot: March 5, 2002
Last sequence update: March 5, 2002
Last modified: January 25, 2012
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents