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Q9KRA7

- LFTR_VIBCH

UniProt

Q9KRA7 - LFTR_VIBCH

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Protein

Leucyl/phenylalanyl-tRNA--protein transferase

Gene

aat

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine.UniRule annotation

Catalytic activityi

L-leucyl-tRNA(Leu) + [protein] = tRNA(Leu) + L-leucyl-[protein].UniRule annotation
L-phenylalanyl-tRNA(Phe) + [protein] = tRNA + L-phenylalanyl-[protein].UniRule annotation

GO - Molecular functioni

  1. leucyltransferase activity Source: UniProtKB-EC
  2. peptidase activity Source: TIGR

GO - Biological processi

  1. protein catabolic process Source: InterPro
  2. proteolysis Source: TIGR
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciVCHO:VC1735-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucyl/phenylalanyl-tRNA--protein transferaseUniRule annotation (EC:2.3.2.6UniRule annotation)
Alternative name(s):
L/F-transferaseUniRule annotation
LeucyltransferaseUniRule annotation
PhenyalanyltransferaseUniRule annotation
Gene namesi
Name:aatUniRule annotation
Ordered Locus Names:VC_1735
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584: Chromosome 1

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 243243Leucyl/phenylalanyl-tRNA--protein transferasePRO_0000207247Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243277.VC1735.

Structurei

3D structure databases

ProteinModelPortaliQ9KRA7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the L/F-transferase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2360.
KOiK00684.
OMAiWSPDPRG.
OrthoDBiEOG6WX4R3.

Family and domain databases

HAMAPiMF_00688. Leu_Phe_trans.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR004616. Leu/Phe-tRNA_Trfase.
[Graphical view]
PfamiPF03588. Leu_Phe_trans. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR00667. aat. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9KRA7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAIYLTELSP ETLTFPSPFT ALDDPNGLLA FGGDLRLERI WAAYQQGIFP
60 70 80 90 100
WYGPEDPILW WSPSPRAVFD PTRFQPAKSV KKFQRKHQYR VSVNHATSQV
110 120 130 140 150
IEQCALTRPA DQRWLNDSMR HAYGELAKQG RCHSVEVWQG EQLVGGLYGI
160 170 180 190 200
SVGQLFCGES MFSLATNASK IALWYFCDHF SRHQGQLIDC QVMNPHLQSL
210 220 230 240
GATTLSREQF IQSLLSFKEK QVLSGCFETQ WLATPTSPCA FED
Length:243
Mass (Da):27,569
Last modified:October 1, 2000 - v1
Checksum:i24AF885AE888D515
GO

Sequence cautioni

The sequence AAB87633.1 differs from that shown. Reason: Frameshift at position 206. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF94885.1.
AF035002 Genomic DNA. Translation: AAB87633.1. Frameshift.
PIRiG82163.
RefSeqiNP_231371.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF94885; AAF94885; VC_1735.
GeneIDi2613740.
KEGGivch:VC1735.
PATRICi20082524. VBIVibCho83274_1658.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF94885.1 .
AF035002 Genomic DNA. Translation: AAB87633.1 . Frameshift.
PIRi G82163.
RefSeqi NP_231371.1. NC_002505.1.

3D structure databases

ProteinModelPortali Q9KRA7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243277.VC1735.

Protocols and materials databases

DNASUi 2613740.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF94885 ; AAF94885 ; VC_1735 .
GeneIDi 2613740.
KEGGi vch:VC1735.
PATRICi 20082524. VBIVibCho83274_1658.

Phylogenomic databases

eggNOGi COG2360.
KOi K00684.
OMAi WSPDPRG.
OrthoDBi EOG6WX4R3.

Enzyme and pathway databases

BioCyci VCHO:VC1735-MONOMER.

Family and domain databases

HAMAPi MF_00688. Leu_Phe_trans.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR004616. Leu/Phe-tRNA_Trfase.
[Graphical view ]
Pfami PF03588. Leu_Phe_trans. 1 hit.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 1 hit.
TIGRFAMsi TIGR00667. aat. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.
  2. "Substrate recognition by the leucyl/phenylalanyl-tRNA-protein transferase. Conservation within the enzyme family and localization to the trypsin-resistant domain."
    Ichetovkin I.E., Abramochkin G., Shrader T.E.
    J. Biol. Chem. 272:33009-33014(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-208.

Entry informationi

Entry nameiLFTR_VIBCH
AccessioniPrimary (citable) accession number: Q9KRA7
Secondary accession number(s): O50259
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: October 1, 2000
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3