Q9KPQ0 (ARGA_VIBCH) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Amino-acid acetyltransferase
EC=2.3.1.1

Alternative name(s):
N-acetylglutamate synthase
Short name=AGS
Short name=NAGS

Gene names

Name:	argA
Ordered Locus Names:	VC_2316

Organism

Vibrio cholerae

Taxonomic identifier

666 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	445 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate. HAMAP MF_01105
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 1/4. HAMAP MF_01105
Subcellular location	Cytoplasm Probable HAMAP MF_01105.
Sequence similarities	Belongs to the acetyltransferase family. ArgA subfamily. Contains 1 N-acetyltransferase domain.
Sequence caution	The sequence AAF95460.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Acyltransferase Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	acetyl-CoA:L-glutamate N-acetyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 445	445	Amino-acid acetyltransferase HAMAP MF_01105		PRO_0000186808
Regions
	Domain	299 – 445	147	N-acetyltransferase

Sequences

	Sequence		Length	Mass (Da)
	Q9KPQ0 [UniParc]. Last modified February 12, 2003. Version 2. Checksum: A3C1B1EE0591F182	FASTA	445	49,443
	10 20 30 40 50 60 MKIRSTALVK GFRQSAPYVN AHRGKTMVVM LGGEAIADKN FPNIISDIAL LHSLGVKVVL 70 80 90 100 110 120 VHGARPQINQ ILEKNQRDTP YHKGVRITDE SSLGLVMQAA GQLQHAITAR LSMSLNNTPM 130 140 150 160 170 180 AGTQLNVVSG NFIISQPLGI DEGVDYCHSG RIRRIDVEGI NRMLDLGSIV LLGPIASSVT 190 200 210 220 230 240 GECFNLLSEE VATQVAIKLK ADKLIGFCPQ QGIIDTKGNA IAELFPSDVE RLVKSMEQEC 250 260 270 280 290 300 APDDEECFST MRFLRAALKA CRAGVPRSHL VSYKEDGALI QELFSFDGIG TQIVMASAEQ 310 320 330 340 350 360 IRQATIDDIG GIFDLIRPLE EQGILVRRSR EQLEQEIHKF TIIDKDGLVI GCSALYPYPE 370 380 390 400 410 420 ERMAEMACVA IHPEYRDGHR GLHLLVHSKH QAKQMGIRHL FVLTTHSTHW FREQGFNEVD 430 440 VEALPMAKKS LYNYQRRSKI LMLQL

References

[1]

"DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae." Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R., Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D., Vamathevan J.J., Bass S. , Qin H., Dragoi I., Sellers P., McDonald L.A., Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L., Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M. Nature 406:477-483(2000) [PubMed: 10952301] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 39315 / El Tor Inaba N16961 / Serotype O1.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE003852 Genomic DNA. Translation: AAF95460.1. Different initiation.
PIR	E82093.
RefSeq	NP_231947.1. NC_002505.1.
3D structure databases
ProteinModelPortal	Q9KPQ0.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	2613112.
GenomeReviews	Gene locus VC_2316 in contig AE003852_GR.
KEGG	vch:VC2316.
PATRIC	20083665. VBIVibCho83274_2207.
TIGR	VC_2316.
Phylogenomic databases
HOGENOM	HBG545264.
OMA	AFNLAME.
PhylomeDB	Q9KPQ0.
ProtClustDB	PRK05279.
Family and domain databases
HAMAP	MF_01105. N-acetyl_glu_synth. [Tree]
InterPro	IPR000182. AcTrfase_GCN5-related_dom. IPR016181. Acyl_CoA_acyltransferase. IPR001048. Asp/Glu/Uridylate_kinase. IPR010167. NH2A_AcTrfase_ArgA. [Graphical view]
Gene3D	G3DSA:3.40.1160.10. Aa_kinase. 1 hit. G3DSA:3.40.630.30. Acyl_CoA_acyltransferase. 1 hit.
KO	K14682.
Pfam	PF00696. AA_kinase. 1 hit. PF00583. Acetyltransf_1. 1 hit. [Graphical view]
PIRSF	PIRSF000423. ArgA. 1 hit.
SUPFAM	SSF53633. Aa_kinase. 1 hit. SSF55729. Acyl_CoA_acyltransferase. 1 hit.
TIGRFAMs	TIGR01890. N-Ac-Glu-synth. 1 hit.
PROSITE	PS51186. GNAT. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGA_VIBCH

Accession

Primary (citable) accession number: Q9KPQ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 12, 2003
Last sequence update:	February 12, 2003
Last modified:	January 25, 2012
This is version 58 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program