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Q9KQH7

- FABG_VIBCH

UniProt

Q9KQH7 - FABG_VIBCH

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Protein

3-oxoacyl-[acyl-carrier-protein] reductase FabG

Gene
fabG, VC_2021
Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at protein leveli

Functioni

Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis By similarity.

Catalytic activityi

(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP+ = 3-oxoacyl-[acyl-carrier-protein] + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei37 – 371NADP By similarity
Binding sitei86 – 861NADP; via carbonyl oxygen By similarity
Binding sitei138 – 1381Substrate By similarity
Active sitei151 – 1511Proton acceptor By similarity
Binding sitei184 – 1841NADP; via amide nitrogen and carbonyl oxygen By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 154NADP By similarity
Nucleotide bindingi59 – 602NADP By similarity
Nucleotide bindingi151 – 1555NADP By similarity

GO - Molecular functioni

  1. 3-oxoacyl-[acyl-carrier-protein] reductase (NADPH) activity Source: UniProtKB
  2. NAD binding Source: InterPro
  3. NADP binding Source: UniProtKB

GO - Biological processi

  1. fatty acid biosynthetic process Source: TIGR
  2. fatty acid elongation Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Fatty acid biosynthesis, Fatty acid metabolism, Lipid biosynthesis, Lipid metabolism

Keywords - Ligandi

NADP

Enzyme and pathway databases

UniPathwayiUPA00094.

Names & Taxonomyi

Protein namesi
Recommended name:
3-oxoacyl-[acyl-carrier-protein] reductase FabG (EC:1.1.1.100)
Alternative name(s):
3-ketoacyl-acyl carrier protein reductase
Beta-Ketoacyl-acyl carrier protein reductase
Beta-ketoacyl-ACP reductase
Gene namesi
Name:fabG
Ordered Locus Names:VC_2021
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2442443-oxoacyl-[acyl-carrier-protein] reductase FabGPRO_0000054694Add
BLAST

Proteomic databases

PRIDEiQ9KQH7.

Interactioni

Subunit structurei

Homotetramer By similarity.

Protein-protein interaction databases

STRINGi243277.VC2021.

Structurei

Secondary structure

1
244
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi7 – 126
Helixi16 – 2712
Beta strandi31 – 388
Helixi39 – 4911
Helixi50 – 523
Beta strandi53 – 575
Helixi63 – 7715
Beta strandi81 – 855
Helixi95 – 973
Helixi100 – 11011
Helixi112 – 12817
Beta strandi131 – 1366
Helixi140 – 1434
Helixi149 – 16921
Helixi170 – 1723
Beta strandi174 – 1818
Beta strandi183 – 1864
Helixi187 – 1904
Helixi194 – 2018
Helixi212 – 22312
Helixi225 – 2273
Beta strandi234 – 2385

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3RROX-ray2.00A/B1-244[»]
3RSHX-ray1.95A/B1-244[»]
3U09X-ray1.75A/B1-244[»]
4I08X-ray2.06A/B1-244[»]
ProteinModelPortaliQ9KQH7.
SMRiQ9KQH7. Positions 2-244.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1028.
KOiK00059.
OMAiDEFGAID.
OrthoDBiEOG6N3CR8.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
InterProiIPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view]
PfamiPF00106. adh_short. 1 hit.
[Graphical view]
PIRSFiPIRSF000126. 11-beta-HSD1. 1 hit.
PRINTSiPR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsiTIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEiPS00061. ADH_SHORT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KQH7-1 [UniParc]FASTAAdd to Basket

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MNLEGKVALV TGASRGIGKA IAELLAERGA KVIGTATSES GAQAISDYLG    50
DNGKGMALNV TNPESIEAVL KAITDEFGGV DILVNNAGIT RDNLLMRMKE 100
EEWSDIMETN LTSIFRLSKA VLRGMMKKRQ GRIINVGSVV GTMGNAGQAN 150
YAAAKAGVIG FTKSMAREVA SRGVTVNTVA PGFIETDMTK ALNDEQRTAT 200
LAQVPAGRLG DPREIASAVA FLASPEAAYI TGETLHVNGG MYMI 244
Length:244
Mass (Da):25,566
Last modified:June 20, 2001 - v2
Checksum:i9FB2E8278D7CC3CE
GO

Sequence cautioni

The sequence AAF95169.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003852 Genomic DNA. Translation: AAF95169.1. Different initiation.
PIRiF82128.
RefSeqiNP_231655.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF95169; AAF95169; VC_2021.
GeneIDi2613400.
KEGGivch:VC2021.
PATRICi20083074. VBIVibCho83274_1931.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003852 Genomic DNA. Translation: AAF95169.1 . Different initiation.
PIRi F82128.
RefSeqi NP_231655.1. NC_002505.1.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
3RRO X-ray 2.00 A/B 1-244 [» ]
3RSH X-ray 1.95 A/B 1-244 [» ]
3U09 X-ray 1.75 A/B 1-244 [» ]
4I08 X-ray 2.06 A/B 1-244 [» ]
ProteinModelPortali Q9KQH7.
SMRi Q9KQH7. Positions 2-244.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243277.VC2021.

Proteomic databases

PRIDEi Q9KQH7.

Protocols and materials databases

DNASUi 2613400.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF95169 ; AAF95169 ; VC_2021 .
GeneIDi 2613400.
KEGGi vch:VC2021.
PATRICi 20083074. VBIVibCho83274_1931.

Phylogenomic databases

eggNOGi COG1028.
KOi K00059.
OMAi DEFGAID.
OrthoDBi EOG6N3CR8.

Enzyme and pathway databases

UniPathwayi UPA00094 .

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
InterProi IPR011284. 3oxo_ACP_reduc.
IPR002198. DH_sc/Rdtase_SDR.
IPR002347. Glc/ribitol_DH.
IPR016040. NAD(P)-bd_dom.
IPR020904. Sc_DH/Rdtase_CS.
[Graphical view ]
Pfami PF00106. adh_short. 1 hit.
[Graphical view ]
PIRSFi PIRSF000126. 11-beta-HSD1. 1 hit.
PRINTSi PR00081. GDHRDH.
PR00080. SDRFAMILY.
TIGRFAMsi TIGR01830. 3oxo_ACP_reduc. 1 hit.
PROSITEi PS00061. ADH_SHORT. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.

Entry informationi

Entry nameiFABG_VIBCH
AccessioniPrimary (citable) accession number: Q9KQH7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: June 20, 2001
Last modified: May 14, 2014
This is version 85 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi