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Protein

Membrane-bound lytic murein transglycosylase A

Gene

mltA

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. Degrades murein glycan strands and insoluble, high-molecular weight murein sacculi (By similarity).By similarity

Catalytic activityi

Exolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.

GO - Molecular functioni

  • catalytic activity Source: TIGR
  • hydrolase activity, hydrolyzing O-glycosyl compounds Source: InterPro
  • lyase activity Source: UniProtKB-KW

GO - Biological processi

  • cell wall organization Source: UniProtKB-KW
  • peptidoglycan catabolic process Source: TIGR
  • peptidoglycan turnover Source: InterPro

Keywordsi

Molecular functionLyase
Biological processCell wall biogenesis/degradation

Enzyme and pathway databases

BioCyciVCHO:VC2312-MONOMER.

Protein family/group databases

CAZyiGH102. Glycoside Hydrolase Family 102.

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-bound lytic murein transglycosylase A (EC:4.2.2.n1)
Alternative name(s):
Murein hydrolase A
Gene namesi
Name:mltA
Ordered Locus Names:VC_2312
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000000584 Componenti: Chromosome 1

Subcellular locationi

  • Cell outer membrane By similarity; Lipid-anchor PROSITE-ProRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16CuratedAdd BLAST16
ChainiPRO_000003278317 – 368Membrane-bound lytic murein transglycosylase AAdd BLAST352

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi17N-palmitoyl cysteineCurated1
Lipidationi17S-diacylglycerol cysteineCurated1

Keywords - PTMi

Lipoprotein, Palmitate

Interactioni

Protein-protein interaction databases

STRINGi243277.VC2312.

Structurei

3D structure databases

ProteinModelPortaliQ9KPQ4.
SMRiQ9KPQ4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG4105CA3. Bacteria.
COG2821. LUCA.
KOiK08304.
OMAiDQNGHPY.

Family and domain databases

CDDicd14485. mltA_like_LT_A. 1 hit.
InterProiView protein in InterPro
IPR010611. 3D_dom.
IPR034654. MltA_3D.
IPR005300. MltA_B.
IPR009009. RlpA-like_DPBB.
PfamiView protein in Pfam
PF06725. 3D. 1 hit.
PF03562. MltA. 1 hit.
SMARTiView protein in SMART
SM00925. MltA. 1 hit.
SUPFAMiSSF50685. SSF50685. 1 hit.
PROSITEiView protein in PROSITE
PS51257. PROKAR_LIPOPROTEIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q9KPQ4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKRLLSLAS LALLFGCAQQ PNDRAQQYQQ QTFPHILNRA DVVESNKPRD
60 70 80 90 100
YTEFSKQSEL VVQGSASMAK IYRPLYEQLN EWVLQSGDPA TLAQFGIQAA
110 120 130 140 150
QLGGGDKQGN VLFTGYFSPV IELRHQPDSV FKYPVYGLPK CNKNCPTRAE
160 170 180 190 200
IYQGALDGQG LELGYAENLI DPFIMEVQGS GFVHFGDDDT LEYFAYAGKN
210 220 230 240 250
NKAYVSIGKV LIERGLVERE KMSLKAIKDW VLANDEATVR ELLEENPSFV
260 270 280 290 300
FFKPSAAAPV KGSAGIPLLP MASVAGDRSI LPMGTPILAE VPLLNADGTW
310 320 330 340 350
SGAHQLRLLI VLDTGGAVKQ NHLDLYHGMG PRAGLEAGHY KHFGRVWKLG
360
LENSPTQAPW ALPPEKQQ
Length:368
Mass (Da):40,458
Last modified:October 1, 2000 - v1
Checksum:iC1341A9D21A41DBB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF95456.1.
PIRiA82093.
RefSeqiNP_231943.1. NC_002505.1.
WP_000044381.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF95456; AAF95456; VC_2312.
GeneIDi2613108.
KEGGivch:VC2312.
PATRICifig|243277.26.peg.2204.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiMLTA_VIBCH
AccessioniPrimary (citable) accession number: Q9KPQ4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: October 1, 2000
Last modified: June 7, 2017
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome