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Q9KQH7 (FABG_VIBCH) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG

EC=1.1.1.100
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase
Gene names
Name:fabG
Ordered Locus Names:VC_2021
OrganismVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) [Reference proteome] [HAMAP]
Taxonomic identifier243277 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length244 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis By similarity.

Catalytic activity

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathway

Lipid metabolism; fatty acid biosynthesis.

Subunit structure

Homotetramer By similarity.

Sequence similarities

Belongs to the short-chain dehydrogenases/reductases (SDR) family.

Sequence caution

The sequence AAF95169.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2442443-oxoacyl-[acyl-carrier-protein] reductase FabG
PRO_0000054694

Regions

Nucleotide binding12 – 154NADP By similarity
Nucleotide binding59 – 602NADP By similarity
Nucleotide binding151 – 1555NADP By similarity

Sites

Active site1511Proton acceptor By similarity
Binding site371NADP By similarity
Binding site861NADP; via carbonyl oxygen By similarity
Binding site1381Substrate By similarity
Binding site1841NADP; via amide nitrogen and carbonyl oxygen By similarity

Secondary structure

........................................ 244
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9KQH7 [UniParc].

Last modified June 20, 2001. Version 2.
Checksum: 9FB2E8278D7CC3CE

FASTA24425,566
        10         20         30         40         50         60 
MNLEGKVALV TGASRGIGKA IAELLAERGA KVIGTATSES GAQAISDYLG DNGKGMALNV 

        70         80         90        100        110        120 
TNPESIEAVL KAITDEFGGV DILVNNAGIT RDNLLMRMKE EEWSDIMETN LTSIFRLSKA 

       130        140        150        160        170        180 
VLRGMMKKRQ GRIINVGSVV GTMGNAGQAN YAAAKAGVIG FTKSMAREVA SRGVTVNTVA 

       190        200        210        220        230        240 
PGFIETDMTK ALNDEQRTAT LAQVPAGRLG DPREIASAVA FLASPEAAYI TGETLHVNGG 


MYMI 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE003852 Genomic DNA. Translation: AAF95169.1. Different initiation.
PIRF82128.
RefSeqNP_231655.1. NC_002505.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3RROX-ray2.00A/B1-244[»]
3RSHX-ray1.95A/B1-244[»]
3U09X-ray1.75A/B1-244[»]
4I08X-ray2.06A/B1-244[»]
ProteinModelPortalQ9KQH7.
SMRQ9KQH7. Positions 2-244.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243277.VC2021.

Proteomic databases

PRIDEQ9KQH7.

Protocols and materials databases

DNASU2613400.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF95169; AAF95169; VC_2021.
GeneID2613400.
KEGGvch:VC2021.
PATRIC20083074. VBIVibCho83274_1931.

Phylogenomic databases

eggNOGCOG1028.
KOK00059.
OMATGQELHV.
OrthoDBEOG6N3CR8.
ProtClustDBPRK05557.

Enzyme and pathway databases

UniPathwayUPA00094.

Family and domain databases

Gene3D3.40.50.720. 1 hit.
InterProIPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamPF00106. adh_short. 1 hit.
[Graphical view]
PIRSFPIRSF000126. 11-beta-HSD1. 1 hit.
PRINTSPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsTIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEPS00061. ADH_SHORT. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFABG_VIBCH
AccessionPrimary (citable) accession number: Q9KQH7
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: April 16, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways