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Q9KNW4 (ASTD_VIBCH) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 65. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
N-succinylglutamate 5-semialdehyde dehydrogenase
EC=1.2.1.71
Alternative name(s):
Succinylglutamic semialdehyde dehydrogenase
Short name=SGSD
Gene names
Name:astD
Ordered Locus Names:VC_2616
OrganismVibrio cholerae
Taxonomic identifier666 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length485 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate By similarity. HAMAP MF_01174

Catalytic activity

N-succinyl-L-glutamate 5-semialdehyde + NAD+ + H2O = N-succinyl-L-glutamate + NADH. HAMAP MF_01174

Pathway

Amino-acid degradation; L-arginine degradation via AST pathway; L-glutamate and succinate from L-arginine: step 4/5. HAMAP MF_01174

Sequence similarities

Belongs to the aldehyde dehydrogenase family. AstD subfamily.

Ontologies

Keywords
   Biological processArginine metabolism
   LigandNAD
   Molecular functionOxidoreductase
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological processarginine catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionsuccinylglutamate-semialdehyde dehydrogenase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 485485N-succinylglutamate 5-semialdehyde dehydrogenase HAMAP MF_01174
PRO_0000262431

Regions

Nucleotide binding220 – 2256NAD By similarity

Sites

Active site2431 By similarity
Active site2781 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9KNW4 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 07E9FF9E24C091F2

FASTA48552,193
        10         20         30         40         50         60 
MTHWIAGEWV AGTGEKLESH TPYSHELLWQ GYSASGEQVD AAVKAARRAF LDWKKRPFAE 

        70         80         90        100        110        120 
REQKVLAFAE LVKANSEQIA QVIAKETGKP LWETRTEAAS IAGKIAISIR AYHERTGETV 

       130        140        150        160        170        180 
REAAGNQLVL RHRPLGVMAV FGPYNFPGHL PNGHIVPALL AGNTVVFKPS EQTPWTGEVL 

       190        200        210        220        230        240 
MQLWQQAGLP AGVINLVQGS KETGIALAQS RGIDGLLFTG SANTGHLLHR QFAGQPDKML 

       250        260        270        280        290        300 
ALEMGGNNPM VISEHYGDLD ATVYTIIQSA FISSGQRCTC VRRLYVPQGT KGDALLDKLV 

       310        320        330        340        350        360 
SVTAKLRIDQ PFAEPAPFMG PLVSEAAAQA ILKAQADLQA LGGKSLLEAR ALHAAFITPA 

       370        380        390        400        410        420 
IIDVTAIERL PDDEYFGPLL QVVRYQTLAQ AVELANDTRF GLSAGLVSTD DGEWDYFVEH 

       430        440        450        460        470        480 
IRAGIVNRNR QLTGASGDAP FGGPGASGNL RPSAFYAADY CAYPMASMEG DTTLLPATLS 


PGVEL

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE003852 Genomic DNA. Translation: AAF95757.1.
PIRD82054.
RefSeqNP_232244.1. NC_002505.1.

3D structure databases

ProteinModelPortalQ9KNW4.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID2615633.
GenomeReviewsGene locus VC_2616 in contig AE003852_GR.
KEGGvch:VC2616.
PATRIC20084256. VBIVibCho83274_2494.
TIGRVC_2616.

Phylogenomic databases

HOGENOMHBG752218.
OMADHIRAGI.
PhylomeDBQ9KNW4.
ProtClustDBPRK09457.

Family and domain databases

HAMAPMF_01174. Aldedh_AstD.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
IPR017649. SuccinylGlu_semiald_DH_AstD.
[Graphical view]
Gene3DG3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit.
G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KOK06447.
PANTHERPTHR11699:SF24. PTHR11699:SF24. 1 hit.
PfamPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR03240. Arg_catab_astD. 1 hit.
PROSITEPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameASTD_VIBCH
AccessionPrimary (citable) accession number: Q9KNW4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: October 1, 2000
Last modified: January 25, 2012
This is version 65 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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