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Q9KQH9 (FABF_VIBCH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 88. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] synthase 2

EC=2.3.1.179
Alternative name(s):
3-oxoacyl-[acyl-carrier-protein] synthase II
Beta-ketoacyl-ACP synthase II
Short name=KAS II
Gene names
Name:fabF
Ordered Locus Names:VC_2019
OrganismVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) [Reference proteome] [HAMAP]
Taxonomic identifier243277 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length414 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthesis By similarity.

Catalytic activity

(Z)-hexadec-11-enoyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = (Z)-3-oxooctadec-13-enoyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subunit structure

Homodimer By similarity.

Sequence similarities

Belongs to the beta-ketoacyl-ACP synthases family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 4144133-oxoacyl-[acyl-carrier-protein] synthase 2
PRO_0000180327

Sites

Active site1641 By similarity

Secondary structure

.................................................................. 414
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9KQH9 [UniParc].

Last modified January 23, 2007. Version 3.
Checksum: EB5942D01274ED1F

FASTA41443,208
        10         20         30         40         50         60 
MSKRRVVVTG MGMLSPVGNT VESSWKALLA GQSGIVNIEH FDTTNFSTRF AGLVKGFDCE 

        70         80         90        100        110        120 
QYMSKKDARK MDLFIQYGIA AGIQALEDSG LEVNEENAAR IGVAIGSGIG GLELIETGHQ 

       130        140        150        160        170        180 
ALIEKGPRKV SPFFVPSTIV NMIAGNLSIM RGLRGPNIAI STACTTGLHN IGHAARMIAY 

       190        200        210        220        230        240 
GDADAMVAGG AEKASTPLGM AGFGAAKALS TRNDEPQKAS RPWDKDRDGF VLGDGAGIMV 

       250        260        270        280        290        300 
LEEYEHAKAR GAKIYAEVVG FGMSGDAYHM TSPSEDGSGG ALAMEAAMRD AGVTGEQIGY 

       310        320        330        340        350        360 
VNAHGTSTPA GDVAEVKGIK RALGEAGTKQ VLVSSTKSMT GHLLGAAGSV EAIITVMSLV 

       370        380        390        400        410 
DQMVPPTINL DNPEEGLGVD LVPHVARKVE SMEYAMCNSF GFGGTNGSLI FKRM 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE003852 Genomic DNA. Translation: AAF95167.1.
PIRD82128.
RefSeqNP_231653.1. NC_002505.1.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4JRHX-ray2.20A/B1-414[»]
4JRMX-ray1.75A/B/C/D1-414[»]
ProteinModelPortalQ9KQH9.
SMRQ9KQH9. Positions 3-414.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243277.VC2019.

Proteomic databases

PRIDEQ9KQH9.

Protocols and materials databases

DNASU2613398.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF95167; AAF95167; VC_2019.
GeneID2613398.
KEGGvch:VC2019.
PATRIC20083070. VBIVibCho83274_1929.

Phylogenomic databases

eggNOGCOG0304.
KOK09458.
OMACMANALR.
OrthoDBEOG6DG2SR.

Enzyme and pathway databases

BioCycVCHO:VC2019-MONOMER.
UniPathwayUPA00094.

Family and domain databases

Gene3D3.40.47.10. 2 hits.
InterProIPR017568. 3-oxoacyl-ACP_synth-2.
IPR018201. Ketoacyl_synth_AS.
IPR014031. Ketoacyl_synth_C.
IPR014030. Ketoacyl_synth_N.
IPR016039. Thiolase-like.
IPR016038. Thiolase-like_subgr.
[Graphical view]
PfamPF00109. ketoacyl-synt. 1 hit.
PF02801. Ketoacyl-synt_C. 1 hit.
[Graphical view]
PIRSFPIRSF000447. KAS_II. 1 hit.
SUPFAMSSF53901. SSF53901. 2 hits.
TIGRFAMsTIGR03150. fabF. 1 hit.
PROSITEPS00606. B_KETOACYL_SYNTHASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFABF_VIBCH
AccessionPrimary (citable) accession number: Q9KQH9
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: January 23, 2007
Last modified: May 14, 2014
This is version 88 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways