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Protein

2-dehydropantoate 2-reductase

Gene

panE

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid.

Catalytic activityi

(R)-pantoate + NADP+ = 2-dehydropantoate + NADPH.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei31 – 311NADP; via amide nitrogenBy similarity
Binding sitei94 – 941NADP; via amide nitrogenBy similarity
Binding sitei94 – 941SubstrateBy similarity
Binding sitei120 – 1201NADP; via amide nitrogen and carbonyl oxygenBy similarity
Active sitei175 – 1751Proton donorBy similarity
Binding sitei179 – 1791SubstrateBy similarity
Binding sitei183 – 1831SubstrateBy similarity
Binding sitei193 – 1931SubstrateBy similarity
Binding sitei242 – 2421SubstrateBy similarity
Binding sitei245 – 2451SubstrateBy similarity
Binding sitei257 – 2571NADPBy similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi7 – 126NADPBy similarity

GO - Molecular functioni

  1. 2-dehydropantoate 2-reductase activity Source: TIGR
  2. NADP binding Source: InterPro

GO - Biological processi

  1. pantothenate biosynthetic process Source: TIGR
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Pantothenate biosynthesis

Keywords - Ligandi

NADP

Enzyme and pathway databases

BioCyciVCHO:VC2307-MONOMER.
UniPathwayiUPA00028; UER00004.

Names & Taxonomyi

Protein namesi
Recommended name:
2-dehydropantoate 2-reductase (EC:1.1.1.169)
Alternative name(s):
Ketopantoate reductase
Short name:
KPA reductase
Short name:
KPR
Gene namesi
Name:panE
Ordered Locus Names:VC_2307
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584: Chromosome 1

Subcellular locationi

Cytoplasm Curated

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 2962962-dehydropantoate 2-reductasePRO_0000157306Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243277.VC2307.

Structurei

3D structure databases

ProteinModelPortaliQ9KPQ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ketopantoate reductase family.Curated

Phylogenomic databases

eggNOGiCOG1893.
KOiK00077.
OMAiWKWAKAI.
OrthoDBiEOG68SVW3.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00745. apbA_panE. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9KPQ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIVVLGPGA VGSLWALHLH SAGHQVALWS RQAQPTITLQ LDEEAPISFR
60 70 80 90 100
NQNLDTLIHA DLLLITVKAW QVEAALQPLL PHLNRETILL FMHNGMGAVE
110 120 130 140 150
AISESLTHFP VLFATTTHGA LKATLNQVSH TGFGQTQVGP FNALGARCDF
160 170 180 190 200
IADVFNHALA PVTWNPEIQQ ALWRKLAVNC AINPLTAIHQ CANGALVAPE
210 220 230 240 250
FTPIITAILD EVTAVMQAEA ISGEAEALRD GVYQVIQATA ANLSSMHQDV
260 270 280 290
FHRRPTEIDF ITGYVVRKGE QHGIATPVNS ALYQQIKTLE QSWSKA
Length:296
Mass (Da):32,201
Last modified:October 1, 2000 - v1
Checksum:iA594D8EAFEE5EEAD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF95451.1.
PIRiD82092.
RefSeqiNP_231938.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF95451; AAF95451; VC_2307.
GeneIDi2613103.
KEGGivch:VC2307.
PATRICi20083649. VBIVibCho83274_2199.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF95451.1.
PIRiD82092.
RefSeqiNP_231938.1. NC_002505.1.

3D structure databases

ProteinModelPortaliQ9KPQ9.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243277.VC2307.

Protocols and materials databases

DNASUi2613103.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF95451; AAF95451; VC_2307.
GeneIDi2613103.
KEGGivch:VC2307.
PATRICi20083649. VBIVibCho83274_2199.

Phylogenomic databases

eggNOGiCOG1893.
KOiK00077.
OMAiWKWAKAI.
OrthoDBiEOG68SVW3.

Enzyme and pathway databases

UniPathwayiUPA00028; UER00004.
BioCyciVCHO:VC2307-MONOMER.

Family and domain databases

Gene3Di1.10.1040.10. 1 hit.
3.40.50.720. 1 hit.
InterProiIPR008927. 6-PGluconate_DH_C-like.
IPR003710. ApbA.
IPR013328. DH_multihelical.
IPR013752. KPA_reductase.
IPR013332. KPR_N.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PfamiPF02558. ApbA. 1 hit.
PF08546. ApbA_C. 1 hit.
[Graphical view]
SUPFAMiSSF48179. SSF48179. 1 hit.
TIGRFAMsiTIGR00745. apbA_panE. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.

Entry informationi

Entry nameiPANE_VIBCH
AccessioniPrimary (citable) accession number: Q9KPQ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 21, 2002
Last sequence update: October 1, 2000
Last modified: January 7, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.