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Q9KQC6 (SYR_VIBCH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Arginine--tRNA ligase

EC=6.1.1.19
Alternative name(s):
Arginyl-tRNA synthetase
Short name=ArgRS
Gene names
Name:argS
Ordered Locus Names:VC_2074
OrganismVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) [Reference proteome] [HAMAP]
Taxonomic identifier243277 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length577 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg). HAMAP-Rule MF_00123

Subunit structure

Monomer By similarity. HAMAP-Rule MF_00123

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00123.

Sequence similarities

Belongs to the class-I aminoacyl-tRNA synthetase family.

Sequence caution

The sequence AAF95220.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processProtein biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionAminoacyl-tRNA synthetase
Ligase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processarginyl-tRNA aminoacylation

Inferred from sequence or structural similarity Ref.1. Source: TIGR

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

arginine-tRNA ligase activity

Inferred from sequence or structural similarity Ref.1. Source: TIGR

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 577577Arginine--tRNA ligase HAMAP-Rule MF_00123
PRO_0000151632

Regions

Motif122 – 13211"HIGH" region HAMAP-Rule MF_00123

Sequences

Sequence LengthMass (Da)Tools
Q9KQC6 [UniParc].

Last modified May 23, 2003. Version 3.
Checksum: 6E6B73420F9DBDE0

FASTA57763,877
        10         20         30         40         50         60 
MNIQALINDR VSQAIEAAGA PAGTPALVRQ SAKAQFGDYQ ANGIMGAAKQ LGTNPREFAQ 

        70         80         90        100        110        120 
KVLDVLNLEG IASKTEIAGP GFINIFLSEE FLAAQAEAAL ADARLGVAQE APKTIVADYS 

       130        140        150        160        170        180 
APNVAKEMHV GHLRSTIIGD AVVRTLEFLG HKVIRANHIG DWGTQFGMLI ANLERVQKAS 

       190        200        210        220        230        240 
GEVSMELSDL EAFYRESKKL YDEDEQFAET ARNYVVKLQG GDPFCLEMWK KLVDVTMIQN 

       250        260        270        280        290        300 
QRNYDRLNVS LTRENVMGES MYNDMLPQIV SDLKAKGLAV EDDGAQVVFL EEFKNKDGEP 

       310        320        330        340        350        360 
MGVIIQKRDG GFLYTTTDIA CAKYRYETLG ADRVLYFIDS RQHQHLMQAW TIVRKAGYIP 

       370        380        390        400        410        420 
ENVSLEHHAF GMMLGKDGRP FKTRAGGTVR LADLLDEAQE RAKALIESKN PELSAEEKAN 

       430        440        450        460        470        480 
IANTVAMAAV KYADLSKHRT TDYVFDWDNM LAFEGNTAPY MQYAYTRVAS VFAKAGVDMN 

       490        500        510        520        530        540 
ELTGHIQITE EKEKALIAKL LQFEEAVQSV AREGQPHIMC SYLFELAGIF SSFYEACPIL 

       550        560        570 
VAEQESIKQS RLKLAALTAK TIKQGLALLG IDTLERM 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE003852 Genomic DNA. Translation: AAF95220.1. Different initiation.
PIRG82121.
RefSeqNP_231706.1. NC_002505.1.

3D structure databases

ProteinModelPortalQ9KQC6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243277.VC2074.

Protocols and materials databases

DNASU2613330.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF95220; AAF95220; VC_2074.
GeneID2613330.
KEGGvch:VC2074.
PATRIC20083181. VBIVibCho83274_1982.

Phylogenomic databases

eggNOGCOG0018.
KOK01887.
OMAIRNTIND.
OrthoDBEOG6JB13C.

Family and domain databases

Gene3D1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPMF_00123. Arg_tRNA_synth.
InterProIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERPTHR11956. PTHR11956. 1 hit.
PfamPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSPR01038. TRNASYNTHARG.
SMARTSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsTIGR00456. argS. 1 hit.
PROSITEPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameSYR_VIBCH
AccessionPrimary (citable) accession number: Q9KQC6
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: May 23, 2003
Last modified: May 14, 2014
This is version 82 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Aminoacyl-tRNA synthetases

List of aminoacyl-tRNA synthetase entries