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Q9KPL8

- TYPH_VIBCH

UniProt

Q9KPL8 - TYPH_VIBCH

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Protein

Thymidine phosphorylase

Gene

deoA

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis.UniRule annotation

Catalytic activityi

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. phosphorylase activity Source: InterPro
  2. pyrimidine-nucleoside phosphorylase activity Source: InterPro
  3. thymidine phosphorylase activity Source: TIGR

GO - Biological processi

  1. nucleobase-containing compound metabolic process Source: TIGR
  2. pyrimidine nucleobase metabolic process Source: InterPro
  3. pyrimidine nucleoside metabolic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

UniPathwayiUPA00578; UER00638.

Names & Taxonomyi

Protein namesi
Recommended name:
Thymidine phosphorylaseUniRule annotation (EC:2.4.2.4UniRule annotation)
Alternative name(s):
TdRPaseUniRule annotation
Gene namesi
Name:deoAUniRule annotation
Ordered Locus Names:VC_2349
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584: Chromosome 1

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 448448Thymidine phosphorylasePRO_0000059070Add
BLAST

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi243277.VC2349.

Structurei

3D structure databases

ProteinModelPortaliQ9KPL8.
SMRiQ9KPL8. Positions 8-443.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0213.
KOiK00758.
OMAiNVGHTLE.
OrthoDBiEOG61ZTGG.

Family and domain databases

Gene3Di3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPiMF_01628. Thymid_phosp.
InterProiIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013465. Thymidine_Pase.
[Graphical view]
PANTHERiPTHR10515. PTHR10515. 1 hit.
PfamiPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFiPIRSF000478. TP_PyNP. 1 hit.
SMARTiSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMiSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsiTIGR02643. T_phosphoryl. 1 hit.
TIGR02644. Y_phosphoryl. 1 hit.
PROSITEiPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KPL8-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSLSQAKYLP QEIIRRKRDG EVLTNDEINF FIQGVANNTV SEGQIAAFAM
60 70 80 90 100
AIFFREMTMP ERIALTCAMR DSGMVIDWSH MNFDGPIVDK HSTGGVGDVT
110 120 130 140 150
SLMLGPMVAA CGGYVPMISG RGLGHTGGTL DKLEAIPGYN ITPTNDVFGK
160 170 180 190 200
VTKQAGVAII GQTGDLAPAD KRVYATRDIT ATVDNISLIT ASILSKKLAA
210 220 230 240 250
GLESLVMDVK VGSGAFMPTY EASEELAKSI VAVANGAGTN TTAILTDMNQ
260 270 280 290 300
VLASSAGNAV EVREAVRFLT GEYRNPRLLE VTMASCAEML VLGKLAKDTA
310 320 330 340 350
QAREKLQAVL DNGQAADRFG KMVAGLGGPS DFVENYDKYL AKAEIIRPVY
360 370 380 390 400
AQQSGVISAM DTRAIGMAVV GMGGGRRVAT DRIDYAVGFD QFIRLGEIAD
410 420 430 440
SNKPLAMIHA RNEEQWQQAA NALQSAIKVG GDYLPTPDVY RQIRAQDV
Length:448
Mass (Da):47,843
Last modified:January 10, 2006 - v2
Checksum:i7955ABB95C401F62
GO

Sequence cautioni

The sequence AAF95492.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF95492.1. Different initiation.
PIRiE82087.
RefSeqiNP_231979.2. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF95492; AAF95492; VC_2349.
GeneIDi2613145.
KEGGivch:VC2349.
PATRICi20083723. VBIVibCho83274_2236.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF95492.1 . Different initiation.
PIRi E82087.
RefSeqi NP_231979.2. NC_002505.1.

3D structure databases

ProteinModelPortali Q9KPL8.
SMRi Q9KPL8. Positions 8-443.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243277.VC2349.

Protocols and materials databases

DNASUi 2613145.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF95492 ; AAF95492 ; VC_2349 .
GeneIDi 2613145.
KEGGi vch:VC2349.
PATRICi 20083723. VBIVibCho83274_2236.

Phylogenomic databases

eggNOGi COG0213.
KOi K00758.
OMAi NVGHTLE.
OrthoDBi EOG61ZTGG.

Enzyme and pathway databases

UniPathwayi UPA00578 ; UER00638 .

Family and domain databases

Gene3Di 3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPi MF_01628. Thymid_phosp.
InterProi IPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013465. Thymidine_Pase.
[Graphical view ]
PANTHERi PTHR10515. PTHR10515. 1 hit.
Pfami PF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view ]
PIRSFi PIRSF000478. TP_PyNP. 1 hit.
SMARTi SM00941. PYNP_C. 1 hit.
[Graphical view ]
SUPFAMi SSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsi TIGR02643. T_phosphoryl. 1 hit.
TIGR02644. Y_phosphoryl. 1 hit.
PROSITEi PS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.

Entry informationi

Entry nameiTYPH_VIBCH
AccessioniPrimary (citable) accession number: Q9KPL8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: October 1, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3