Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Amino-acid acetyltransferase

Gene

argA

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate.

Pathwayi: L-arginine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate.
Proteins known to be involved in the 4 steps of the subpathway in this organism are:
  1. Amino-acid acetyltransferase (argA)
  2. Acetylglutamate kinase (argB)
  3. N-acetyl-gamma-glutamyl-phosphate reductase (argC)
  4. Acetylornithine aminotransferase (argD)
This subpathway is part of the pathway L-arginine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes N(2)-acetyl-L-ornithine from L-glutamate, the pathway L-arginine biosynthesis and in Amino-acid biosynthesis.

GO - Molecular functioni

  • acetyl-CoA:L-glutamate N-acetyltransferase activity Source: TIGR

GO - Biological processi

  • arginine biosynthetic process Source: TIGR
Complete GO annotation...

Keywords - Molecular functioni

Acyltransferase, Transferase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00068; UER00106.

Names & Taxonomyi

Protein namesi
Recommended name:
Amino-acid acetyltransferase (EC:2.3.1.1)
Alternative name(s):
N-acetylglutamate synthase
Short name:
AGS
Short name:
NAGS
Gene namesi
Name:argA
Ordered Locus Names:VC_2316
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000000584 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 445445Amino-acid acetyltransferasePRO_0000186808Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243277.VC2316.

Structurei

3D structure databases

ProteinModelPortaliQ9KPQ0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini299 – 445147N-acetyltransferaseAdd
BLAST

Sequence similaritiesi

Contains 1 N-acetyltransferase domain.Curated

Phylogenomic databases

eggNOGiENOG4107QZM. Bacteria.
COG0548. LUCA.
COG1246. LUCA.
KOiK14682.
OMAiKQALYNY.

Family and domain databases

CDDicd04237. AAK_NAGS-ABP. 1 hit.
Gene3Di3.40.1160.10. 1 hit.
3.40.630.30. 1 hit.
HAMAPiMF_01105. N_acetyl_glu_synth. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR001048. Asp/Glu/Uridylate_kinase.
IPR000182. GNAT_dom.
IPR033719. NAGS_kin.
IPR010167. NH2A_AcTrfase.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000423. ArgA. 1 hit.
SUPFAMiSSF53633. SSF53633. 1 hit.
SSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR01890. N-Ac-Glu-synth. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KPQ0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKIRSTALVK GFRQSAPYVN AHRGKTMVVM LGGEAIADKN FPNIISDIAL
60 70 80 90 100
LHSLGVKVVL VHGARPQINQ ILEKNQRDTP YHKGVRITDE SSLGLVMQAA
110 120 130 140 150
GQLQHAITAR LSMSLNNTPM AGTQLNVVSG NFIISQPLGI DEGVDYCHSG
160 170 180 190 200
RIRRIDVEGI NRMLDLGSIV LLGPIASSVT GECFNLLSEE VATQVAIKLK
210 220 230 240 250
ADKLIGFCPQ QGIIDTKGNA IAELFPSDVE RLVKSMEQEC APDDEECFST
260 270 280 290 300
MRFLRAALKA CRAGVPRSHL VSYKEDGALI QELFSFDGIG TQIVMASAEQ
310 320 330 340 350
IRQATIDDIG GIFDLIRPLE EQGILVRRSR EQLEQEIHKF TIIDKDGLVI
360 370 380 390 400
GCSALYPYPE ERMAEMACVA IHPEYRDGHR GLHLLVHSKH QAKQMGIRHL
410 420 430 440
FVLTTHSTHW FREQGFNEVD VEALPMAKKS LYNYQRRSKI LMLQL
Length:445
Mass (Da):49,443
Last modified:February 12, 2003 - v2
Checksum:iA3C1B1EE0591F182
GO

Sequence cautioni

The sequence AAF95460 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF95460.1. Different initiation.
PIRiE82093.
RefSeqiNP_231947.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF95460; AAF95460; VC_2316.
GeneIDi2613112.
KEGGivch:VC2316.
PATRICi20083665. VBIVibCho83274_2207.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF95460.1. Different initiation.
PIRiE82093.
RefSeqiNP_231947.1. NC_002505.1.

3D structure databases

ProteinModelPortaliQ9KPQ0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243277.VC2316.

Protocols and materials databases

DNASUi2613112.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF95460; AAF95460; VC_2316.
GeneIDi2613112.
KEGGivch:VC2316.
PATRICi20083665. VBIVibCho83274_2207.

Phylogenomic databases

eggNOGiENOG4107QZM. Bacteria.
COG0548. LUCA.
COG1246. LUCA.
KOiK14682.
OMAiKQALYNY.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00106.

Family and domain databases

CDDicd04237. AAK_NAGS-ABP. 1 hit.
Gene3Di3.40.1160.10. 1 hit.
3.40.630.30. 1 hit.
HAMAPiMF_01105. N_acetyl_glu_synth. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR001048. Asp/Glu/Uridylate_kinase.
IPR000182. GNAT_dom.
IPR033719. NAGS_kin.
IPR010167. NH2A_AcTrfase.
[Graphical view]
PfamiPF00696. AA_kinase. 1 hit.
[Graphical view]
PIRSFiPIRSF000423. ArgA. 1 hit.
SUPFAMiSSF53633. SSF53633. 1 hit.
SSF55729. SSF55729. 1 hit.
TIGRFAMsiTIGR01890. N-Ac-Glu-synth. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARGA_VIBCH
AccessioniPrimary (citable) accession number: Q9KPQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 12, 2003
Last sequence update: February 12, 2003
Last modified: September 7, 2016
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.