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Q9KPY6 (PUR5_VIBCH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosylformylglycinamidine cyclo-ligase

EC=6.3.3.1
Alternative name(s):
AIR synthase
AIRS
Phosphoribosyl-aminoimidazole synthetase
Gene names
Name:purM
Ordered Locus Names:VC_2226
OrganismVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) [Reference proteome] [HAMAP]
Taxonomic identifier243277 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length346 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP-Rule MF_00741

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP-Rule MF_00741

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00741.

Sequence similarities

Belongs to the AIR synthase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 346346Phosphoribosylformylglycinamidine cyclo-ligase HAMAP-Rule MF_00741
PRO_0000148270

Secondary structure

................................................. 346
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Q9KPY6 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: D440BA2570E5DC0D

FASTA34636,773
        10         20         30         40         50         60 
MSGNNPSLSY KDAGVDIDAG NALVERIKGA VKRTRRPEVM GGLGGFGALC ELPTKYKHPV 

        70         80         90        100        110        120 
LVSGTDGVGT KLRLALDMKK HDTIGIDLVA MCVNDLIVQG AEPLFFLDYY ATGKLDVDTA 

       130        140        150        160        170        180 
AEVISGIADG CLQAGCALIG GETAEMPGMY EGEDYDVAGF CVGVVEKEEI IDGSKVQVGD 

       190        200        210        220        230        240 
ALIAVGSSGP HSNGYSLVRK ILEVSKADKN ERLAGKTIGE HLLAPTKIYI KSGLKLIAEH 

       250        260        270        280        290        300 
DIHAISHITG GGFWENIPRV LPEGTKAVID GKSWEWPVIF QWLQEKGNVT THEMYRTFNC 

       310        320        330        340 
GVGLIIALPK DQANAAVALL QAEGETAWVI GEIAAANSNE AQVEIN 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE003852 Genomic DNA. Translation: AAF95370.1.
PIRF82103.
RefSeqNP_231857.1. NC_002505.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
3P4EX-ray1.77A1-346[»]
ProteinModelPortalQ9KPY6.
SMRQ9KPY6. Positions 7-343.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243277.VC2226.

Protocols and materials databases

DNASU2613266.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF95370; AAF95370; VC_2226.
GeneID2613266.
KEGGvch:VC2226.
PATRIC20083499. VBIVibCho83274_2124.

Phylogenomic databases

eggNOGCOG0150.
KOK01933.
OMAHCVNDIL.
OrthoDBEOG61CM1V.
ProtClustDBPRK05385.

Enzyme and pathway databases

BioCycVCHO:VC2226-MONOMER.
UniPathwayUPA00074; UER00129.

Family and domain databases

Gene3D3.90.650.10. 1 hit.
HAMAPMF_00741_B. AIRS_B.
InterProIPR010918. AIR_synth_C_dom.
IPR000728. AIR_synth_N_dom.
IPR004733. PurM_cligase.
IPR016188. PurM_N-like.
[Graphical view]
PfamPF00586. AIRS. 1 hit.
PF02769. AIRS_C. 1 hit.
[Graphical view]
SUPFAMSSF55326. SSF55326. 1 hit.
SSF56042. SSF56042. 1 hit.
TIGRFAMsTIGR00878. purM. 1 hit.
ProtoNetSearch...

Other

EvolutionaryTraceQ9KPY6.

Entry information

Entry namePUR5_VIBCH
AccessionPrimary (citable) accession number: Q9KPY6
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: October 1, 2000
Last modified: February 19, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

PATHWAY comments

Index of metabolic and biosynthesis pathways