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Q9KRZ5

- RLMKL_VIBCH

UniProt

Q9KRZ5 - RLMKL_VIBCH

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Protein

Ribosomal RNA large subunit methyltransferase K/L

Gene
rlmL, VC_1488
Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA By similarity.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(2445) in 23S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanine(2445) in 23S rRNA.UniRule annotation
S-adenosyl-L-methionine + guanine(2069) in 23S rRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(2069) in 23S rRNA.UniRule annotation

GO - Molecular functioni

  1. 23S rRNA (guanine(2445)-N(2))-methyltransferase activity Source: UniProtKB-HAMAP
  2. RNA binding Source: UniProtKB-HAMAP
  3. rRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciVCHO:VC1488-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase K/L
Including the following 2 domains:
23S rRNA m2G2445 methyltransferase (EC:2.1.1.173)
Alternative name(s):
rRNA (guanine-N(2)-)-methyltransferase RlmL
23S rRNA m7G2069 methyltransferase (EC:2.1.1.264)
Alternative name(s):
rRNA (guanine-N(7)-)-methyltransferase RlmK
Gene namesi
Name:rlmL
Ordered Locus Names:VC_1488
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584: Chromosome 1

Subcellular locationi

Cytoplasm Reviewed prediction UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 708708Ribosomal RNA large subunit methyltransferase K/LUniRule annotationPRO_0000366846Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243277.VC1488.

Structurei

3D structure databases

ProteinModelPortaliQ9KRZ5.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 154112THUMPAdd
BLAST

Sequence similaritiesi

Contains 1 THUMP domain.

Phylogenomic databases

eggNOGiCOG0116.
KOiK12297.
OMAiNKRGFKM.
OrthoDBiEOG6HJ238.

Family and domain databases

Gene3Di3.40.50.150. 3 hits.
HAMAPiMF_01858. 23SrRNA_methyltr_KL.
InterProiIPR017244. 23SrRNA_methyltr_KL.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR000241. RNA_methylase_dom.
IPR019614. SAM-dep_methyl-trfase.
IPR029063. SAM-dependent_MTases-like.
IPR004114. THUMP.
[Graphical view]
PfamiPF10672. Methyltrans_SAM. 1 hit.
PF02926. THUMP. 1 hit.
PF01170. UPF0020. 1 hit.
[Graphical view]
PIRSFiPIRSF037618. RNA_Mtase_bacteria_prd. 1 hit.
SMARTiSM00981. THUMP. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 3 hits.
PROSITEiPS51165. THUMP. 1 hit.
PS01261. UPF0020. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KRZ5-1 [UniParc]FASTAAdd to Basket

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MNQYLAVTSN GLENLLVEEL TQLGINDAKP VQAGVKFKAT NEQIYRCCLW    50
SRLASRFVRI VAEFKCQNDL DLYLSTTSVN WVNYFHSSKK LVVDFNGTNR 100
EIRNSQYGAM KVKDAIVDCF TKKNLPRPSI SKDLADLHIH VRLHKENALL 150
GIDMVGSGLH ARGYRTEAGK APLRETLAAA IILRSGWDAS KPLLDPMCGS 200
GTLLIEAAMM AANIAPGLQR KKWGFEALED FEPELWASVK SEASVQGKRG 250
VKKVETHFYG VDNDNRVLQT AKDNARRAGV EELISFTLGD AAKVKRPENF 300
AEGIVICNPP YGERLGTHPG LIALYTAFGA QLKAEFGGCH ASIFSSSDEL 350
LSCLRMRADK QFKLNNGALP CHQKNYTIAM REQNSVSNEG TQEILIAPDF 400
ANRLKKNFNK IGKWAKREGL DCFRLYDADL PEYNVAIDVY QDHLMIQEYA 450
APKDIPEEKA KRRLTDIIRA AIQVLDVDAN NVVLKVRERQ KGTSQYEKLG 500
QQAQTMQITE YGVKLIVNLY DYLDTGLFLD HKITRRRLGQ MAQGKDFLNL 550
FAYTGSATVH AACGGAKSTT TVDMSKTYLE WAKENMQLNG QVGRQHQYVQ 600
ADCLQWLANA QSQYDLIFID PPTFSNSKRM EQTFDVQRDH VTLMTNLKRL 650
LRPEGTIVFS NNKRHFKMDM EALHALGLNA QNISHQTLPL DFERNKQIHN 700
CWLITHQS 708
Length:708
Mass (Da):79,833
Last modified:October 1, 2000 - v1
Checksum:i80C9C366AA5ADB8F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003852 Genomic DNA. Translation: AAF94643.1.
PIRiA82195.
RefSeqiNP_231129.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF94643; AAF94643; VC_1488.
GeneIDi2613994.
KEGGivch:VC1488.
PATRICi20082034. VBIVibCho83274_1416.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003852 Genomic DNA. Translation: AAF94643.1 .
PIRi A82195.
RefSeqi NP_231129.1. NC_002505.1.

3D structure databases

ProteinModelPortali Q9KRZ5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243277.VC1488.

Protocols and materials databases

DNASUi 2613994.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF94643 ; AAF94643 ; VC_1488 .
GeneIDi 2613994.
KEGGi vch:VC1488.
PATRICi 20082034. VBIVibCho83274_1416.

Phylogenomic databases

eggNOGi COG0116.
KOi K12297.
OMAi NKRGFKM.
OrthoDBi EOG6HJ238.

Enzyme and pathway databases

BioCyci VCHO:VC1488-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 3 hits.
HAMAPi MF_01858. 23SrRNA_methyltr_KL.
InterProi IPR017244. 23SrRNA_methyltr_KL.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR000241. RNA_methylase_dom.
IPR019614. SAM-dep_methyl-trfase.
IPR029063. SAM-dependent_MTases-like.
IPR004114. THUMP.
[Graphical view ]
Pfami PF10672. Methyltrans_SAM. 1 hit.
PF02926. THUMP. 1 hit.
PF01170. UPF0020. 1 hit.
[Graphical view ]
PIRSFi PIRSF037618. RNA_Mtase_bacteria_prd. 1 hit.
SMARTi SM00981. THUMP. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 3 hits.
PROSITEi PS51165. THUMP. 1 hit.
PS01261. UPF0020. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.

Entry informationi

Entry nameiRLMKL_VIBCH
AccessioniPrimary (citable) accession number: Q9KRZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: October 1, 2000
Last modified: June 11, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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