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Q9KPQ9 (PANE_VIBCH) Reviewed, UniProtKB/Swiss-Prot

Last modified December 11, 2013. Version 85. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
2-dehydropantoate 2-reductase

EC=1.1.1.169
Alternative name(s):
Ketopantoate reductase
Short name=KPA reductase
Short name=KPR
Gene names
Name:panE
Ordered Locus Names:VC_2307
OrganismVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) [Reference proteome] [HAMAP]
Taxonomic identifier243277 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length296 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

Catalytic activity

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathway

Cofactor biosynthesis; (R)-pantothenate biosynthesis; (R)-pantoate from 3-methyl-2-oxobutanoate: step 2/2.

Subcellular location

Cytoplasm Potential.

Sequence similarities

Belongs to the ketopantoate reductase family.

Ontologies

Keywords
   Biological processPantothenate biosynthesis
   Cellular componentCytoplasm
   LigandNADP
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processpantothenate biosynthetic process

Inferred from sequence or structural similarity Ref.1. Source: TIGR

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_function2-dehydropantoate 2-reductase activity

Inferred from sequence or structural similarity Ref.1. Source: TIGR

NADP binding

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2962962-dehydropantoate 2-reductase
PRO_0000157306

Regions

Nucleotide binding7 – 126NADP By similarity

Sites

Active site1751Proton donor By similarity
Binding site311NADP; via amide nitrogen By similarity
Binding site941NADP; via amide nitrogen By similarity
Binding site941Substrate By similarity
Binding site1201NADP; via amide nitrogen and carbonyl oxygen By similarity
Binding site1791Substrate By similarity
Binding site1831Substrate By similarity
Binding site1931Substrate By similarity
Binding site2421Substrate By similarity
Binding site2451Substrate By similarity
Binding site2571NADP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9KPQ9 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: A594D8EAFEE5EEAD

FASTA29632,201
        10         20         30         40         50         60 
MNIVVLGPGA VGSLWALHLH SAGHQVALWS RQAQPTITLQ LDEEAPISFR NQNLDTLIHA 

        70         80         90        100        110        120 
DLLLITVKAW QVEAALQPLL PHLNRETILL FMHNGMGAVE AISESLTHFP VLFATTTHGA 

       130        140        150        160        170        180 
LKATLNQVSH TGFGQTQVGP FNALGARCDF IADVFNHALA PVTWNPEIQQ ALWRKLAVNC 

       190        200        210        220        230        240 
AINPLTAIHQ CANGALVAPE FTPIITAILD EVTAVMQAEA ISGEAEALRD GVYQVIQATA 

       250        260        270        280        290 
ANLSSMHQDV FHRRPTEIDF ITGYVVRKGE QHGIATPVNS ALYQQIKTLE QSWSKA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE003852 Genomic DNA. Translation: AAF95451.1.
PIRD82092.
RefSeqNP_231938.1. NC_002505.1.

3D structure databases

ProteinModelPortalQ9KPQ9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243277.VC2307.

Protocols and materials databases

DNASU2613103.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF95451; AAF95451; VC_2307.
GeneID2613103.
KEGGvch:VC2307.
PATRIC20083649. VBIVibCho83274_2199.

Phylogenomic databases

eggNOGCOG1893.
KOK00077.
OMAIDDDRGE.
OrthoDBEOG68SVW3.
ProtClustDBPRK06522.

Enzyme and pathway databases

BioCycVCHO:VC2307-MONOMER.
UniPathwayUPA00028; UER00004.

Family and domain databases

Gene3D1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProIPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013752. ApbA_C.
IPR013332. ApbA_N.
IPR013328. DH_multihelical.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMSSF48179. SSF48179. 1 hit.
TIGRFAMsTIGR00745. apbA_panE. 1 hit.
ProtoNetSearch...

Entry information

Entry namePANE_VIBCH
AccessionPrimary (citable) accession number: Q9KPQ9
Entry history
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: October 1, 2000
Last modified: December 11, 2013
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways