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Reviewed, UniProtKB/Swiss-Prot Q9KPA4 (NADB_VIBCH)

Last modified June 16, 2009. Version 49. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    L-aspartate oxidase
      Short name=LASPO
    EC=1.4.3.16
Alternative name(s):
    Quinolinate synthetase B
Gene names
Name: nadB
Ordered Locus Names: VC_2469
OrganismVibrio cholerae [Complete proteome] [HAMAP]
Taxonomic identifier666 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

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Protein attributes

Sequence length535 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Function

Catalyzes the oxidation of L-aspartate to iminoaspartate.

Catalytic activity

L-aspartate + O2 = iminosuccinate + H2O2.

Cofactor

FAD.

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; iminoaspartate from L-aspartate (oxidase route): step 1/1.

Subcellular location

Cytoplasm By similarity.

Sequence similarities

Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.

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Ontologies

Keywords
   Biological processPyridine nucleotide biosynthesis
   Cellular componentCytoplasm
   LigandFAD
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processNAD biosynthetic process

Inferred from electronic annotation. Source: InterPro

oxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionL-aspartate oxidase activity

Inferred from electronic annotation. Source: EC

electron carrier activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 535535L-aspartate oxidase
PRO_0000184403

Regions

Nucleotide binding12 – 2615FAD Potential

Sites

Active site2441 By similarity
Active site2631 By similarity

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Sequences

Sequence LengthMass (Da)Tools
Q9KPA4-1 [UniParc].

Last modified August 30, 2002. Version 2.
Checksum: 0CC31E7FEEF7A601

FASTA53559,873
        10         20         30         40         50         60 
MNADREHQCD VLVIGSGAAG LSLALQVAQY GKVIVLSKGP RSEGATFYAQ GGIAAVFDES 

        70         80         90        100        110        120 
DSIESHVQDT LIAGAGICDE QTVRFIAEHA KECVQWLIDG GVPFDKEEDS DNDHPRYHLT 

       130        140        150        160        170        180 
REGGHSHRRI LHAADATGMA MQTSLQDNAH NHPNITVLER HNALDLITED KIGGDANKVV 

       190        200        210        220        230        240 
GAYVWNRNAE HVETIRAKFV VLATGGASKV YQYTSNPDVS SGDGIAMAWR AGCRVANLEF 

       250        260        270        280        290        300 
NQFHPTCLYH PEARNFLLTE ALRGEGAYLR RPDGSRFMPD FDERAELAPR DIVARAIDFE 

       310        320        330        340        350        360 
MKRLGADCMY LDISHKPADF IEKHFPTIYS RLMDLGIDMT KEPIPIVPAA HYTCGGVMVN 

       370        380        390        400        410        420 
PQGQTDLKQL YAIGEVSYTG LHGANRMASN SLLECVVYAW SASQDIIAQL PNASMPESLP 

       430        440        450        460        470        480 
AWDESQVTCS DEEVVLQHNW HELRLFMWDY MGIVRTNKRL ERAMRRIQLL QQETHEYYSN 

       490        500        510        520        530 
FRVSNNLLEM RNLLQVAELM VRCAMQRKES RGLHYTLDYP DQLAESGPTI LVPEK

« Hide

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Cross-references

Sequence databases

AE003852 Genomic DNA. Translation: AAF95611.1. Different initiation.
PIRB82074.
RefSeqNP_232098.1.

3D structure databases

HSSPHSSP built from PDB template 1CHU based on UniProtKB P10902.
SMRQ9KPA4. Positions 6-533.
ModBaseSearch...

Genome annotation databases

GeneID2613011.
GenomeReviewsGene locus VC_2469 in contig AE003852_GR.
KEGGvch:VC2469.
TIGRVC_2469.

Phylogenomic databases

HOGENOMQ9KPA4.

Enzyme and pathway databases

BRENDA1.4.3.16. 19019.

Family and domain databases

InterProIPR003953. FAD_bind2_N.
IPR013027. FAD_pyr_nucl-diS_OxRdtase.
IPR004112. Fum_Rdtase/Succ_DH_flav_C.
IPR005288. NadB.
[Graphical view]
PfamPF00890. FAD_binding_2. 1 hit.
PF02910. Succ_DH_flav_C. 1 hit.
[Graphical view]
PRINTSPR00368. FADPNR.
TIGRFAMsTIGR00551. nadB. 1 hit.
ProtoNetSearch...

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Entry information

Entry nameNADB_VIBCH
AccessionPrimary (citable) accession number: Q9KPA4
Entry history
Integrated into UniProtKB/Swiss-Prot: August 30, 2002
Last sequence update: August 30, 2002
Last modified: June 16, 2009
This is version 49 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents