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Q9KPL8 (TYPH_VIBCH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine phosphorylase

EC=2.4.2.4
Alternative name(s):
TdRPase
Gene names
Name:deoA
Ordered Locus Names:VC_2349
OrganismVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) [Reference proteome] [HAMAP]
Taxonomic identifier243277 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length448 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The enzymes which catalyze the reversible phosphorolysis of pyrimidine nucleosides are involved in the degradation of these compounds and in their utilization as carbon and energy sources, or in the rescue of pyrimidine bases for nucleotide synthesis By similarity. HAMAP-Rule MF_01628

Catalytic activity

Thymidine + phosphate = thymine + 2-deoxy-alpha-D-ribose 1-phosphate. HAMAP-Rule MF_01628

Pathway

Pyrimidine metabolism; dTMP biosynthesis via salvage pathway; dTMP from thymine: step 1/2. HAMAP-Rule MF_01628

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01628

Sequence similarities

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.

Sequence caution

The sequence AAF95492.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 448448Thymidine phosphorylase HAMAP-Rule MF_01628
PRO_0000059070

Sequences

Sequence LengthMass (Da)Tools
Q9KPL8 [UniParc].

Last modified January 10, 2006. Version 2.
Checksum: 7955ABB95C401F62

FASTA44847,843
        10         20         30         40         50         60 
MSLSQAKYLP QEIIRRKRDG EVLTNDEINF FIQGVANNTV SEGQIAAFAM AIFFREMTMP 

        70         80         90        100        110        120 
ERIALTCAMR DSGMVIDWSH MNFDGPIVDK HSTGGVGDVT SLMLGPMVAA CGGYVPMISG 

       130        140        150        160        170        180 
RGLGHTGGTL DKLEAIPGYN ITPTNDVFGK VTKQAGVAII GQTGDLAPAD KRVYATRDIT 

       190        200        210        220        230        240 
ATVDNISLIT ASILSKKLAA GLESLVMDVK VGSGAFMPTY EASEELAKSI VAVANGAGTN 

       250        260        270        280        290        300 
TTAILTDMNQ VLASSAGNAV EVREAVRFLT GEYRNPRLLE VTMASCAEML VLGKLAKDTA 

       310        320        330        340        350        360 
QAREKLQAVL DNGQAADRFG KMVAGLGGPS DFVENYDKYL AKAEIIRPVY AQQSGVISAM 

       370        380        390        400        410        420 
DTRAIGMAVV GMGGGRRVAT DRIDYAVGFD QFIRLGEIAD SNKPLAMIHA RNEEQWQQAA 

       430        440 
NALQSAIKVG GDYLPTPDVY RQIRAQDV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE003852 Genomic DNA. Translation: AAF95492.1. Different initiation.
PIRE82087.
RefSeqNP_231979.2. NC_002505.1.

3D structure databases

ProteinModelPortalQ9KPL8.
SMRQ9KPL8. Positions 8-443.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243277.VC2349.

Protocols and materials databases

DNASU2613145.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF95492; AAF95492; VC_2349.
GeneID2613145.
KEGGvch:VC2349.
PATRIC20083723. VBIVibCho83274_2236.

Phylogenomic databases

eggNOGCOG0213.
KOK00758.
OMANVGHTLE.
OrthoDBEOG61ZTGG.

Enzyme and pathway databases

UniPathwayUPA00578; UER00638.

Family and domain databases

Gene3D3.40.1030.10. 1 hit.
3.90.1170.30. 1 hit.
HAMAPMF_01628. Thymid_phosp.
InterProIPR000312. Glycosyl_Trfase_fam3.
IPR017459. Glycosyl_Trfase_fam3_N_dom.
IPR013102. PYNP_C.
IPR018090. Pyrmidine_PPas_bac/euk.
IPR000053. Pyrmidine_PPase.
IPR017872. Pyrmidine_PPase_CS.
IPR013465. Thymidine_Pase.
[Graphical view]
PANTHERPTHR10515. PTHR10515. 1 hit.
PfamPF02885. Glycos_trans_3N. 1 hit.
PF00591. Glycos_transf_3. 1 hit.
PF07831. PYNP_C. 1 hit.
[Graphical view]
PIRSFPIRSF000478. TP_PyNP. 1 hit.
SMARTSM00941. PYNP_C. 1 hit.
[Graphical view]
SUPFAMSSF47648. SSF47648. 1 hit.
SSF52418. SSF52418. 1 hit.
SSF54680. SSF54680. 1 hit.
TIGRFAMsTIGR02643. T_phosphoryl. 1 hit.
TIGR02644. Y_phosphoryl. 1 hit.
PROSITEPS00647. THYMID_PHOSPHORYLASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameTYPH_VIBCH
AccessionPrimary (citable) accession number: Q9KPL8
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: January 10, 2006
Last modified: May 14, 2014
This is version 82 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways