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Q9KPS2

- NQRB_VIBCH

UniProt

Q9KPS2 - NQRB_VIBCH

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Protein

Na(+)-translocating NADH-quinone reductase subunit B

Gene
nqrB, VC_2294
Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na+ ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol.UniRule annotation

Catalytic activityi

NADH + ubiquinone + Na+(In) = NAD+ + ubiquinol + Na+(Out).UniRule annotation

Cofactori

FMN By similarity.UniRule annotation

GO - Molecular functioni

  1. FMN binding Source: InterPro
  2. NADH dehydrogenase (ubiquinone) activity Source: TIGR

GO - Biological processi

  1. respiratory electron transport chain Source: InterPro
  2. sodium ion transport Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Ion transport, Sodium transport, Transport

Keywords - Ligandi

Flavoprotein, FMN, NAD, Sodium, Ubiquinone

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-16198.

Names & Taxonomyi

Protein namesi
Recommended name:
Na(+)-translocating NADH-quinone reductase subunit B (EC:1.6.5.-)
Short name:
Na(+)-NQR subunit B
Short name:
Na(+)-translocating NQR subunit B
Alternative name(s):
NQR complex subunit B
NQR-1 subunit B
Gene namesi
Name:nqrB
Ordered Locus Names:VC_2294
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584: Chromosome 1

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei23 – 4018Helical; Reviewed predictionAdd
BLAST
Transmembranei60 – 8223Helical; Reviewed predictionAdd
BLAST
Transmembranei125 – 14723Helical; Reviewed predictionAdd
BLAST
Transmembranei159 – 18123Helical; Reviewed predictionAdd
BLAST
Transmembranei270 – 29223Helical; Reviewed predictionAdd
BLAST
Transmembranei297 – 31620Helical; Reviewed predictionAdd
BLAST
Transmembranei326 – 34520Helical; Reviewed predictionAdd
BLAST
Transmembranei358 – 37518Helical; Reviewed predictionAdd
BLAST
Transmembranei379 – 40123Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. Gram-negative-bacterium-type cell wall Source: InterPro
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 415415Na(+)-translocating NADH-quinone reductase subunit BUniRule annotationPRO_0000074444Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei236 – 2361FMN phosphoryl threonine By similarity

Keywords - PTMi

Phosphoprotein

Interactioni

Subunit structurei

Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF By similarity.

Protein-protein interaction databases

STRINGi243277.VC2294.

Family & Domainsi

Sequence similaritiesi

Belongs to the NqrB/RnfD family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1805.
KOiK00347.
OMAiTVFYTPG.
OrthoDBiEOG65BDMX.

Family and domain databases

HAMAPiMF_00426. NqrB.
InterProiIPR010966. NADH-UbQ_OxRdtase_suB.
IPR004338. NADH_Q_Rdtase_NQR2_RnfD.
[Graphical view]
PfamiPF03116. NQR2_RnfD_RnfE. 1 hit.
[Graphical view]
PIRSFiPIRSF016055. NADH-UbQ_OxRdtase_B_su. 1 hit.
TIGRFAMsiTIGR01937. nqrB. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9KPS2-1 [UniParc]FASTAAdd to Basket

« Hide

MGLKKFLEDI EHHFEPGGKH EKWFALYEAA ATLFYTPGLV TKRSSHVRDS    50
VDLKRIMIMV WLAVFPAMFW GMYNAGGQAI AALNHLYSGD QLAAIVAGNW 100
HYWLTEMLGG TMSSDAGWGS KMLLGATYFL PIYATVFIVG GFWEVLFCMV 150
RKHEVNEGFF VTSILFALIV PPTLPLWQAA LGITFGVVVA KEVFGGTGRN 200
FLNPALAGRA FLFFAYPAQI SGDLVWTAAD GYSGATALSQ WAQGGAGALI 250
NNATGQTITW MDAFIGNIPG SIGEVSTLAL MIGAAFIVYM GIASWRIIGG 300
VMIGMILLST LFNVIGSDTN AMFNMPWHWH LVLGGFAFGM FFMATDPVSA 350
SFTNSGKWAY GILIGVMCVL IRVVNPAYPE GMMLAILFAN LFAPLFDHVV 400
VERNIKRRLA RYGKQ 415
Length:415
Mass (Da):45,357
Last modified:August 14, 2001 - v2
Checksum:i8DF4F1FD6DAE8DAF
GO

Sequence cautioni

The sequence AAF95438.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF117331 Genomic DNA. Translation: AAD29963.1.
AE003852 Genomic DNA. Translation: AAF95438.1. Different initiation.
PIRiF82094.
RefSeqiNP_231925.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF95438; AAF95438; VC_2294.
GeneIDi2613216.
KEGGivch:VC2294.
PATRICi20083627. VBIVibCho83274_2188.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF117331 Genomic DNA. Translation: AAD29963.1 .
AE003852 Genomic DNA. Translation: AAF95438.1 . Different initiation.
PIRi F82094.
RefSeqi NP_231925.1. NC_002505.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243277.VC2294.

Protocols and materials databases

DNASUi 2613216.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF95438 ; AAF95438 ; VC_2294 .
GeneIDi 2613216.
KEGGi vch:VC2294.
PATRICi 20083627. VBIVibCho83274_2188.

Phylogenomic databases

eggNOGi COG1805.
KOi K00347.
OMAi TVFYTPG.
OrthoDBi EOG65BDMX.

Enzyme and pathway databases

BioCyci MetaCyc:MONOMER-16198.

Family and domain databases

HAMAPi MF_00426. NqrB.
InterProi IPR010966. NADH-UbQ_OxRdtase_suB.
IPR004338. NADH_Q_Rdtase_NQR2_RnfD.
[Graphical view ]
Pfami PF03116. NQR2_RnfD_RnfE. 1 hit.
[Graphical view ]
PIRSFi PIRSF016055. NADH-UbQ_OxRdtase_B_su. 1 hit.
TIGRFAMsi TIGR01937. nqrB. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Effects of changes in membrane sodium flux on virulence gene expression in Vibrio cholerae."
    Haese C.C., Mekalanos J.J.
    Proc. Natl. Acad. Sci. U.S.A. 96:3183-3187(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.

Entry informationi

Entry nameiNQRB_VIBCH
AccessioniPrimary (citable) accession number: Q9KPS2
Secondary accession number(s): Q9X4Q4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: August 14, 2001
Last modified: May 14, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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