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Q9KRZ5

- RLMKL_VIBCH

UniProt

Q9KRZ5 - RLMKL_VIBCH

Protein

Ribosomal RNA large subunit methyltransferase K/L

Gene

rlmL

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.UniRule annotation

    Catalytic activityi

    S-adenosyl-L-methionine + guanine(2445) in 23S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanine(2445) in 23S rRNA.UniRule annotation
    S-adenosyl-L-methionine + guanine(2069) in 23S rRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(2069) in 23S rRNA.UniRule annotation

    GO - Molecular functioni

    1. 23S rRNA (guanine(2445)-N(2))-methyltransferase activity Source: UniProtKB-HAMAP
    2. RNA binding Source: UniProtKB-HAMAP
    3. rRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Methyltransferase, Transferase

    Keywords - Biological processi

    rRNA processing

    Keywords - Ligandi

    RNA-binding, S-adenosyl-L-methionine

    Enzyme and pathway databases

    BioCyciVCHO:VC1488-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Ribosomal RNA large subunit methyltransferase K/LUniRule annotation
    Including the following 2 domains:
    23S rRNA m2G2445 methyltransferaseUniRule annotation (EC:2.1.1.173UniRule annotation)
    Alternative name(s):
    rRNA (guanine-N(2)-)-methyltransferase RlmLUniRule annotation
    23S rRNA m7G2069 methyltransferaseUniRule annotation (EC:2.1.1.264UniRule annotation)
    Alternative name(s):
    rRNA (guanine-N(7)-)-methyltransferase RlmKUniRule annotation
    Gene namesi
    Name:rlmLUniRule annotation
    Ordered Locus Names:VC_1488
    OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
    Taxonomic identifieri243277 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000000584: Chromosome 1

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 708708Ribosomal RNA large subunit methyltransferase K/LPRO_0000366846Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243277.VC1488.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9KRZ5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini43 – 154112THUMPUniRule annotationAdd
    BLAST

    Sequence similaritiesi

    Belongs to the methyltransferase superfamily. RlmKL family.UniRule annotation
    Contains 1 THUMP domain.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0116.
    KOiK12297.
    OMAiNKRGFKM.
    OrthoDBiEOG6HJ238.

    Family and domain databases

    Gene3Di3.40.50.150. 3 hits.
    HAMAPiMF_01858. 23SrRNA_methyltr_KL.
    InterProiIPR017244. 23SrRNA_methyltr_KL.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR000241. RNA_methylase_dom.
    IPR019614. SAM-dep_methyl-trfase.
    IPR029063. SAM-dependent_MTases-like.
    IPR004114. THUMP.
    [Graphical view]
    PfamiPF10672. Methyltrans_SAM. 1 hit.
    PF02926. THUMP. 1 hit.
    PF01170. UPF0020. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037618. RNA_Mtase_bacteria_prd. 1 hit.
    SMARTiSM00981. THUMP. 1 hit.
    [Graphical view]
    SUPFAMiSSF53335. SSF53335. 3 hits.
    PROSITEiPS51165. THUMP. 1 hit.
    PS01261. UPF0020. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9KRZ5-1 [UniParc]FASTAAdd to Basket

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    MNQYLAVTSN GLENLLVEEL TQLGINDAKP VQAGVKFKAT NEQIYRCCLW    50
    SRLASRFVRI VAEFKCQNDL DLYLSTTSVN WVNYFHSSKK LVVDFNGTNR 100
    EIRNSQYGAM KVKDAIVDCF TKKNLPRPSI SKDLADLHIH VRLHKENALL 150
    GIDMVGSGLH ARGYRTEAGK APLRETLAAA IILRSGWDAS KPLLDPMCGS 200
    GTLLIEAAMM AANIAPGLQR KKWGFEALED FEPELWASVK SEASVQGKRG 250
    VKKVETHFYG VDNDNRVLQT AKDNARRAGV EELISFTLGD AAKVKRPENF 300
    AEGIVICNPP YGERLGTHPG LIALYTAFGA QLKAEFGGCH ASIFSSSDEL 350
    LSCLRMRADK QFKLNNGALP CHQKNYTIAM REQNSVSNEG TQEILIAPDF 400
    ANRLKKNFNK IGKWAKREGL DCFRLYDADL PEYNVAIDVY QDHLMIQEYA 450
    APKDIPEEKA KRRLTDIIRA AIQVLDVDAN NVVLKVRERQ KGTSQYEKLG 500
    QQAQTMQITE YGVKLIVNLY DYLDTGLFLD HKITRRRLGQ MAQGKDFLNL 550
    FAYTGSATVH AACGGAKSTT TVDMSKTYLE WAKENMQLNG QVGRQHQYVQ 600
    ADCLQWLANA QSQYDLIFID PPTFSNSKRM EQTFDVQRDH VTLMTNLKRL 650
    LRPEGTIVFS NNKRHFKMDM EALHALGLNA QNISHQTLPL DFERNKQIHN 700
    CWLITHQS 708
    Length:708
    Mass (Da):79,833
    Last modified:October 1, 2000 - v1
    Checksum:i80C9C366AA5ADB8F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE003852 Genomic DNA. Translation: AAF94643.1.
    PIRiA82195.
    RefSeqiNP_231129.1. NC_002505.1.

    Genome annotation databases

    EnsemblBacteriaiAAF94643; AAF94643; VC_1488.
    GeneIDi2613994.
    KEGGivch:VC1488.
    PATRICi20082034. VBIVibCho83274_1416.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE003852 Genomic DNA. Translation: AAF94643.1 .
    PIRi A82195.
    RefSeqi NP_231129.1. NC_002505.1.

    3D structure databases

    ProteinModelPortali Q9KRZ5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243277.VC1488.

    Protocols and materials databases

    DNASUi 2613994.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF94643 ; AAF94643 ; VC_1488 .
    GeneIDi 2613994.
    KEGGi vch:VC1488.
    PATRICi 20082034. VBIVibCho83274_1416.

    Phylogenomic databases

    eggNOGi COG0116.
    KOi K12297.
    OMAi NKRGFKM.
    OrthoDBi EOG6HJ238.

    Enzyme and pathway databases

    BioCyci VCHO:VC1488-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.150. 3 hits.
    HAMAPi MF_01858. 23SrRNA_methyltr_KL.
    InterProi IPR017244. 23SrRNA_methyltr_KL.
    IPR002052. DNA_methylase_N6_adenine_CS.
    IPR000241. RNA_methylase_dom.
    IPR019614. SAM-dep_methyl-trfase.
    IPR029063. SAM-dependent_MTases-like.
    IPR004114. THUMP.
    [Graphical view ]
    Pfami PF10672. Methyltrans_SAM. 1 hit.
    PF02926. THUMP. 1 hit.
    PF01170. UPF0020. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037618. RNA_Mtase_bacteria_prd. 1 hit.
    SMARTi SM00981. THUMP. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53335. SSF53335. 3 hits.
    PROSITEi PS51165. THUMP. 1 hit.
    PS01261. UPF0020. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39315 / El Tor Inaba N16961.

    Entry informationi

    Entry nameiRLMKL_VIBCH
    AccessioniPrimary (citable) accession number: Q9KRZ5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: March 24, 2009
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3