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Q9KPQ9

- PANE_VIBCH

UniProt

Q9KPQ9 - PANE_VIBCH

Protein

2-dehydropantoate 2-reductase

Gene

panE

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 88 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

    Catalytic activityi

    (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei31 – 311NADP; via amide nitrogenBy similarity
    Binding sitei94 – 941NADP; via amide nitrogenBy similarity
    Binding sitei94 – 941SubstrateBy similarity
    Binding sitei120 – 1201NADP; via amide nitrogen and carbonyl oxygenBy similarity
    Active sitei175 – 1751Proton donorBy similarity
    Binding sitei179 – 1791SubstrateBy similarity
    Binding sitei183 – 1831SubstrateBy similarity
    Binding sitei193 – 1931SubstrateBy similarity
    Binding sitei242 – 2421SubstrateBy similarity
    Binding sitei245 – 2451SubstrateBy similarity
    Binding sitei257 – 2571NADPBy similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi7 – 126NADPBy similarity

    GO - Molecular functioni

    1. 2-dehydropantoate 2-reductase activity Source: TIGR
    2. NADP binding Source: InterPro

    GO - Biological processi

    1. pantothenate biosynthetic process Source: TIGR

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    NADP

    Enzyme and pathway databases

    BioCyciVCHO:VC2307-MONOMER.
    UniPathwayiUPA00028; UER00004.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    2-dehydropantoate 2-reductase (EC:1.1.1.169)
    Alternative name(s):
    Ketopantoate reductase
    Short name:
    KPA reductase
    Short name:
    KPR
    Gene namesi
    Name:panE
    Ordered Locus Names:VC_2307
    OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
    Taxonomic identifieri243277 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000000584: Chromosome 1

    Subcellular locationi

    Cytoplasm Curated

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 2962962-dehydropantoate 2-reductasePRO_0000157306Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243277.VC2307.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9KPQ9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the ketopantoate reductase family.Curated

    Phylogenomic databases

    eggNOGiCOG1893.
    KOiK00077.
    OMAiSQCHILL.
    OrthoDBiEOG68SVW3.

    Family and domain databases

    Gene3Di1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProiIPR008927. 6-PGluconate_DH_C-like.
    IPR003710. ApbA.
    IPR013328. DH_multihelical.
    IPR013752. KPA_reductase.
    IPR013332. KPR_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PfamiPF02558. ApbA. 1 hit.
    PF08546. ApbA_C. 1 hit.
    [Graphical view]
    SUPFAMiSSF48179. SSF48179. 1 hit.
    TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9KPQ9-1 [UniParc]FASTAAdd to Basket

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    MNIVVLGPGA VGSLWALHLH SAGHQVALWS RQAQPTITLQ LDEEAPISFR    50
    NQNLDTLIHA DLLLITVKAW QVEAALQPLL PHLNRETILL FMHNGMGAVE 100
    AISESLTHFP VLFATTTHGA LKATLNQVSH TGFGQTQVGP FNALGARCDF 150
    IADVFNHALA PVTWNPEIQQ ALWRKLAVNC AINPLTAIHQ CANGALVAPE 200
    FTPIITAILD EVTAVMQAEA ISGEAEALRD GVYQVIQATA ANLSSMHQDV 250
    FHRRPTEIDF ITGYVVRKGE QHGIATPVNS ALYQQIKTLE QSWSKA 296
    Length:296
    Mass (Da):32,201
    Last modified:October 1, 2000 - v1
    Checksum:iA594D8EAFEE5EEAD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE003852 Genomic DNA. Translation: AAF95451.1.
    PIRiD82092.
    RefSeqiNP_231938.1. NC_002505.1.

    Genome annotation databases

    EnsemblBacteriaiAAF95451; AAF95451; VC_2307.
    GeneIDi2613103.
    KEGGivch:VC2307.
    PATRICi20083649. VBIVibCho83274_2199.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE003852 Genomic DNA. Translation: AAF95451.1 .
    PIRi D82092.
    RefSeqi NP_231938.1. NC_002505.1.

    3D structure databases

    ProteinModelPortali Q9KPQ9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243277.VC2307.

    Protocols and materials databases

    DNASUi 2613103.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF95451 ; AAF95451 ; VC_2307 .
    GeneIDi 2613103.
    KEGGi vch:VC2307.
    PATRICi 20083649. VBIVibCho83274_2199.

    Phylogenomic databases

    eggNOGi COG1893.
    KOi K00077.
    OMAi SQCHILL.
    OrthoDBi EOG68SVW3.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00004 .
    BioCyci VCHO:VC2307-MONOMER.

    Family and domain databases

    Gene3Di 1.10.1040.10. 1 hit.
    3.40.50.720. 1 hit.
    InterProi IPR008927. 6-PGluconate_DH_C-like.
    IPR003710. ApbA.
    IPR013328. DH_multihelical.
    IPR013752. KPA_reductase.
    IPR013332. KPR_N.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    Pfami PF02558. ApbA. 1 hit.
    PF08546. ApbA_C. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48179. SSF48179. 1 hit.
    TIGRFAMsi TIGR00745. apbA_panE. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39315 / El Tor Inaba N16961.

    Entry informationi

    Entry nameiPANE_VIBCH
    AccessioniPrimary (citable) accession number: Q9KPQ9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 21, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 88 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3