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Q9KPW5 (LPXB_VIBCH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 70. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipid-A-disaccharide synthase

EC=2.4.1.182
Gene names
Name:lpxB
Ordered Locus Names:VC_2247
OrganismVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) [Reference proteome] [HAMAP]
Taxonomic identifier243277 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length379 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392

Catalytic activity

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392

Sequence similarities

Belongs to the LpxB family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 379379Lipid-A-disaccharide synthase HAMAP-Rule MF_00392
PRO_0000190188

Sequences

Sequence LengthMass (Da)Tools
Q9KPW5 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 646808F3DDFA3CCE

FASTA37942,250
        10         20         30         40         50         60 
MNRPLRIGIV VGELSGDTLG EGFIKAIRAR YPDAEFVGIG GPKMNALGCQ SLFDMEELAV 

        70         80         90        100        110        120 
MGLVEVLGRL PRLLKVKAEL VKYFTANPPD VFVGIDAPDF NLRLELSLKQ AGIKTVHYVS 

       130        140        150        160        170        180 
PSVWAWRQNR IHGIAAATHL VLAFLPFEKA FYDKFNVPCE FIGHTLADSI PLASDKLAAR 

       190        200        210        220        230        240 
QLLGLDEQRR WLAVLPGSRG SEMKMLAEPF IATCQKLQAR YPDLGFVVAL VNAKRRAQFE 

       250        260        270        280        290        300 
QAWQQVAPEL NFVLVDDTAR NVITAADAVM LASGTVALEC MLLKRPMVVG YRVNAFTAFL 

       310        320        330        340        350        360 
AKRLLKTPYV SLPNILAGEE LVKELLQDHC TVDNLYHEVS RLLESDNQAL MDKFTEMHQW 

       370 
IRKDADQQAA QAVLHLIQK 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE003852 Genomic DNA. Translation: AAF95391.1.
PIRA82101.
RefSeqNP_231878.1. NC_002505.1.

3D structure databases

ProteinModelPortalQ9KPW5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243277.VC2247.

Protein family/group databases

CAZyGT19. Glycosyltransferase Family 19.

Protocols and materials databases

DNASU2613169.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF95391; AAF95391; VC_2247.
GeneID2613169.
KEGGvch:VC2247.
PATRIC20083537. VBIVibCho83274_2143.

Phylogenomic databases

eggNOGCOG0763.
KOK00748.
OMAVSPITYR.
OrthoDBEOG6FBWZR.

Enzyme and pathway databases

BioCycVCHO:VC2247-MONOMER.
UniPathwayUPA00359; UER00481.

Family and domain databases

HAMAPMF_00392. LpxB.
InterProIPR003835. Glyco_trans_19.
[Graphical view]
PfamPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00215. lpxB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXB_VIBCH
AccessionPrimary (citable) accession number: Q9KPW5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 1, 2001
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways