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Q9KQH9

- FABF_VIBCH

UniProt

Q9KQH9 - FABF_VIBCH

Protein

3-oxoacyl-[acyl-carrier-protein] synthase 2

Gene

fabF

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates and may function to supply the octanoic substrates for lipoic acid biosynthesis By similarity.By similarity

    Catalytic activityi

    (Z)-hexadec-11-enoyl-[acyl-carrier-protein] + malonyl-[acyl-carrier-protein] = (Z)-3-oxooctadec-13-enoyl-[acyl-carrier-protein] + CO2 + [acyl-carrier-protein].

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei164 – 1641PROSITE-ProRule annotation

    GO - Molecular functioni

    1. 3-oxoacyl-[acyl-carrier-protein] synthase activity Source: TIGR
    2. beta-ketoacyl-acyl-carrier-protein synthase II activity Source: UniProtKB-EC

    GO - Biological processi

    1. fatty acid biosynthetic process Source: TIGR

    Keywords - Molecular functioni

    Acyltransferase, Transferase

    Keywords - Biological processi

    Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

    Enzyme and pathway databases

    BioCyciVCHO:VC2019-MONOMER.
    UniPathwayiUPA00094.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    3-oxoacyl-[acyl-carrier-protein] synthase 2 (EC:2.3.1.179)
    Alternative name(s):
    3-oxoacyl-[acyl-carrier-protein] synthase II
    Beta-ketoacyl-ACP synthase II
    Short name:
    KAS II
    Gene namesi
    Name:fabF
    Ordered Locus Names:VC_2019
    OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
    Taxonomic identifieri243277 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000000584: Chromosome 1

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 4144133-oxoacyl-[acyl-carrier-protein] synthase 2PRO_0000180327Add
    BLAST

    Proteomic databases

    PRIDEiQ9KQH9.

    Interactioni

    Subunit structurei

    Homodimer.By similarity

    Protein-protein interaction databases

    STRINGi243277.VC2019.

    Structurei

    Secondary structure

    1
    414
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi6 – 1510
    Beta strandi18 – 203
    Helixi21 – 299
    Beta strandi35 – 373
    Beta strandi50 – 523
    Helixi59 – 613
    Helixi65 – 684
    Helixi73 – 8917
    Turni95 – 973
    Helixi98 – 1003
    Beta strandi101 – 1066
    Helixi112 – 12514
    Helixi127 – 1293
    Helixi134 – 1385
    Helixi142 – 15110
    Helixi163 – 1653
    Helixi166 – 18015
    Beta strandi184 – 1929
    Helixi197 – 2059
    Helixi216 – 2194
    Beta strandi235 – 2439
    Helixi244 – 2496
    Beta strandi256 – 26510
    Beta strandi270 – 2723
    Helixi278 – 29114
    Helixi295 – 2973
    Beta strandi298 – 3025
    Helixi309 – 33022
    Beta strandi332 – 3343
    Helixi337 – 3404
    Helixi344 – 3463
    Helixi347 – 36115
    Beta strandi371 – 3733
    Beta strandi383 – 3853
    Beta strandi394 – 4018
    Turni402 – 4043
    Beta strandi405 – 4139

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4JRHX-ray2.20A/B1-414[»]
    4JRMX-ray1.75A/B/C/D1-414[»]
    ProteinModelPortaliQ9KQH9.
    SMRiQ9KQH9. Positions 3-414.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the beta-ketoacyl-ACP synthases family.Curated

    Phylogenomic databases

    eggNOGiCOG0304.
    KOiK09458.
    OMAiCMANALR.
    OrthoDBiEOG6DG2SR.

    Family and domain databases

    Gene3Di3.40.47.10. 2 hits.
    InterProiIPR017568. 3-oxoacyl-ACP_synth-2.
    IPR018201. Ketoacyl_synth_AS.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view]
    PfamiPF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000447. KAS_II. 1 hit.
    SUPFAMiSSF53901. SSF53901. 2 hits.
    TIGRFAMsiTIGR03150. fabF. 1 hit.
    PROSITEiPS00606. B_KETOACYL_SYNTHASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q9KQH9-1 [UniParc]FASTAAdd to Basket

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    MSKRRVVVTG MGMLSPVGNT VESSWKALLA GQSGIVNIEH FDTTNFSTRF    50
    AGLVKGFDCE QYMSKKDARK MDLFIQYGIA AGIQALEDSG LEVNEENAAR 100
    IGVAIGSGIG GLELIETGHQ ALIEKGPRKV SPFFVPSTIV NMIAGNLSIM 150
    RGLRGPNIAI STACTTGLHN IGHAARMIAY GDADAMVAGG AEKASTPLGM 200
    AGFGAAKALS TRNDEPQKAS RPWDKDRDGF VLGDGAGIMV LEEYEHAKAR 250
    GAKIYAEVVG FGMSGDAYHM TSPSEDGSGG ALAMEAAMRD AGVTGEQIGY 300
    VNAHGTSTPA GDVAEVKGIK RALGEAGTKQ VLVSSTKSMT GHLLGAAGSV 350
    EAIITVMSLV DQMVPPTINL DNPEEGLGVD LVPHVARKVE SMEYAMCNSF 400
    GFGGTNGSLI FKRM 414
    Length:414
    Mass (Da):43,208
    Last modified:January 23, 2007 - v3
    Checksum:iEB5942D01274ED1F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE003852 Genomic DNA. Translation: AAF95167.1.
    PIRiD82128.
    RefSeqiNP_231653.1. NC_002505.1.

    Genome annotation databases

    EnsemblBacteriaiAAF95167; AAF95167; VC_2019.
    GeneIDi2613398.
    KEGGivch:VC2019.
    PATRICi20083070. VBIVibCho83274_1929.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE003852 Genomic DNA. Translation: AAF95167.1 .
    PIRi D82128.
    RefSeqi NP_231653.1. NC_002505.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4JRH X-ray 2.20 A/B 1-414 [» ]
    4JRM X-ray 1.75 A/B/C/D 1-414 [» ]
    ProteinModelPortali Q9KQH9.
    SMRi Q9KQH9. Positions 3-414.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243277.VC2019.

    Proteomic databases

    PRIDEi Q9KQH9.

    Protocols and materials databases

    DNASUi 2613398.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF95167 ; AAF95167 ; VC_2019 .
    GeneIDi 2613398.
    KEGGi vch:VC2019.
    PATRICi 20083070. VBIVibCho83274_1929.

    Phylogenomic databases

    eggNOGi COG0304.
    KOi K09458.
    OMAi CMANALR.
    OrthoDBi EOG6DG2SR.

    Enzyme and pathway databases

    UniPathwayi UPA00094 .
    BioCyci VCHO:VC2019-MONOMER.

    Family and domain databases

    Gene3Di 3.40.47.10. 2 hits.
    InterProi IPR017568. 3-oxoacyl-ACP_synth-2.
    IPR018201. Ketoacyl_synth_AS.
    IPR014031. Ketoacyl_synth_C.
    IPR014030. Ketoacyl_synth_N.
    IPR016039. Thiolase-like.
    IPR016038. Thiolase-like_subgr.
    [Graphical view ]
    Pfami PF00109. ketoacyl-synt. 1 hit.
    PF02801. Ketoacyl-synt_C. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000447. KAS_II. 1 hit.
    SUPFAMi SSF53901. SSF53901. 2 hits.
    TIGRFAMsi TIGR03150. fabF. 1 hit.
    PROSITEi PS00606. B_KETOACYL_SYNTHASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39315 / El Tor Inaba N16961.

    Entry informationi

    Entry nameiFABF_VIBCH
    AccessioniPrimary (citable) accession number: Q9KQH9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 89 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3