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Q9KPS2 (NQRB_VIBCH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Na(+)-translocating NADH-quinone reductase subunit B

Short name=Na(+)-NQR subunit B
Short name=Na(+)-translocating NQR subunit B
EC=1.6.5.-
Alternative name(s):
NQR complex subunit B
NQR-1 subunit B
Gene names
Name:nqrB
Ordered Locus Names:VC_2294
OrganismVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) [Reference proteome] [HAMAP]
Taxonomic identifier243277 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length415 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NQR complex catalyzes the reduction of ubiquinone-1 to ubiquinol by two successive reactions, coupled with the transport of Na+ ions from the cytoplasm to the periplasm. NqrA to NqrE are probably involved in the second step, the conversion of ubisemiquinone to ubiquinol. HAMAP-Rule MF_00426

Catalytic activity

NADH + ubiquinone + Na+(In) = NAD+ + ubiquinol + Na+(Out). HAMAP-Rule MF_00426

Cofactor

FMN By similarity. HAMAP-Rule MF_00426

Subunit structure

Composed of six subunits; NqrA, NqrB, NqrC, NqrD, NqrE and NqrF By similarity.

Subcellular location

Cell inner membrane; Multi-pass membrane protein Potential HAMAP-Rule MF_00426.

Sequence similarities

Belongs to the NqrB/RnfD family.

Sequence caution

The sequence AAF95438.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 415415Na(+)-translocating NADH-quinone reductase subunit B HAMAP-Rule MF_00426
PRO_0000074444

Regions

Transmembrane23 – 4018Helical; Potential
Transmembrane60 – 8223Helical; Potential
Transmembrane125 – 14723Helical; Potential
Transmembrane159 – 18123Helical; Potential
Transmembrane270 – 29223Helical; Potential
Transmembrane297 – 31620Helical; Potential
Transmembrane326 – 34520Helical; Potential
Transmembrane358 – 37518Helical; Potential
Transmembrane379 – 40123Helical; Potential

Amino acid modifications

Modified residue2361FMN phosphoryl threonine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9KPS2 [UniParc].

Last modified August 14, 2001. Version 2.
Checksum: 8DF4F1FD6DAE8DAF

FASTA41545,357
        10         20         30         40         50         60 
MGLKKFLEDI EHHFEPGGKH EKWFALYEAA ATLFYTPGLV TKRSSHVRDS VDLKRIMIMV 

        70         80         90        100        110        120 
WLAVFPAMFW GMYNAGGQAI AALNHLYSGD QLAAIVAGNW HYWLTEMLGG TMSSDAGWGS 

       130        140        150        160        170        180 
KMLLGATYFL PIYATVFIVG GFWEVLFCMV RKHEVNEGFF VTSILFALIV PPTLPLWQAA 

       190        200        210        220        230        240 
LGITFGVVVA KEVFGGTGRN FLNPALAGRA FLFFAYPAQI SGDLVWTAAD GYSGATALSQ 

       250        260        270        280        290        300 
WAQGGAGALI NNATGQTITW MDAFIGNIPG SIGEVSTLAL MIGAAFIVYM GIASWRIIGG 

       310        320        330        340        350        360 
VMIGMILLST LFNVIGSDTN AMFNMPWHWH LVLGGFAFGM FFMATDPVSA SFTNSGKWAY 

       370        380        390        400        410 
GILIGVMCVL IRVVNPAYPE GMMLAILFAN LFAPLFDHVV VERNIKRRLA RYGKQ 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF117331 Genomic DNA. Translation: AAD29963.1.
AE003852 Genomic DNA. Translation: AAF95438.1. Different initiation.
PIRF82094.
RefSeqNP_231925.1. NC_002505.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243277.VC2294.

Protocols and materials databases

DNASU2613216.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF95438; AAF95438; VC_2294.
GeneID2613216.
KEGGvch:VC2294.
PATRIC20083627. VBIVibCho83274_2188.

Phylogenomic databases

eggNOGCOG1805.
KOK00347.
OMATIPLWQV.
OrthoDBEOG65BDMX.
ProtClustDBPRK05349.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-16198.

Family and domain databases

HAMAPMF_00426. NqrB.
InterProIPR010966. NADH-UbQ_OxRdtase_suB.
IPR004338. NADH_Q_Rdtase_NQR2_RnfD.
[Graphical view]
PfamPF03116. NQR2_RnfD_RnfE. 1 hit.
[Graphical view]
PIRSFPIRSF016055. NADH-UbQ_OxRdtase_B_su. 1 hit.
TIGRFAMsTIGR01937. nqrB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNQRB_VIBCH
AccessionPrimary (citable) accession number: Q9KPS2
Secondary accession number(s): Q9X4Q4
Entry history
Integrated into UniProtKB/Swiss-Prot: August 14, 2001
Last sequence update: August 14, 2001
Last modified: February 19, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families