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Q9KQH9

- FABF_VIBCH

UniProt

Q9KQH9 - FABF_VIBCH

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Protein

3-oxoacyl-[acyl-carrier-protein] synthase 2

Gene

fabF

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthesis (By similarity).By similarity

Catalytic activityi

(Z)-hexadec-11-enoyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = (Z)-3-oxooctadec-13-enoyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei164 – 1641PROSITE-ProRule annotation

GO - Molecular functioni

  1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: TIGR
  2. beta-ketoacyl-acyl-carrier-protein synthase II activity Source: UniProtKB-EC

GO - Biological processi

  1. fatty acid biosynthetic process Source: TIGR
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Enzyme and pathway databases

BioCyciVCHO:VC2019-MONOMER.
UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 2 (EC:2.3.1.179)
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase II
Beta-ketoacyl-ACP synthase II
Short name:
KAS II
Gene namesi
Name:fabF
Ordered Locus Names:VC_2019
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 4144133-oxoacyl-[acyl-carrier-protein] synthase 2PRO_0000180327Add
BLAST

Proteomic databases

PRIDEiQ9KQH9.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi243277.VC2019.

Structurei

Secondary structure

1
414
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi6 – 1510
Beta strandi18 – 203
Helixi21 – 299
Beta strandi35 – 373
Beta strandi50 – 523
Helixi59 – 613
Helixi65 – 684
Helixi73 – 8917
Turni95 – 973
Helixi98 – 1003
Beta strandi101 – 1066
Helixi112 – 12514
Helixi127 – 1293
Helixi134 – 1385
Helixi142 – 15110
Helixi163 – 1653
Helixi166 – 18015
Beta strandi184 – 1929
Helixi197 – 2059
Helixi216 – 2194
Beta strandi235 – 2439
Helixi244 – 2496
Beta strandi256 – 26510
Beta strandi270 – 2723
Helixi278 – 29114
Helixi295 – 2973
Beta strandi298 – 3025
Helixi309 – 33022
Beta strandi332 – 3343
Helixi337 – 3404
Helixi344 – 3463
Helixi347 – 36115
Beta strandi371 – 3733
Beta strandi383 – 3853
Beta strandi394 – 4018
Turni402 – 4043
Beta strandi405 – 4139

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4JRHX-ray2.20A/B1-414[»]
4JRMX-ray1.75A/B/C/D1-414[»]
ProteinModelPortaliQ9KQH9.
SMRiQ9KQH9. Positions 3-414.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the beta-ketoacyl-ACP synthases family.Curated

Phylogenomic databases

eggNOGiCOG0304.
KOiK09458.
OMAiCMANALR.
OrthoDBiEOG6DG2SR.

Family and domain databases

Gene3Di3.40.47.10. 2 hits.
InterProiIPR017568. 3-oxoacyl-ACP_synth-2.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamiPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000447. KAS_II. 1 hit.
SUPFAMiSSF53901. SSF53901. 2 hits.
TIGRFAMsiTIGR03150. fabF. 1 hit.
PROSITEiPS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9KQH9 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSKRRVVVTG MGMLSPVGNT VESSWKALLA GQSGIVNIEH FDTTNFSTRF
60 70 80 90 100
AGLVKGFDCE QYMSKKDARK MDLFIQYGIA AGIQALEDSG LEVNEENAAR
110 120 130 140 150
IGVAIGSGIG GLELIETGHQ ALIEKGPRKV SPFFVPSTIV NMIAGNLSIM
160 170 180 190 200
RGLRGPNIAI STACTTGLHN IGHAARMIAY GDADAMVAGG AEKASTPLGM
210 220 230 240 250
AGFGAAKALS TRNDEPQKAS RPWDKDRDGF VLGDGAGIMV LEEYEHAKAR
260 270 280 290 300
GAKIYAEVVG FGMSGDAYHM TSPSEDGSGG ALAMEAAMRD AGVTGEQIGY
310 320 330 340 350
VNAHGTSTPA GDVAEVKGIK RALGEAGTKQ VLVSSTKSMT GHLLGAAGSV
360 370 380 390 400
EAIITVMSLV DQMVPPTINL DNPEEGLGVD LVPHVARKVE SMEYAMCNSF
410
GFGGTNGSLI FKRM
Length:414
Mass (Da):43,208
Last modified:January 23, 2007 - v3
Checksum:iEB5942D01274ED1F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003852 Genomic DNA. Translation: AAF95167.1.
PIRiD82128.
RefSeqiNP_231653.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF95167; AAF95167; VC_2019.
GeneIDi2613398.
KEGGivch:VC2019.
PATRICi20083070. VBIVibCho83274_1929.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003852 Genomic DNA. Translation: AAF95167.1 .
PIRi D82128.
RefSeqi NP_231653.1. NC_002505.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4JRH X-ray 2.20 A/B 1-414 [» ]
4JRM X-ray 1.75 A/B/C/D 1-414 [» ]
ProteinModelPortali Q9KQH9.
SMRi Q9KQH9. Positions 3-414.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243277.VC2019.

Proteomic databases

PRIDEi Q9KQH9.

Protocols and materials databases

DNASUi 2613398.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF95167 ; AAF95167 ; VC_2019 .
GeneIDi 2613398.
KEGGi vch:VC2019.
PATRICi 20083070. VBIVibCho83274_1929.

Phylogenomic databases

eggNOGi COG0304.
KOi K09458.
OMAi CMANALR.
OrthoDBi EOG6DG2SR.

Enzyme and pathway databases

UniPathwayi UPA00094 .
BioCyci VCHO:VC2019-MONOMER.

Family and domain databases

Gene3Di 3.40.47.10. 2 hits.
InterProi IPR017568. 3-oxoacyl-ACP_synth-2.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view ]
Pfami PF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF000447. KAS_II. 1 hit.
SUPFAMi SSF53901. SSF53901. 2 hits.
TIGRFAMsi TIGR03150. fabF. 1 hit.
PROSITEi PS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.

Entry informationi

Entry nameiFABF_VIBCH
AccessioniPrimary (citable) accession number: Q9KQH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: January 23, 2007
Last modified: October 1, 2014
This is version 89 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3