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Protein

Copper-exporting P-type ATPase A

Gene

copA

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in copper export.By similarity

Catalytic activityi

ATP + H2O + Cu+(Side 1) = ADP + phosphate + Cu+(Side 2).

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi22 – 221CopperPROSITE-ProRule annotation
Metal bindingi25 – 251CopperPROSITE-ProRule annotation
Metal bindingi84 – 841CopperPROSITE-ProRule annotation
Metal bindingi87 – 871CopperPROSITE-ProRule annotation
Metal bindingi183 – 1831CopperPROSITE-ProRule annotation
Metal bindingi186 – 1861CopperPROSITE-ProRule annotation
Active sitei598 – 59814-aspartylphosphate intermediateCurated
Metal bindingi796 – 7961MagnesiumPROSITE-ProRule annotation
Metal bindingi800 – 8001MagnesiumPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

  • cation transport Source: TIGR
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Copper transport, Ion transport, Transport

Keywords - Ligandi

ATP-binding, Copper, Magnesium, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVCHO:VC2215-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Copper-exporting P-type ATPase A (EC:3.6.3.54)
Alternative name(s):
Cu(+)-exporting ATPase
Gene namesi
Name:copA
Ordered Locus Names:VC_2215
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000000584 Componenti: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei265 – 28521HelicalSequence analysisAdd
BLAST
Transmembranei293 – 31321HelicalSequence analysisAdd
BLAST
Transmembranei329 – 34921HelicalSequence analysisAdd
BLAST
Transmembranei359 – 37921HelicalSequence analysisAdd
BLAST
Transmembranei474 – 49421HelicalSequence analysisAdd
BLAST
Transmembranei514 – 53421HelicalSequence analysisAdd
BLAST
Transmembranei541 – 56121HelicalSequence analysisAdd
BLAST
Transmembranei801 – 82121HelicalSequence analysisAdd
BLAST
Transmembranei865 – 88521HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 915915Copper-exporting P-type ATPase APRO_0000046324Add
BLAST

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi243277.VC2215.

Structurei

3D structure databases

ProteinModelPortaliQ9KPZ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini12 – 7362HMA 1PROSITE-ProRule annotationAdd
BLAST
Domaini74 – 13562HMA 2PROSITE-ProRule annotationAdd
BLAST
Domaini173 – 23765HMA 3PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 3 HMA domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C59. Bacteria.
COG2217. LUCA.
KOiK17686.
OMAiQDGSTDH.
OrthoDBiEOG6742RM.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 1 hit.
[Graphical view]
SUPFAMiSSF55008. SSF55008. 2 hits.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 3 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KPZ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDIPQGGVIM NHFALALRGL NCMGCARKLE RQLNQDLTVE IETLTPTSIE
60 70 80 90 100
LHTHATLNEV LTSIESLGYQ GGTEQTYQLQ GLNCGRCVNK LTTHLSAQAE
110 120 130 140 150
IAKLHVSKER LSLVTTLTAE QVKALVAEVG YQAIEAEQES TFAPAASIDE
160 170 180 190 200
KETDTPDAEN SSNTEATEAS SQTLSLLIKG MTCASCVASV EKALLSVEGV
210 220 230 240 250
QSAQVNLTEQ SALVRGIFAN PQPLLNAIQS SGYQAEILDD PAQQQAKQQA
260 270 280 290 300
QLEALQKEHK QSALLGIALG TPLMLWGVFG GNMMIRNSSD QMVWGGIGTI
310 320 330 340 350
CFALLLTAGR HFFMNAWQAL THGRATMDTL VALGTGAAWF YSMLVVAWPQ
360 370 380 390 400
TFPDAARHVY FEATAMIIGL ISLGHYIETK AKSNTNRSLQ ALLNLQPQQA
410 420 430 440 450
TLVTEQGDQS IAVADIQLGM SLRIKPGEQV PVDGVVSTGH SYLDESMLTG
460 470 480 490 500
EPIPVLKEAG AKVAAGTLNQ DGSLVITATG IGAQTMLARI IQMVRQAQSS
510 520 530 540 550
KPAMARLADQ ISSVFVPVVV VIAILSAALW YLYGPDPKAS YMLVVATTVL
560 570 580 590 600
IIACPCALGL ATPLSITVGI GKAAEMGILI RDANVLQTAS QVDTVVFDKT
610 620 630 640 650
GTLTLGKPSI QSLHVLQGDE NQLLALAYAL EQQSEHPLAK AICDYAKQRN
660 670 680 690 700
ISPVEISQFT NQRGRGLLAD YQNQTVLVGS LAFMQEQGID LSMAESTLEK
710 720 730 740 750
FAAQAWTPVA VAYRGMLQGV LAIADPIKPT SAQAVRKLNE LGIHTVMLTG
760 770 780 790 800
DHTSVANAIA KELGISQVIA QVLPDQKAQH IQALQQQGRK VAMIGDGIND
810 820 830 840 850
APALALADIG IAMGSGSDVA IESAQMTLLN SSPTSVVSAI ELSKATLRNM
860 870 880 890 900
KQNLFGAFIY NTLGIPIAAG VLYPAFGFLL SPVVAGAAMA LSSITVVSNA
910
NRLRWSKISF DQHSQ
Length:915
Mass (Da):97,312
Last modified:October 1, 2000 - v1
Checksum:i2F31EE2640AD0D20
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF95359.1.
PIRiH82104.
RefSeqiNP_231846.1. NC_002505.1.
WP_001881919.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF95359; AAF95359; VC_2215.
GeneIDi2613254.
KEGGivch:VC2215.
PATRICi20083475. VBIVibCho83274_2113.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF95359.1.
PIRiH82104.
RefSeqiNP_231846.1. NC_002505.1.
WP_001881919.1. NC_002505.1.

3D structure databases

ProteinModelPortaliQ9KPZ7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243277.VC2215.

Protocols and materials databases

DNASUi2613254.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF95359; AAF95359; VC_2215.
GeneIDi2613254.
KEGGivch:VC2215.
PATRICi20083475. VBIVibCho83274_2113.

Phylogenomic databases

eggNOGiENOG4105C59. Bacteria.
COG2217. LUCA.
KOiK17686.
OMAiQDGSTDH.
OrthoDBiEOG6742RM.

Enzyme and pathway databases

BioCyciVCHO:VC2215-MONOMER.

Family and domain databases

Gene3Di2.70.150.10. 1 hit.
3.40.1110.10. 1 hit.
3.40.50.1000. 2 hits.
InterProiIPR023299. ATPase_P-typ_cyto_domN.
IPR018303. ATPase_P-typ_P_site.
IPR008250. ATPase_P-typ_transduc_dom_A.
IPR023214. HAD-like_dom.
IPR017969. Heavy-metal-associated_CS.
IPR006121. HMA_dom.
IPR027256. P-typ_ATPase_IB.
IPR001757. P_typ_ATPase.
[Graphical view]
PfamiPF00122. E1-E2_ATPase. 1 hit.
PF00403. HMA. 1 hit.
[Graphical view]
SUPFAMiSSF55008. SSF55008. 2 hits.
SSF56784. SSF56784. 2 hits.
TIGRFAMsiTIGR01525. ATPase-IB_hvy. 1 hit.
TIGR01494. ATPase_P-type. 1 hit.
PROSITEiPS00154. ATPASE_E1_E2. 1 hit.
PS01047. HMA_1. 1 hit.
PS50846. HMA_2. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.

Entry informationi

Entry nameiCOPA_VIBCH
AccessioniPrimary (citable) accession number: Q9KPZ7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 3, 2002
Last sequence update: October 1, 2000
Last modified: July 6, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.