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Protein
Submitted name:

L-asparaginase I

Gene

VC_1995

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei14 – 141O-isoaspartyl threonine intermediateUniRule annotation
Binding sitei60 – 601SubstrateUniRule annotation

GO - Molecular functioni

  • asparaginase activity Source: TIGR

GO - Biological processi

  • cellular amino acid metabolic process Source: TIGR
Complete GO annotation...

Enzyme and pathway databases

BioCyciVCHO:VC1995-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
L-asparaginase IImported
Gene namesi
Ordered Locus Names:VC_1995Imported
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)Imported
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000000584 Componenti: Chromosome 1

Interactioni

Protein-protein interaction databases

STRINGi243277.VC1995.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2OCDX-ray2.45A/B/C/D1-337[»]
ProteinModelPortaliQ9KQK3.
SMRiQ9KQK3. Positions 2-337.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9KQK3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini5 – 192188AsparaginaseInterPro annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni91 – 922Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the asparaginase 1 family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105HDK. Bacteria.
COG0252. LUCA.
KOiK01424.
OMAiMPEFYHD.
OrthoDBiEOG683S61.

Family and domain databases

Gene3Di3.40.50.1170. 1 hit.
3.40.50.40. 1 hit.
InterProiIPR006033. AsnASEI.
IPR006034. Asparaginase/glutaminase.
IPR020827. Asparaginase/glutaminase_AS1.
IPR027475. Asparaginase/glutaminase_AS2.
IPR027473. L-asparaginase_C.
IPR027474. L-asparaginase_N.
[Graphical view]
PfamiPF00710. Asparaginase. 1 hit.
[Graphical view]
PIRSFiPIRSF001220. L-ASNase_gatD. 1 hit.
PRINTSiPR00139. ASNGLNASE.
SMARTiSM00870. Asparaginase. 1 hit.
[Graphical view]
SUPFAMiSSF53774. SSF53774. 1 hit.
TIGRFAMsiTIGR00519. asnASE_I. 1 hit.
PROSITEiPS00144. ASN_GLN_ASE_1. 1 hit.
PS00917. ASN_GLN_ASE_2. 1 hit.
PS51732. ASN_GLN_ASE_3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KQK3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARKHIYIAY TGGTIGMKKS DHGYVPVAGF MEKQLASMPE FHRPEMPLFT
60 70 80 90 100
IHEYDPLMDS SDMTPADWQL IADDIAANYD KYDGFVILHG TDTMAYTASA
110 120 130 140 150
LSFMFENLGK PVIVTGSQIP LADLRSDGQA NLLNALHVAA NYPINEVTLF
160 170 180 190 200
FNNRLMRGNR SRKSHADGFS AFSSPNLPPL LEAGINIELS TNVKVDEKPS
210 220 230 240 250
GEFKVNPITP QPIGVITMYP GISHEVIRNT LLQPVNAMIL LTFGVGNAPQ
260 270 280 290 300
NPELLAQLKA ASERGVIVVN LTQCLAGKVN MGGYATGCAL ADAGVISGYD
310 320 330
MTPEAALAKL HYLLSQNLSY EEVKAKMQQV LRGEMTL
Length:337
Mass (Da):36,707
Last modified:October 1, 2000 - v1
Checksum:iCC7489AA6F136840
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF95143.1.
PIRiA82131.
RefSeqiNP_231629.1. NC_002505.1.
WP_000101384.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF95143; AAF95143; VC_1995.
GeneIDi2613499.
KEGGivch:VC1995.
PATRICi20083024. VBIVibCho83274_1906.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF95143.1.
PIRiA82131.
RefSeqiNP_231629.1. NC_002505.1.
WP_000101384.1. NC_002505.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2OCDX-ray2.45A/B/C/D1-337[»]
ProteinModelPortaliQ9KQK3.
SMRiQ9KQK3. Positions 2-337.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243277.VC1995.

Protocols and materials databases

DNASUi2613499.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF95143; AAF95143; VC_1995.
GeneIDi2613499.
KEGGivch:VC1995.
PATRICi20083024. VBIVibCho83274_1906.

Phylogenomic databases

eggNOGiENOG4105HDK. Bacteria.
COG0252. LUCA.
KOiK01424.
OMAiMPEFYHD.
OrthoDBiEOG683S61.

Enzyme and pathway databases

BioCyciVCHO:VC1995-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9KQK3.

Family and domain databases

Gene3Di3.40.50.1170. 1 hit.
3.40.50.40. 1 hit.
InterProiIPR006033. AsnASEI.
IPR006034. Asparaginase/glutaminase.
IPR020827. Asparaginase/glutaminase_AS1.
IPR027475. Asparaginase/glutaminase_AS2.
IPR027473. L-asparaginase_C.
IPR027474. L-asparaginase_N.
[Graphical view]
PfamiPF00710. Asparaginase. 1 hit.
[Graphical view]
PIRSFiPIRSF001220. L-ASNase_gatD. 1 hit.
PRINTSiPR00139. ASNGLNASE.
SMARTiSM00870. Asparaginase. 1 hit.
[Graphical view]
SUPFAMiSSF53774. SSF53774. 1 hit.
TIGRFAMsiTIGR00519. asnASE_I. 1 hit.
PROSITEiPS00144. ASN_GLN_ASE_1. 1 hit.
PS00917. ASN_GLN_ASE_2. 1 hit.
PS51732. ASN_GLN_ASE_3. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961Imported.
  2. "Crystal structure of L-asparaginase I from Vibrio cholerae O1 biovar eltor str. N16961."
    Nocek B., Wu R., Moy S., Joachimiak A.
    Submitted (DEC-2006) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.45 ANGSTROMS).

Entry informationi

Entry nameiQ9KQK3_VIBCH
AccessioniPrimary (citable) accession number: Q9KQK3
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2000
Last sequence update: October 1, 2000
Last modified: May 11, 2016
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.