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Q9KRZ5

- RLMKL_VIBCH

UniProt

Q9KRZ5 - RLMKL_VIBCH

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Protein

Ribosomal RNA large subunit methyltransferase K/L

Gene

rlmL

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA.UniRule annotation

Catalytic activityi

S-adenosyl-L-methionine + guanine(2445) in 23S rRNA = S-adenosyl-L-homocysteine + N(2)-methylguanine(2445) in 23S rRNA.UniRule annotation
S-adenosyl-L-methionine + guanine(2069) in 23S rRNA = S-adenosyl-L-homocysteine + N(7)-methylguanine(2069) in 23S rRNA.UniRule annotation

GO - Molecular functioni

  1. 23S rRNA (guanine(2445)-N(2))-methyltransferase activity Source: UniProtKB-HAMAP
  2. RNA binding Source: UniProtKB-HAMAP
  3. rRNA (guanine-N7-)-methyltransferase activity Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Methyltransferase, Transferase

Keywords - Biological processi

rRNA processing

Keywords - Ligandi

RNA-binding, S-adenosyl-L-methionine

Enzyme and pathway databases

BioCyciVCHO:VC1488-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribosomal RNA large subunit methyltransferase K/LUniRule annotation
Including the following 2 domains:
23S rRNA m2G2445 methyltransferaseUniRule annotation (EC:2.1.1.173UniRule annotation)
Alternative name(s):
rRNA (guanine-N(2)-)-methyltransferase RlmLUniRule annotation
23S rRNA m7G2069 methyltransferaseUniRule annotation (EC:2.1.1.264UniRule annotation)
Alternative name(s):
rRNA (guanine-N(7)-)-methyltransferase RlmKUniRule annotation
Gene namesi
Name:rlmLUniRule annotation
Ordered Locus Names:VC_1488
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584: Chromosome 1

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 708708Ribosomal RNA large subunit methyltransferase K/LPRO_0000366846Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243277.VC1488.

Structurei

3D structure databases

ProteinModelPortaliQ9KRZ5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 154112THUMPUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the methyltransferase superfamily. RlmKL family.UniRule annotation
Contains 1 THUMP domain.UniRule annotation

Phylogenomic databases

eggNOGiCOG0116.
KOiK12297.
OMAiNKRGFKM.
OrthoDBiEOG6HJ238.

Family and domain databases

Gene3Di3.40.50.150. 3 hits.
HAMAPiMF_01858. 23SrRNA_methyltr_KL.
InterProiIPR017244. 23SrRNA_methyltr_KL.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR000241. RNA_methylase_dom.
IPR019614. SAM-dep_methyl-trfase.
IPR029063. SAM-dependent_MTases-like.
IPR004114. THUMP.
[Graphical view]
PfamiPF10672. Methyltrans_SAM. 1 hit.
PF02926. THUMP. 1 hit.
PF01170. UPF0020. 1 hit.
[Graphical view]
PIRSFiPIRSF037618. RNA_Mtase_bacteria_prd. 1 hit.
SMARTiSM00981. THUMP. 1 hit.
[Graphical view]
SUPFAMiSSF53335. SSF53335. 3 hits.
PROSITEiPS51165. THUMP. 1 hit.
PS01261. UPF0020. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KRZ5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNQYLAVTSN GLENLLVEEL TQLGINDAKP VQAGVKFKAT NEQIYRCCLW
60 70 80 90 100
SRLASRFVRI VAEFKCQNDL DLYLSTTSVN WVNYFHSSKK LVVDFNGTNR
110 120 130 140 150
EIRNSQYGAM KVKDAIVDCF TKKNLPRPSI SKDLADLHIH VRLHKENALL
160 170 180 190 200
GIDMVGSGLH ARGYRTEAGK APLRETLAAA IILRSGWDAS KPLLDPMCGS
210 220 230 240 250
GTLLIEAAMM AANIAPGLQR KKWGFEALED FEPELWASVK SEASVQGKRG
260 270 280 290 300
VKKVETHFYG VDNDNRVLQT AKDNARRAGV EELISFTLGD AAKVKRPENF
310 320 330 340 350
AEGIVICNPP YGERLGTHPG LIALYTAFGA QLKAEFGGCH ASIFSSSDEL
360 370 380 390 400
LSCLRMRADK QFKLNNGALP CHQKNYTIAM REQNSVSNEG TQEILIAPDF
410 420 430 440 450
ANRLKKNFNK IGKWAKREGL DCFRLYDADL PEYNVAIDVY QDHLMIQEYA
460 470 480 490 500
APKDIPEEKA KRRLTDIIRA AIQVLDVDAN NVVLKVRERQ KGTSQYEKLG
510 520 530 540 550
QQAQTMQITE YGVKLIVNLY DYLDTGLFLD HKITRRRLGQ MAQGKDFLNL
560 570 580 590 600
FAYTGSATVH AACGGAKSTT TVDMSKTYLE WAKENMQLNG QVGRQHQYVQ
610 620 630 640 650
ADCLQWLANA QSQYDLIFID PPTFSNSKRM EQTFDVQRDH VTLMTNLKRL
660 670 680 690 700
LRPEGTIVFS NNKRHFKMDM EALHALGLNA QNISHQTLPL DFERNKQIHN

CWLITHQS
Length:708
Mass (Da):79,833
Last modified:October 1, 2000 - v1
Checksum:i80C9C366AA5ADB8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF94643.1.
PIRiA82195.
RefSeqiNP_231129.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF94643; AAF94643; VC_1488.
GeneIDi2613994.
KEGGivch:VC1488.
PATRICi20082034. VBIVibCho83274_1416.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF94643.1 .
PIRi A82195.
RefSeqi NP_231129.1. NC_002505.1.

3D structure databases

ProteinModelPortali Q9KRZ5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243277.VC1488.

Protocols and materials databases

DNASUi 2613994.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF94643 ; AAF94643 ; VC_1488 .
GeneIDi 2613994.
KEGGi vch:VC1488.
PATRICi 20082034. VBIVibCho83274_1416.

Phylogenomic databases

eggNOGi COG0116.
KOi K12297.
OMAi NKRGFKM.
OrthoDBi EOG6HJ238.

Enzyme and pathway databases

BioCyci VCHO:VC1488-MONOMER.

Family and domain databases

Gene3Di 3.40.50.150. 3 hits.
HAMAPi MF_01858. 23SrRNA_methyltr_KL.
InterProi IPR017244. 23SrRNA_methyltr_KL.
IPR002052. DNA_methylase_N6_adenine_CS.
IPR000241. RNA_methylase_dom.
IPR019614. SAM-dep_methyl-trfase.
IPR029063. SAM-dependent_MTases-like.
IPR004114. THUMP.
[Graphical view ]
Pfami PF10672. Methyltrans_SAM. 1 hit.
PF02926. THUMP. 1 hit.
PF01170. UPF0020. 1 hit.
[Graphical view ]
PIRSFi PIRSF037618. RNA_Mtase_bacteria_prd. 1 hit.
SMARTi SM00981. THUMP. 1 hit.
[Graphical view ]
SUPFAMi SSF53335. SSF53335. 3 hits.
PROSITEi PS51165. THUMP. 1 hit.
PS01261. UPF0020. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.

Entry informationi

Entry nameiRLMKL_VIBCH
AccessioniPrimary (citable) accession number: Q9KRZ5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3