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Protein

Thymidylate kinase

Gene

tmk

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis.By similarity

Catalytic activityi

ATP + dTMP = ADP + dTDP.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 17ATPSequence analysis8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-HAMAP
  • thymidylate kinase activity Source: TIGR
  • uridylate kinase activity Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Biological processi

Nucleotide biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVCHO:VC2016-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidylate kinase (EC:2.7.4.9)
Alternative name(s):
dTMP kinase
Gene namesi
Name:tmk
Ordered Locus Names:VC_2016
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000000584 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001553671 – 212Thymidylate kinaseAdd BLAST212

Interactioni

Protein-protein interaction databases

STRINGi243277.VC2016.

Structurei

Secondary structure

1212
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi5 – 11Combined sources7
Helixi16 – 29Combined sources14
Beta strandi35 – 41Combined sources7
Helixi45 – 55Combined sources11
Helixi65 – 82Combined sources18
Helixi84 – 89Combined sources6
Beta strandi93 – 98Combined sources6
Helixi100 – 106Combined sources7
Turni107 – 111Combined sources5
Helixi115 – 126Combined sources12
Beta strandi132 – 138Combined sources7
Helixi141 – 146Combined sources6
Turni156 – 159Combined sources4
Helixi162 – 178Combined sources17
Beta strandi182 – 186Combined sources5
Helixi191 – 206Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LV8X-ray1.80A1-212[»]
3N2IX-ray2.25A/B1-212[»]
ProteinModelPortaliQ9KQI2.
SMRiQ9KQI2.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9KQI2.

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidylate kinase family.Curated

Phylogenomic databases

eggNOGiENOG4108ZMD. Bacteria.
COG0125. LUCA.
KOiK00943.
OMAiGGIDIAE.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KQI2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAKFIVIEG LEGAGKSTAI QVVVETLQQN GIDHITRTRE PGGTLLAEKL
60 70 80 90 100
RALVKEEHPG EELQDITELL LVYAARVQLV ENVIKPALAR GEWVVGDRHD
110 120 130 140 150
MSSQAYQGGG RQIAPSTMQS LKQTALGDFK PDLTLYLDID PKLGLERARG
160 170 180 190 200
RGELDRIEKM DISFFERARE RYLELANSDD SVVMIDAAQS IEQVTADIRR
210
ALQDWLSQVN RV
Length:212
Mass (Da):23,666
Last modified:October 1, 2000 - v1
Checksum:i8F4F51A00CE60F4D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF95164.1.
PIRiA82128.
RefSeqiNP_231650.1. NC_002505.1.
WP_000991933.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF95164; AAF95164; VC_2016.
GeneIDi2613395.
KEGGivch:VC2016.
PATRICi20083064. VBIVibCho83274_1926.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF95164.1.
PIRiA82128.
RefSeqiNP_231650.1. NC_002505.1.
WP_000991933.1. NC_002505.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3LV8X-ray1.80A1-212[»]
3N2IX-ray2.25A/B1-212[»]
ProteinModelPortaliQ9KQI2.
SMRiQ9KQI2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243277.VC2016.

Protocols and materials databases

DNASUi2613395.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF95164; AAF95164; VC_2016.
GeneIDi2613395.
KEGGivch:VC2016.
PATRICi20083064. VBIVibCho83274_1926.

Phylogenomic databases

eggNOGiENOG4108ZMD. Bacteria.
COG0125. LUCA.
KOiK00943.
OMAiGGIDIAE.

Enzyme and pathway databases

BioCyciVCHO:VC2016-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9KQI2.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00165. Thymidylate_kinase. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR018095. Thymidylate_kin_CS.
IPR018094. Thymidylate_kinase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
TIGRFAMsiTIGR00041. DTMP_kinase. 1 hit.
PROSITEiPS01331. THYMIDYLATE_KINASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKTHY_VIBCH
AccessioniPrimary (citable) accession number: Q9KQI2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: October 1, 2000
Last modified: November 2, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.