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Q9KRA7

- LFTR_VIBCH

UniProt

Q9KRA7 - LFTR_VIBCH

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Protein
Leucyl/phenylalanyl-tRNA--protein transferase
Gene
aat, VC_1735
Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Functions in the N-end rule pathway of protein degradation where it conjugates Leu, Phe and, less efficiently, Met from aminoacyl-tRNAs to the N-termini of proteins containing an N-terminal arginine or lysine By similarity.UniRule annotation

Catalytic activityi

L-leucyl-tRNA(Leu) + [protein] = tRNA(Leu) + L-leucyl-[protein].UniRule annotation
L-phenylalanyl-tRNA(Phe) + [protein] = tRNA + L-phenylalanyl-[protein].UniRule annotation

GO - Molecular functioni

  1. leucyltransferase activity Source: UniProtKB-EC
  2. peptidase activity Source: TIGR

GO - Biological processi

  1. protein catabolic process Source: InterPro
  2. proteolysis Source: TIGR
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Enzyme and pathway databases

BioCyciVCHO:VC1735-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucyl/phenylalanyl-tRNA--protein transferase (EC:2.3.2.6)
Alternative name(s):
L/F-transferase
Leucyltransferase
Phenyalanyltransferase
Gene namesi
Name:aat
Ordered Locus Names:VC_1735
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584: Chromosome 1

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 243243Leucyl/phenylalanyl-tRNA--protein transferaseUniRule annotation
PRO_0000207247Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243277.VC1735.

Structurei

3D structure databases

ProteinModelPortaliQ9KRA7.

Family & Domainsi

Sequence similaritiesi

Belongs to the L/F-transferase family.

Phylogenomic databases

eggNOGiCOG2360.
KOiK00684.
OMAiWSPDPRG.
OrthoDBiEOG6WX4R3.

Family and domain databases

HAMAPiMF_00688. Leu_Phe_trans.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR004616. Leu/Phe-tRNA_Trfase.
[Graphical view]
PfamiPF03588. Leu_Phe_trans. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR00667. aat. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9KRA7-1 [UniParc]FASTAAdd to Basket

« Hide

MAIYLTELSP ETLTFPSPFT ALDDPNGLLA FGGDLRLERI WAAYQQGIFP    50
WYGPEDPILW WSPSPRAVFD PTRFQPAKSV KKFQRKHQYR VSVNHATSQV 100
IEQCALTRPA DQRWLNDSMR HAYGELAKQG RCHSVEVWQG EQLVGGLYGI 150
SVGQLFCGES MFSLATNASK IALWYFCDHF SRHQGQLIDC QVMNPHLQSL 200
GATTLSREQF IQSLLSFKEK QVLSGCFETQ WLATPTSPCA FED 243
Length:243
Mass (Da):27,569
Last modified:October 1, 2000 - v1
Checksum:i24AF885AE888D515
GO

Sequence cautioni

The sequence AAB87633.1 differs from that shown. Reason: Frameshift at position 206.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003852 Genomic DNA. Translation: AAF94885.1.
AF035002 Genomic DNA. Translation: AAB87633.1. Frameshift.
PIRiG82163.
RefSeqiNP_231371.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF94885; AAF94885; VC_1735.
GeneIDi2613740.
KEGGivch:VC1735.
PATRICi20082524. VBIVibCho83274_1658.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003852 Genomic DNA. Translation: AAF94885.1 .
AF035002 Genomic DNA. Translation: AAB87633.1 . Frameshift.
PIRi G82163.
RefSeqi NP_231371.1. NC_002505.1.

3D structure databases

ProteinModelPortali Q9KRA7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243277.VC1735.

Protocols and materials databases

DNASUi 2613740.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF94885 ; AAF94885 ; VC_1735 .
GeneIDi 2613740.
KEGGi vch:VC1735.
PATRICi 20082524. VBIVibCho83274_1658.

Phylogenomic databases

eggNOGi COG2360.
KOi K00684.
OMAi WSPDPRG.
OrthoDBi EOG6WX4R3.

Enzyme and pathway databases

BioCyci VCHO:VC1735-MONOMER.

Family and domain databases

HAMAPi MF_00688. Leu_Phe_trans.
InterProi IPR016181. Acyl_CoA_acyltransferase.
IPR004616. Leu/Phe-tRNA_Trfase.
[Graphical view ]
Pfami PF03588. Leu_Phe_trans. 1 hit.
[Graphical view ]
SUPFAMi SSF55729. SSF55729. 1 hit.
TIGRFAMsi TIGR00667. aat. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.
  2. "Substrate recognition by the leucyl/phenylalanyl-tRNA-protein transferase. Conservation within the enzyme family and localization to the trypsin-resistant domain."
    Ichetovkin I.E., Abramochkin G., Shrader T.E.
    J. Biol. Chem. 272:33009-33014(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-208.

Entry informationi

Entry nameiLFTR_VIBCH
AccessioniPrimary (citable) accession number: Q9KRA7
Secondary accession number(s): O50259
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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