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Protein

Chemotaxis protein methyltransferase 2

Gene

cheR2

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Methylation of the membrane-bound methyl-accepting chemotaxis proteins (MCP) to form gamma-glutamyl methyl ester residues in MCP.By similarity

Catalytic activityi

S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate methyl ester.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei76 – 761S-adenosyl-L-methionineBy similarity
Binding sitei78 – 781S-adenosyl-L-methionineBy similarity
Binding sitei82 – 821S-adenosyl-L-methionineBy similarity
Binding sitei119 – 1191S-adenosyl-L-methionineBy similarity
Binding sitei145 – 1451S-adenosyl-L-methionineBy similarity

GO - Molecular functioni

GO - Biological processi

  • chemotaxis Source: TIGR
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Ligandi

S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciVCHO:VC1399-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis protein methyltransferase 2 (EC:2.1.1.80)
Gene namesi
Name:cheR2
Ordered Locus Names:VC_1399
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000000584 Componenti: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 288288Chemotaxis protein methyltransferase 2PRO_0000176043Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243277.VC1399.

Structurei

3D structure databases

ProteinModelPortaliQ9KS61.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 280280CheR-type methyltransferasePROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni200 – 2012S-adenosyl-L-methionine bindingBy similarity
Regioni219 – 2202S-adenosyl-L-methionine bindingBy similarity

Sequence similaritiesi

Contains 1 cheR-type methyltransferase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
KOiK00575.
OMAiYFFREEY.

Family and domain databases

Gene3Di1.10.155.10. 1 hit.
3.40.50.150. 1 hit.
InterProiIPR026024. Chemotaxis_MeTrfase_CheR.
IPR022642. CheR_C.
IPR000780. CheR_MeTrfase.
IPR022641. CheR_N.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01739. CheR. 1 hit.
PF03705. CheR_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000410. CheR. 1 hit.
PRINTSiPR00996. CHERMTFRASE.
SMARTiSM00138. MeTrc. 1 hit.
[Graphical view]
SUPFAMiSSF47757. SSF47757. 1 hit.
SSF53335. SSF53335. 1 hit.
PROSITEiPS50123. CHER. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KS61-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNEIVITDTD FCRFRDYFYQ KTGIFFENSK RYFVDKRLLQ RIELTEHQSF
60 70 80 90 100
RGYFTYLRFQ ASGEELQAVI NALTVNETYF FREISQLESL VEEVLDDIVR
110 120 130 140 150
HRPGELIRIW SMPCSSGEEP YSIVLFLLEH WPKLEQVDIE IIASDIDTGI
160 170 180 190 200
LQKAAQGIFS ARSVKNLPNS SLNKYFSLRA DGSYQLIDDI RQSVRFTQTN
210 220 230 240 250
LNNRAEVQKL GAMDVIFCRN LLIYFDDISR RNAVESFYEQ LNPGGVLFLG
260 270 280
HSESMSRISS IFHVKRFRKS TGYYKPHKGK SDEKSNGR
Length:288
Mass (Da):33,631
Last modified:October 1, 2000 - v1
Checksum:i84CFE420653B7300
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF94556.1.
PIRiG82205.
RefSeqiNP_231042.1. NC_002505.1.
WP_001002908.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF94556; AAF94556; VC_1399.
GeneIDi2614031.
KEGGivch:VC1399.
PATRICi20081862. VBIVibCho83274_1330.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF94556.1.
PIRiG82205.
RefSeqiNP_231042.1. NC_002505.1.
WP_001002908.1. NC_002505.1.

3D structure databases

ProteinModelPortaliQ9KS61.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243277.VC1399.

Protocols and materials databases

DNASUi2614031.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF94556; AAF94556; VC_1399.
GeneIDi2614031.
KEGGivch:VC1399.
PATRICi20081862. VBIVibCho83274_1330.

Phylogenomic databases

eggNOGiENOG4105BZU. Bacteria.
ENOG410XNMH. LUCA.
KOiK00575.
OMAiYFFREEY.

Enzyme and pathway databases

BioCyciVCHO:VC1399-MONOMER.

Family and domain databases

Gene3Di1.10.155.10. 1 hit.
3.40.50.150. 1 hit.
InterProiIPR026024. Chemotaxis_MeTrfase_CheR.
IPR022642. CheR_C.
IPR000780. CheR_MeTrfase.
IPR022641. CheR_N.
IPR029063. SAM-dependent_MTases.
[Graphical view]
PfamiPF01739. CheR. 1 hit.
PF03705. CheR_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000410. CheR. 1 hit.
PRINTSiPR00996. CHERMTFRASE.
SMARTiSM00138. MeTrc. 1 hit.
[Graphical view]
SUPFAMiSSF47757. SSF47757. 1 hit.
SSF53335. SSF53335. 1 hit.
PROSITEiPS50123. CHER. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCHER2_VIBCH
AccessioniPrimary (citable) accession number: Q9KS61
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: October 1, 2000
Last modified: September 7, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.