Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q9KSE5

- ALR2_VIBCH

UniProt

Q9KSE5 - ALR2_VIBCH

Protein

Alanine racemase 2

Gene

alr2

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 92 (01 Oct 2014)
      Sequence version 2 (05 Mar 2002)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids.UniRule annotation

    Catalytic activityi

    L-alanine = D-alanine.UniRule annotation

    Cofactori

    Pyridoxal phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei59 – 591Proton acceptor; specific for D-alanineUniRule annotation
    Binding sitei158 – 1581SubstrateUniRule annotation
    Active sitei284 – 2841Proton acceptor; specific for L-alanineUniRule annotation
    Binding sitei332 – 3321Substrate; via amide nitrogenUniRule annotation

    GO - Molecular functioni

    1. alanine racemase activity Source: TIGR
    2. pyridoxal phosphate binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. D-alanine biosynthetic process Source: UniProtKB-UniPathway
    2. peptidoglycan biosynthetic process Source: TIGR

    Keywords - Molecular functioni

    Isomerase

    Keywords - Ligandi

    Pyridoxal phosphate

    Enzyme and pathway databases

    UniPathwayiUPA00042; UER00497.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Alanine racemase 2UniRule annotation (EC:5.1.1.1UniRule annotation)
    Gene namesi
    Name:alr2
    Ordered Locus Names:VC_1312
    OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
    Taxonomic identifieri243277 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000000584: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 392392Alanine racemase 2PRO_0000114592Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei59 – 591N6-(pyridoxal phosphate)lysineUniRule annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi243277.VC1312.

    Structurei

    Secondary structure

    1
    392
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi20 – 245
    Beta strandi26 – 338
    Helixi34 – 4512
    Beta strandi54 – 574
    Helixi59 – 635
    Helixi67 – 7610
    Beta strandi81 – 866
    Helixi87 – 959
    Beta strandi100 – 1045
    Helixi110 – 1156
    Helixi117 – 1193
    Beta strandi122 – 1254
    Helixi128 – 14114
    Beta strandi145 – 1517
    Beta strandi158 – 1614
    Helixi166 – 17611
    Beta strandi181 – 1877
    Helixi195 – 21521
    Helixi220 – 2223
    Beta strandi224 – 2285
    Helixi230 – 2356
    Helixi237 – 2393
    Turni248 – 2525
    Beta strandi264 – 2696
    Beta strandi272 – 2765
    Beta strandi281 – 2833
    Helixi284 – 2863
    Beta strandi294 – 3007
    Helixi303 – 3053
    Helixi309 – 3113
    Turni312 – 3143
    Beta strandi316 – 3194
    Beta strandi322 – 3265
    Beta strandi335 – 3384
    Beta strandi350 – 3578
    Helixi364 – 3718
    Helixi375 – 38511
    Beta strandi388 – 3914

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4BEQX-ray1.50A9-392[»]
    4BEUX-ray1.15A9-392[»]
    ProteinModelPortaliQ9KSE5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the alanine racemase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0787.
    OMAiQQIPCVA.
    OrthoDBiEOG6PP9NJ.

    Family and domain databases

    Gene3Di2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPiMF_01201. Ala_racemase.
    InterProiIPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view]
    PfamiPF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view]
    PRINTSiPR00992. ALARACEMASE.
    SMARTiSM01005. Ala_racemase_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsiTIGR00492. alr. 1 hit.
    PROSITEiPS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9KSE5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPSFSLSAAP LHIDTALPDA AQIQQSNSWL EISLGQFQSN IEQFKSHMNA    50
    NTKICAIMKA DAYGNGIRGL MPTIIAQGIP CVGVASNAEA RAVRESGFKG 100
    ELIRVRSASL SEMSSALDLN IEELIGTHQQ ALDLAELAKQ SGKTLKVHIA 150
    LNDGGMGRNG IDMTTEAGKK EAVSIATQPS LSVVGIMTHF PNYNADEVRA 200
    KLAQFKESST WLMQQANLKR EEITLHVANS YTALNVPEAQ LDMVRPGGVL 250
    FGDLPTNPEY PSIVSFKTRV SSLHHLPKDS TVGYDSTFTT SRDSVLANLP 300
    VGYSDGYPRK MGNKAEVLIN GQRAKVVGVT SMNTTVVDVT EIKGVLPGQE 350
    VVLFGQQQKQ SIAVSEMENN AELIFPELYT LWGTSNPRFY VK 392
    Length:392
    Mass (Da):42,498
    Last modified:March 5, 2002 - v2
    Checksum:iC0211DC2661691FD
    GO

    Sequence cautioni

    The sequence AAF94470.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE003852 Genomic DNA. Translation: AAF94470.1. Different initiation.
    PIRiA82215.

    Genome annotation databases

    EnsemblBacteriaiAAF94470; AAF94470; VC_1312.
    PATRICi20081706. VBIVibCho83274_1252.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE003852 Genomic DNA. Translation: AAF94470.1 . Different initiation.
    PIRi A82215.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4BEQ X-ray 1.50 A 9-392 [» ]
    4BEU X-ray 1.15 A 9-392 [» ]
    ProteinModelPortali Q9KSE5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243277.VC1312.

    Protocols and materials databases

    DNASUi 2614766.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF94470 ; AAF94470 ; VC_1312 .
    PATRICi 20081706. VBIVibCho83274_1252.

    Phylogenomic databases

    eggNOGi COG0787.
    OMAi QQIPCVA.
    OrthoDBi EOG6PP9NJ.

    Enzyme and pathway databases

    UniPathwayi UPA00042 ; UER00497 .

    Family and domain databases

    Gene3Di 2.40.37.10. 1 hit.
    3.20.20.10. 1 hit.
    HAMAPi MF_01201. Ala_racemase.
    InterProi IPR000821. Ala_racemase.
    IPR009006. Ala_racemase/Decarboxylase_C.
    IPR011079. Ala_racemase_C.
    IPR001608. Ala_racemase_N.
    IPR020622. Ala_racemase_pyridoxalP-BS.
    IPR029066. PLP-binding_barrel.
    [Graphical view ]
    Pfami PF00842. Ala_racemase_C. 1 hit.
    PF01168. Ala_racemase_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00992. ALARACEMASE.
    SMARTi SM01005. Ala_racemase_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF50621. SSF50621. 1 hit.
    SSF51419. SSF51419. 1 hit.
    TIGRFAMsi TIGR00492. alr. 1 hit.
    PROSITEi PS00395. ALANINE_RACEMASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39315 / El Tor Inaba N16961.

    Entry informationi

    Entry nameiALR2_VIBCH
    AccessioniPrimary (citable) accession number: Q9KSE5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 5, 2002
    Last sequence update: March 5, 2002
    Last modified: October 1, 2014
    This is version 92 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3