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Protein

Ribonuclease R

Gene

rnr

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.UniRule annotation

Catalytic activityi

Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates.UniRule annotation

GO - Molecular functioni

  • 3'-5'-exoribonuclease activity Source: GO_Central
  • exoribonuclease II activity Source: UniProtKB-HAMAP
  • ribonuclease R activity Source: TIGR
  • RNA binding Source: UniProtKB-HAMAP

GO - Biological processi

  • RNA catabolic process Source: GO_Central
  • RNA phosphodiester bond hydrolysis Source: GOC
  • RNA phosphodiester bond hydrolysis, exonucleolytic Source: GOC
  • RNA processing Source: TIGR
  • rRNA processing Source: GO_Central
Complete GO annotation...

Keywords - Molecular functioni

Exonuclease, Hydrolase, Nuclease

Keywords - Ligandi

RNA-binding

Enzyme and pathway databases

BioCyciVCHO:VC2599-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease RUniRule annotation (EC:3.1.13.1UniRule annotation)
Short name:
RNase RUniRule annotation
Gene namesi
Name:rnrUniRule annotation
Ordered Locus Names:VC_2599
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000000584 Componenti: Chromosome 1

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 821821Ribonuclease RPRO_0000166415Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243277.VC2599.

Structurei

3D structure databases

ProteinModelPortaliQ9KNY1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini652 – 73382S1 motifUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the RNR ribonuclease family. RNase R subfamily.UniRule annotation
Contains 1 S1 motif domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C40. Bacteria.
COG0557. LUCA.
KOiK12573.
OMAiYRVHEGP.
OrthoDBiEOG6Q5NRD.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_01895. RNase_R.
InterProiIPR011129. Cold_shock_prot.
IPR012340. NA-bd_OB-fold.
IPR013223. RNase_B_OB_dom.
IPR022966. RNase_II/R_CS.
IPR004476. RNase_II/RNase_R.
IPR011805. RNase_R.
IPR013668. RNase_R_HTH_12.
IPR022967. S1_dom.
IPR003029. S1_domain.
[Graphical view]
PfamiPF08461. HTH_12. 1 hit.
PF08206. OB_RNB. 1 hit.
PF00575. S1. 1 hit.
[Graphical view]
SMARTiSM00357. CSP. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 4 hits.
TIGRFAMsiTIGR00358. 3_prime_RNase. 1 hit.
TIGR02063. RNase_R. 1 hit.
PROSITEiPS01175. RIBONUCLEASE_II. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KNY1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDTTHLDPF ADREADNYDN PIPSREYILE FLTQANVPMN RNDLFEALKL
60 70 80 90 100
EGEEQYEGLR RRLRAMERDG QLVFTRRQCY ALPEKLEMVK GYVIGHKDGH
110 120 130 140 150
GWVRPEGSLN KEGDILLPHH QMRTLIHGDF VLVQPSGTDK RGRKEGRLVR
160 170 180 190 200
ILEERNGQIV GRFFFEYGYS YVVPDDSRIH HDILIPNDLR AGARMGNVVV
210 220 230 240 250
IEITDRGTRN RGMMGKVVEV LGENMAPGME TQIAIRTHQI PHEWPAEVEQ
260 270 280 290 300
QVAGLTEEVP EEAKQGRVDL RALPLVTIDG EDARDFDDAV YCEAKKGGGW
310 320 330 340 350
RLWVAIADVS YYVRPDTALD KEAINRGNSV YFPSQVVPML PEVLSNGLCS
360 370 380 390 400
LNPQVDRLCM VCEMTVSETG KLSGYKHYEA VMNSHARLTY TKVHEILEGD
410 420 430 440 450
EELRERYKAL VPHLEELHKM YQVLKSARDE RGAIEFETVE TKFIFNAQRK
460 470 480 490 500
IESIEPVVRN DAHKLIEECM ILANIASASL VEKAKEAALY RVHEPPGEER
510 520 530 540 550
LTGFRDFLGE LGLDLSGGLE PSPTDYANLM KQIGERPDKE LIQTMLLRSM
560 570 580 590 600
KQAVYNADNA GHFGLALKRY AHFTSPIRRY PDLLLHRAIK YLIAKQEGRN
610 620 630 640 650
QDRWTPTGGY HYSFDDMDFY GEQCSMTERR ADDATREVSD WLKCEYMQDH
660 670 680 690 700
VGEELEGVVA NVTSFGFFVR LTELHIDGLV HISTLANDYY HYDPIGQRLV
710 720 730 740 750
GESFGAIYRL GDAVKVKVLA VNLDDRQIDF ELVETSRKLR GQGKTAKKRA
760 770 780 790 800
DEARAKAQGK KEAATKGACG KSPTKSELKP QVEATRRPDS EGRSKPKKTK
810 820
APKKRKDQAR KKSGKVRDKT K
Length:821
Mass (Da):93,334
Last modified:October 1, 2000 - v1
Checksum:iE3AE7441097447D9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF95740.1.
PIRiC82055.
RefSeqiNP_232227.1. NC_002505.1.
WP_001285863.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF95740; AAF95740; VC_2599.
GeneIDi2615616.
KEGGivch:VC2599.
PATRICi20084224. VBIVibCho83274_2478.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF95740.1.
PIRiC82055.
RefSeqiNP_232227.1. NC_002505.1.
WP_001285863.1. NC_002505.1.

3D structure databases

ProteinModelPortaliQ9KNY1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243277.VC2599.

Protocols and materials databases

DNASUi2615616.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF95740; AAF95740; VC_2599.
GeneIDi2615616.
KEGGivch:VC2599.
PATRICi20084224. VBIVibCho83274_2478.

Phylogenomic databases

eggNOGiENOG4105C40. Bacteria.
COG0557. LUCA.
KOiK12573.
OMAiYRVHEGP.
OrthoDBiEOG6Q5NRD.

Enzyme and pathway databases

BioCyciVCHO:VC2599-MONOMER.

Family and domain databases

Gene3Di2.40.50.140. 1 hit.
HAMAPiMF_01895. RNase_R.
InterProiIPR011129. Cold_shock_prot.
IPR012340. NA-bd_OB-fold.
IPR013223. RNase_B_OB_dom.
IPR022966. RNase_II/R_CS.
IPR004476. RNase_II/RNase_R.
IPR011805. RNase_R.
IPR013668. RNase_R_HTH_12.
IPR022967. S1_dom.
IPR003029. S1_domain.
[Graphical view]
PfamiPF08461. HTH_12. 1 hit.
PF08206. OB_RNB. 1 hit.
PF00575. S1. 1 hit.
[Graphical view]
SMARTiSM00357. CSP. 1 hit.
SM00316. S1. 1 hit.
[Graphical view]
SUPFAMiSSF50249. SSF50249. 4 hits.
TIGRFAMsiTIGR00358. 3_prime_RNase. 1 hit.
TIGR02063. RNase_R. 1 hit.
PROSITEiPS01175. RIBONUCLEASE_II. 1 hit.
PS50126. S1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.

Entry informationi

Entry nameiRNR_VIBCH
AccessioniPrimary (citable) accession number: Q9KNY1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: October 1, 2000
Last modified: February 17, 2016
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.