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Q9KRV2

- NAGK_VIBCH

UniProt

Q9KRV2 - NAGK_VIBCH

Protein

N-acetyl-D-glucosamine kinase

Gene

nagK

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 68 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of N-acetyl-D-glucosamine (GlcNAc) derived from cell-wall degradation, yielding GlcNAc-6-P.UniRule annotation

    Catalytic activityi

    ATP + N-acetyl-D-glucosamine = ADP + N-acetyl-D-glucosamine 6-phosphate.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi157 – 1571ZincUniRule annotation
    Metal bindingi177 – 1771ZincUniRule annotation
    Metal bindingi179 – 1791ZincUniRule annotation
    Metal bindingi184 – 1841ZincUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi4 – 118ATPUniRule annotation
    Nucleotide bindingi133 – 1408ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. N-acetylglucosamine kinase activity Source: UniProtKB-HAMAP
    3. zinc ion binding Source: UniProtKB-HAMAP

    GO - Biological processi

    1. N-acetylglucosamine metabolic process Source: UniProtKB-HAMAP
    2. peptidoglycan turnover Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Transferase

    Keywords - Biological processi

    Carbohydrate metabolism

    Keywords - Ligandi

    ATP-binding, Metal-binding, Nucleotide-binding, Zinc

    Enzyme and pathway databases

    BioCyciVCHO:VC1532-MONOMER.
    UniPathwayiUPA00544.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    N-acetyl-D-glucosamine kinaseUniRule annotation (EC:2.7.1.59UniRule annotation)
    Alternative name(s):
    GlcNAc kinaseUniRule annotation
    Gene namesi
    Name:nagKUniRule annotation
    Ordered Locus Names:VC_1532
    OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
    Taxonomic identifieri243277 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000000584: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 302302N-acetyl-D-glucosamine kinasePRO_0000270119Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243277.VC1532.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9KRV2.
    SMRiQ9KRV2. Positions 1-301.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ROK (NagC/XylR) family. NagK subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1940.
    KOiK00884.
    OMAiPEIVAQW.
    OrthoDBiEOG61P6P0.

    Family and domain databases

    HAMAPiMF_01271. GlcNAc_kinase.
    InterProiIPR023505. N-acetyl-D-glucosamine_kinase.
    IPR000600. ROK.
    [Graphical view]
    PfamiPF00480. ROK. 1 hit.
    [Graphical view]
    PROSITEiPS01125. ROK. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9KRV2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MYYGFDVGGT KIEFGAFNEQ LERVATERVA TPTDDYAKLV ETIAGLVHKY    50
    DAQFGVEGTV GLGIPGMEDA DNGCVLTVNV PAAKGKPLRA DLETKLGRAV 100
    KVENDANCFA LSEAWDDELK EAASVMGLIL GTGFGGGLVY EGKVFSGRNH 150
    VAGEIGHMRL PIDAWFHLGE KAPLLGCGCG NKGCMDNYLS GRGFELLYEH 200
    YYGEKKKAID IITAQKEGES KAVEHVERFM ELLAICFANI FTANDPHVVV 250
    LGGGLSNYDL IYEEMPKRVP KHLLSVAKCP KIVKAKHGDS GGVRGAAFLN 300
    IK 302
    Length:302
    Mass (Da):32,603
    Last modified:October 1, 2000 - v1
    Checksum:i5B21F13445425464
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE003852 Genomic DNA. Translation: AAF94686.1.
    PIRiB82189.
    RefSeqiNP_231172.1. NC_002505.1.

    Genome annotation databases

    EnsemblBacteriaiAAF94686; AAF94686; VC_1532.
    GeneIDi2613911.
    KEGGivch:VC1532.
    PATRICi20082123. VBIVibCho83274_1460.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE003852 Genomic DNA. Translation: AAF94686.1 .
    PIRi B82189.
    RefSeqi NP_231172.1. NC_002505.1.

    3D structure databases

    ProteinModelPortali Q9KRV2.
    SMRi Q9KRV2. Positions 1-301.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243277.VC1532.

    Protocols and materials databases

    DNASUi 2613911.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF94686 ; AAF94686 ; VC_1532 .
    GeneIDi 2613911.
    KEGGi vch:VC1532.
    PATRICi 20082123. VBIVibCho83274_1460.

    Phylogenomic databases

    eggNOGi COG1940.
    KOi K00884.
    OMAi PEIVAQW.
    OrthoDBi EOG61P6P0.

    Enzyme and pathway databases

    UniPathwayi UPA00544 .
    BioCyci VCHO:VC1532-MONOMER.

    Family and domain databases

    HAMAPi MF_01271. GlcNAc_kinase.
    InterProi IPR023505. N-acetyl-D-glucosamine_kinase.
    IPR000600. ROK.
    [Graphical view ]
    Pfami PF00480. ROK. 1 hit.
    [Graphical view ]
    PROSITEi PS01125. ROK. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39315 / El Tor Inaba N16961.

    Entry informationi

    Entry nameiNAGK_VIBCH
    AccessioniPrimary (citable) accession number: Q9KRV2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 9, 2007
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 68 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3