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Q9KNT8

- ASSY_VIBCH

UniProt

Q9KNT8 - ASSY_VIBCH

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Protein

Argininosuccinate synthase

Gene
argG, VC_2642
Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei39 – 391ATP; via amide nitrogen and carbonyl oxygen By similarity
Binding sitei91 – 911Citrulline By similarity
Binding sitei96 – 961Citrulline By similarity
Binding sitei121 – 1211ATP; via amide nitrogen By similarity
Binding sitei123 – 1231Aspartate By similarity
Binding sitei127 – 1271Aspartate By similarity
Binding sitei127 – 1271Citrulline By similarity
Binding sitei128 – 1281Aspartate By similarity
Binding sitei131 – 1311Citrulline By similarity
Binding sitei180 – 1801Citrulline By similarity
Binding sitei189 – 1891Citrulline By similarity
Binding sitei265 – 2651Citrulline By similarity
Binding sitei277 – 2771Citrulline By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi12 – 209ATP By similarity

GO - Molecular functioni

  1. argininosuccinate synthase activity Source: TIGR
  2. ATP binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: TIGR
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVCHO:VC2642-MONOMER.
UniPathwayiUPA00068; UER00113.

Names & Taxonomyi

Protein namesi
Recommended name:
Argininosuccinate synthase (EC:6.3.4.5)
Alternative name(s):
Citrulline--aspartate ligase
Gene namesi
Name:argG
Ordered Locus Names:VC_2642
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584: Chromosome 1

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 404404Argininosuccinate synthaseUniRule annotationPRO_0000148660Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi243277.VC2642.

Structurei

3D structure databases

ProteinModelPortaliQ9KNT8.
SMRiQ9KNT8. Positions 8-401.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0137.
KOiK01940.
OMAiPECEYIR.
OrthoDBiEOG6K9QCV.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPiMF_00005. Arg_succ_synth_type1.
InterProiIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00032. argG. 1 hit.
PROSITEiPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KNT8-1 [UniParc]FASTAAdd to Basket

« Hide

MSKVQVKKVV VAYSGGLDTS VIIPWLKENY DCEVVAFVAD VGQGDEELKG    50
VEAKALSSGA SECYIVDLKE EFVKEYIYPT LKTGAYYEGK YLLGTSMARP 100
VIAKAQVEIA RKVGADALAH GCTGKGNDQV RFEGAFAALA PDLHVIAPWR 150
EWDLRSREAC LDYLAERNIP CAASLTKIYS RDANAWHVST EGGVLESTWN 200
APNEDCWVWT VDPEQAPNEA EYVTLQVAHG EVVAVDGEAM TPYNALLYLN 250
QKGAKHGVGR IDIVENRLVG MKSRGCYETP GGTIIMEALR AVEQLVLDKT 300
SFEFREELGI KASHLVYDGR WFTPLRQAVF AAADELAKDV NGEVVIKLYK 350
GQAVATQKRS ANSLYSEDFA TFGADEVYDH SHAGGFIRLY SLSSRIRALS 400
QNKQ 404
Length:404
Mass (Da):44,465
Last modified:October 1, 2000 - v1
Checksum:iA65C73B442B5AF82
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003852 Genomic DNA. Translation: AAF95783.1.
PIRiA82052.
RefSeqiNP_232270.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF95783; AAF95783; VC_2642.
GeneIDi2615659.
KEGGivch:VC2642.
PATRICi20084308. VBIVibCho83274_2520.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003852 Genomic DNA. Translation: AAF95783.1 .
PIRi A82052.
RefSeqi NP_232270.1. NC_002505.1.

3D structure databases

ProteinModelPortali Q9KNT8.
SMRi Q9KNT8. Positions 8-401.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243277.VC2642.

Protocols and materials databases

DNASUi 2615659.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF95783 ; AAF95783 ; VC_2642 .
GeneIDi 2615659.
KEGGi vch:VC2642.
PATRICi 20084308. VBIVibCho83274_2520.

Phylogenomic databases

eggNOGi COG0137.
KOi K01940.
OMAi PECEYIR.
OrthoDBi EOG6K9QCV.

Enzyme and pathway databases

UniPathwayi UPA00068 ; UER00113 .
BioCyci VCHO:VC2642-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPi MF_00005. Arg_succ_synth_type1.
InterProi IPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF00764. Arginosuc_synth. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00032. argG. 1 hit.
PROSITEi PS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.

Entry informationi

Entry nameiASSY_VIBCH
AccessioniPrimary (citable) accession number: Q9KNT8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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