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Q9KRV2

- NAGK_VIBCH

UniProt

Q9KRV2 - NAGK_VIBCH

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Protein

N-acetyl-D-glucosamine kinase

Gene

nagK

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.UniRule annotation

Catalytic activityi

ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi157 – 1571ZincUniRule annotation
Metal bindingi177 – 1771ZincUniRule annotation
Metal bindingi179 – 1791ZincUniRule annotation
Metal bindingi184 – 1841ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi4 – 118ATPUniRule annotation
Nucleotide bindingi133 – 1408ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. N-acetylglucosamine kinase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. N-acetylglucosamine metabolic process Source: UniProtKB-HAMAP
  2. peptidoglycan turnover Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Carbohydrate metabolism

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

BioCyciVCHO:VC1532-MONOMER.
UniPathwayiUPA00544.

Names & Taxonomyi

Protein namesi
Recommended name:
N-acetyl-D-glucosamine kinaseUniRule annotation (EC:2.7.1.59UniRule annotation)
Alternative name(s):
GlcNAc kinaseUniRule annotation
Gene namesi
Name:nagKUniRule annotation
Ordered Locus Names:VC_1532
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 302302N-acetyl-D-glucosamine kinasePRO_0000270119Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243277.VC1532.

Structurei

3D structure databases

ProteinModelPortaliQ9KRV2.
SMRiQ9KRV2. Positions 1-301.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ROK (NagC/XylR) family. NagK subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1940.
KOiK00884.
OMAiPEIVAQW.
OrthoDBiEOG61P6P0.

Family and domain databases

HAMAPiMF_01271. GlcNAc_kinase.
InterProiIPR023505. N-acetyl-D-glucosamine_kinase.
IPR000600. ROK.
[Graphical view]
PfamiPF00480. ROK. 1 hit.
[Graphical view]
PROSITEiPS01125. ROK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KRV2-1 [UniParc]FASTAAdd to Basket

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        10         20         30         40         50
MYYGFDVGGT KIEFGAFNEQ LERVATERVA TPTDDYAKLV ETIAGLVHKY
60 70 80 90 100
DAQFGVEGTV GLGIPGMEDA DNGCVLTVNV PAAKGKPLRA DLETKLGRAV
110 120 130 140 150
KVENDANCFA LSEAWDDELK EAASVMGLIL GTGFGGGLVY EGKVFSGRNH
160 170 180 190 200
VAGEIGHMRL PIDAWFHLGE KAPLLGCGCG NKGCMDNYLS GRGFELLYEH
210 220 230 240 250
YYGEKKKAID IITAQKEGES KAVEHVERFM ELLAICFANI FTANDPHVVV
260 270 280 290 300
LGGGLSNYDL IYEEMPKRVP KHLLSVAKCP KIVKAKHGDS GGVRGAAFLN

IK
Length:302
Mass (Da):32,603
Last modified:October 1, 2000 - v1
Checksum:i5B21F13445425464
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003852 Genomic DNA. Translation: AAF94686.1.
PIRiB82189.
RefSeqiNP_231172.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF94686; AAF94686; VC_1532.
GeneIDi2613911.
KEGGivch:VC1532.
PATRICi20082123. VBIVibCho83274_1460.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003852 Genomic DNA. Translation: AAF94686.1 .
PIRi B82189.
RefSeqi NP_231172.1. NC_002505.1.

3D structure databases

ProteinModelPortali Q9KRV2.
SMRi Q9KRV2. Positions 1-301.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243277.VC1532.

Protocols and materials databases

DNASUi 2613911.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF94686 ; AAF94686 ; VC_1532 .
GeneIDi 2613911.
KEGGi vch:VC1532.
PATRICi 20082123. VBIVibCho83274_1460.

Phylogenomic databases

eggNOGi COG1940.
KOi K00884.
OMAi PEIVAQW.
OrthoDBi EOG61P6P0.

Enzyme and pathway databases

UniPathwayi UPA00544 .
BioCyci VCHO:VC1532-MONOMER.

Family and domain databases

HAMAPi MF_01271. GlcNAc_kinase.
InterProi IPR023505. N-acetyl-D-glucosamine_kinase.
IPR000600. ROK.
[Graphical view ]
Pfami PF00480. ROK. 1 hit.
[Graphical view ]
PROSITEi PS01125. ROK. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.

Entry informationi

Entry nameiNAGK_VIBCH
AccessioniPrimary (citable) accession number: Q9KRV2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: October 1, 2000
Last modified: October 1, 2014
This is version 68 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3