Copper-exporting P-type ATPase A

Names and origin

Protein names

Recommended name:
Copper-exporting P-type ATPase A
EC=3.6.3.n1

Gene names

Name:	copA
Ordered Locus Names:	VC_2215

Organism

Vibrio cholerae [Complete proteome] [HAMAP]

Taxonomic identifier

666 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

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Protein attributes

Sequence length	915 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

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General annotation (Comments)

Function	Involved in copper export By similarity.
Catalytic activity	ATP + H₂O + Cu¹⁺(In) = ADP + phosphate + Cu¹⁺(Out).
Subcellular location	Cell membrane; Multi-pass membrane protein Probable.
Sequence similarities	Belongs to the cation transport ATPase (P-type) family. Type IB subfamily. Contains 3 HMA domains.

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Ontologies

Keywords
Biological process	Copper transport Ion transport Transport
Cellular component	Cell membrane Membrane
Domain	Repeat Transmembrane
Ligand	ATP-binding Copper Magnesium Metal-binding Nucleotide-binding
Molecular function	Hydrolase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	ATP biosynthetic process Inferred from electronic annotation. Source: InterPro copper ion transport Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW plasma membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW copper ion binding Inferred from electronic annotation. Source: UniProtKB-KW copper-exporting ATPase activity Inferred from electronic annotation. Source: InterPro magnesium ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

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Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 915

915

Copper-exporting P-type ATPase A

PRO_0000046324

Regions

Transmembrane

265 – 285

21

Potential

Transmembrane

293 – 313

21

Potential

Transmembrane

329 – 349

21

Potential

Transmembrane

359 – 379

21

Potential

Transmembrane

474 – 494

21

Potential

Transmembrane

514 – 534

21

Potential

Transmembrane

541 – 561

21

Potential

Transmembrane

801 – 821

21

Potential

Transmembrane

865 – 885

21

Potential

Domain

12 – 73

62

HMA 1

Domain

74 – 135

62

HMA 2

Domain

173 – 237

65

HMA 3

Sites

Active site

598

1

4-aspartylphosphate intermediate Probable

Metal binding

22

1

Copper Potential

Metal binding

25

1

Copper Potential

Metal binding

84

1

Copper Potential

Metal binding

87

1

Copper Potential

Metal binding

183

1

Copper Potential

Metal binding

186

1

Copper Potential

Metal binding

796

1

Magnesium By similarity

Metal binding

800

1

Magnesium By similarity

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Sequences

Sequence

Length

Mass (Da)

Tools

Q9KPZ7-1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 2F31EE2640AD0D20
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FASTA

915

97,312

        10         20         30         40         50         60 
MDIPQGGVIM NHFALALRGL NCMGCARKLE RQLNQDLTVE IETLTPTSIE LHTHATLNEV 

        70         80         90        100        110        120 
LTSIESLGYQ GGTEQTYQLQ GLNCGRCVNK LTTHLSAQAE IAKLHVSKER LSLVTTLTAE 

       130        140        150        160        170        180 
QVKALVAEVG YQAIEAEQES TFAPAASIDE KETDTPDAEN SSNTEATEAS SQTLSLLIKG 

       190        200        210        220        230        240 
MTCASCVASV EKALLSVEGV QSAQVNLTEQ SALVRGIFAN PQPLLNAIQS SGYQAEILDD 

       250        260        270        280        290        300 
PAQQQAKQQA QLEALQKEHK QSALLGIALG TPLMLWGVFG GNMMIRNSSD QMVWGGIGTI 

       310        320        330        340        350        360 
CFALLLTAGR HFFMNAWQAL THGRATMDTL VALGTGAAWF YSMLVVAWPQ TFPDAARHVY 

       370        380        390        400        410        420 
FEATAMIIGL ISLGHYIETK AKSNTNRSLQ ALLNLQPQQA TLVTEQGDQS IAVADIQLGM 

       430        440        450        460        470        480 
SLRIKPGEQV PVDGVVSTGH SYLDESMLTG EPIPVLKEAG AKVAAGTLNQ DGSLVITATG 

       490        500        510        520        530        540 
IGAQTMLARI IQMVRQAQSS KPAMARLADQ ISSVFVPVVV VIAILSAALW YLYGPDPKAS 

       550        560        570        580        590        600 
YMLVVATTVL IIACPCALGL ATPLSITVGI GKAAEMGILI RDANVLQTAS QVDTVVFDKT 

       610        620        630        640        650        660 
GTLTLGKPSI QSLHVLQGDE NQLLALAYAL EQQSEHPLAK AICDYAKQRN ISPVEISQFT 

       670        680        690        700        710        720 
NQRGRGLLAD YQNQTVLVGS LAFMQEQGID LSMAESTLEK FAAQAWTPVA VAYRGMLQGV 

       730        740        750        760        770        780 
LAIADPIKPT SAQAVRKLNE LGIHTVMLTG DHTSVANAIA KELGISQVIA QVLPDQKAQH 

       790        800        810        820        830        840 
IQALQQQGRK VAMIGDGIND APALALADIG IAMGSGSDVA IESAQMTLLN SSPTSVVSAI 

       850        860        870        880        890        900 
ELSKATLRNM KQNLFGAFIY NTLGIPIAAG VLYPAFGFLL SPVVAGAAMA LSSITVVSNA 

       910 
NRLRWSKISF DQHSQ

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References

[1]

"DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae."
Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R., Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D., Vamathevan J.J., Bass S.

Fraser C.M.
Nature 406:477-483(2000) [PubMed: 10952301] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 39315 / El Tor Inaba N16961 / Serotype O1.

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Cross-references

Sequence databases
	AE003852 Genomic DNA. Translation: AAF95359.1.
PIR	H82104.
RefSeq	NP_231846.1.
3D structure databases
HSSP	HSSP built from PDB template 1CPZ based on UniProtKB Q47840.
ModBase	Search...
Genome annotation databases
GeneID	2613254.
GenomeReviews	Gene locus VC_2215 in contig AE003852_GR.
KEGG	vch:VC2215.
TIGR	VC_2215.
Phylogenomic databases
HOGENOM	Q9KPZ7.
OMA	Q9KPZ7. EMMINSP.
Enzyme and pathway databases
BRENDA	3.6.3.4. 19019.
Family and domain databases
InterPro	IPR008250. ATPase_P-typ_ATPase-assoc-reg. IPR006403. ATPase_P-typ_cat/Cu-transptr. IPR000579. ATPase_P-typ_cation-transptr. IPR006416. ATPase_P-typ_heavy-metal. IPR001757. ATPase_P-typ_ion-transptr. IPR018303. ATPase_P-typ_phosphor_site. IPR005834. Dehalogen-like_hydro. IPR017969. Heavy-metal-associated_CS. IPR006121. HeavyMe_transpt. [Graphical view]
PANTHER	PTHR11939. ATPase_P. 1 hit.
Pfam	PF00122. E1-E2_ATPase. 1 hit. PF00403. HMA. 1 hit. PF00702. Hydrolase. 1 hit. [Graphical view]
PRINTS	PR00119. CATATPASE. PR00940. CATPATPASEA.
TIGRFAMs	TIGR01511. ATPase-IB1_Cu. 1 hit. TIGR01525. ATPase-IB_hvy. 1 hit. TIGR01494. ATPase_P-type. 1 hit.
PROSITE	PS00154. ATPASE_E1_E2. 1 hit. PS01047. HMA_1. 1 hit. PS50846. HMA_2. 3 hits. [Graphical view]
ProtoNet	Search...

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Entry information

Entry name

COPA_VIBCH

Accession

Primary (citable) accession number: Q9KPZ7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 3, 2002
Last sequence update:	October 1, 2000
Last modified:	June 16, 2009
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Sequences

References

Cross-references

Sequence databases

3D structure databases

Genome annotation databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

Entry information

Relevant documents