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Protein

Copper-exporting P-type ATPase

Gene

copA

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in copper export.By similarity

Catalytic activityi

ATP + H2O + Cu+(Side 1) = ADP + phosphate + Cu+(Side 2).

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi22CopperPROSITE-ProRule annotation1
Metal bindingi25CopperPROSITE-ProRule annotation1
Metal bindingi84CopperPROSITE-ProRule annotation1
Metal bindingi87CopperPROSITE-ProRule annotation1
Metal bindingi183CopperPROSITE-ProRule annotation1
Metal bindingi186CopperPROSITE-ProRule annotation1
Active sitei5984-aspartylphosphate intermediateCurated1
Metal bindingi796MagnesiumPROSITE-ProRule annotation1
Metal bindingi800MagnesiumPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • cation transport Source: TIGR
  • copper ion transport Source: UniProtKB-KW

Keywordsi

Molecular functionHydrolase
Biological processCopper transport, Ion transport, Transport
LigandATP-binding, Copper, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVCHO:VC2215-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Copper-exporting P-type ATPase (EC:3.6.3.54)
Alternative name(s):
Copper-exporting P-type ATPase A
Cu(+)-exporting ATPase
Gene namesi
Name:copA
Ordered Locus Names:VC_2215
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000000584 Componenti: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei265 – 285HelicalSequence analysisAdd BLAST21
Transmembranei293 – 313HelicalSequence analysisAdd BLAST21
Transmembranei329 – 349HelicalSequence analysisAdd BLAST21
Transmembranei359 – 379HelicalSequence analysisAdd BLAST21
Transmembranei474 – 494HelicalSequence analysisAdd BLAST21
Transmembranei514 – 534HelicalSequence analysisAdd BLAST21
Transmembranei541 – 561HelicalSequence analysisAdd BLAST21
Transmembranei801 – 821HelicalSequence analysisAdd BLAST21
Transmembranei865 – 885HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000463241 – 915Copper-exporting P-type ATPaseAdd BLAST915

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi243277.VC2215.

Structurei

3D structure databases

ProteinModelPortaliQ9KPZ7.
SMRiQ9KPZ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini12 – 73HMA 1PROSITE-ProRule annotationAdd BLAST62
Domaini74 – 135HMA 2PROSITE-ProRule annotationAdd BLAST62
Domaini173 – 237HMA 3PROSITE-ProRule annotationAdd BLAST65

Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C59. Bacteria.
COG2217. LUCA.
KOiK17686.
OMAiHIFGGPL.

Family and domain databases

CDDicd00371. HMA. 1 hit.
Gene3Di3.40.1110.10. 1 hit.
3.40.50.1000. 1 hit.
InterProiView protein in InterPro
IPR023299. ATPase_P-typ_cyto_dom_N.
IPR018303. ATPase_P-typ_P_site.
IPR023298. ATPase_P-typ_TM_dom_sf.
IPR008250. ATPase_P-typ_transduc_dom_A_sf.
IPR036412. HAD-like_sf.
IPR023214. HAD_sf.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HMA_dom.
IPR036163. HMA_dom_sf.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
PfamiView protein in Pfam
PF00403. HMA. 1 hit.
SUPFAMiSSF55008. SSF55008. 2 hits.
SSF56784. SSF56784. 2 hits.
SSF81653. SSF81653. 1 hit.
SSF81665. SSF81665. 3 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiView protein in PROSITE
PS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 3 hits.

Sequencei

Sequence statusi: Complete.

Q9KPZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIPQGGVIM NHFALALRGL NCMGCARKLE RQLNQDLTVE IETLTPTSIE
60 70 80 90 100
LHTHATLNEV LTSIESLGYQ GGTEQTYQLQ GLNCGRCVNK LTTHLSAQAE
110 120 130 140 150
IAKLHVSKER LSLVTTLTAE QVKALVAEVG YQAIEAEQES TFAPAASIDE
160 170 180 190 200
KETDTPDAEN SSNTEATEAS SQTLSLLIKG MTCASCVASV EKALLSVEGV
210 220 230 240 250
QSAQVNLTEQ SALVRGIFAN PQPLLNAIQS SGYQAEILDD PAQQQAKQQA
260 270 280 290 300
QLEALQKEHK QSALLGIALG TPLMLWGVFG GNMMIRNSSD QMVWGGIGTI
310 320 330 340 350
CFALLLTAGR HFFMNAWQAL THGRATMDTL VALGTGAAWF YSMLVVAWPQ
360 370 380 390 400
TFPDAARHVY FEATAMIIGL ISLGHYIETK AKSNTNRSLQ ALLNLQPQQA
410 420 430 440 450
TLVTEQGDQS IAVADIQLGM SLRIKPGEQV PVDGVVSTGH SYLDESMLTG
460 470 480 490 500
EPIPVLKEAG AKVAAGTLNQ DGSLVITATG IGAQTMLARI IQMVRQAQSS
510 520 530 540 550
KPAMARLADQ ISSVFVPVVV VIAILSAALW YLYGPDPKAS YMLVVATTVL
560 570 580 590 600
IIACPCALGL ATPLSITVGI GKAAEMGILI RDANVLQTAS QVDTVVFDKT
610 620 630 640 650
GTLTLGKPSI QSLHVLQGDE NQLLALAYAL EQQSEHPLAK AICDYAKQRN
660 670 680 690 700
ISPVEISQFT NQRGRGLLAD YQNQTVLVGS LAFMQEQGID LSMAESTLEK
710 720 730 740 750
FAAQAWTPVA VAYRGMLQGV LAIADPIKPT SAQAVRKLNE LGIHTVMLTG
760 770 780 790 800
DHTSVANAIA KELGISQVIA QVLPDQKAQH IQALQQQGRK VAMIGDGIND
810 820 830 840 850
APALALADIG IAMGSGSDVA IESAQMTLLN SSPTSVVSAI ELSKATLRNM
860 870 880 890 900
KQNLFGAFIY NTLGIPIAAG VLYPAFGFLL SPVVAGAAMA LSSITVVSNA
910
NRLRWSKISF DQHSQ
Length:915
Mass (Da):97,312
Last modified:October 1, 2000 - v1
Checksum:i2F31EE2640AD0D20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF95359.1.
PIRiH82104.
RefSeqiNP_231846.1. NC_002505.1.
WP_001881919.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF95359; AAF95359; VC_2215.
GeneIDi2613254.
KEGGivch:VC2215.
PATRICifig|243277.26.peg.2113.

Similar proteinsi

Entry informationi

Entry nameiCOPA_VIBCH
AccessioniPrimary (citable) accession number: Q9KPZ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: October 1, 2000
Last modified: November 22, 2017
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families