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Protein

Acetylornithine deacetylase

Gene

argE

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

N(2)-acetyl-L-ornithine + H2O = acetate + L-ornithine.

Cofactori

Protein has several cofactor binding sites:
  • Zn2+By similarity, Co2+By similarityNote: Binds 2 Zn(2+) or Co2+ ions per subunit.By similarity
  • glutathioneBy similarity

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi76 – 761Cobalt or zinc 1By similarity
Active sitei78 – 781By similarity
Metal bindingi108 – 1081Cobalt or zinc 1By similarity
Metal bindingi108 – 1081Cobalt or zinc 2By similarity
Active sitei140 – 1401Proton acceptorBy similarity
Metal bindingi141 – 1411Cobalt or zinc 2By similarity
Metal bindingi165 – 1651Cobalt or zinc 1By similarity
Metal bindingi351 – 3511Cobalt or zinc 2By similarity

GO - Molecular functioni

  1. acetylornithine deacetylase activity Source: TIGR
  2. cobalt ion binding Source: InterPro
  3. metallopeptidase activity Source: InterPro
  4. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. arginine biosynthetic process Source: TIGR
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Amino-acid biosynthesis, Arginine biosynthesis

Keywords - Ligandi

Cobalt, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciVCHO:VC2645-MONOMER.
UniPathwayiUPA00068; UER00110.

Protein family/group databases

MEROPSiM20.974.

Names & Taxonomyi

Protein namesi
Recommended name:
Acetylornithine deacetylase (EC:3.5.1.16)
Short name:
AO
Short name:
Acetylornithinase
Alternative name(s):
N-acetylornithinase
Short name:
NAO
Gene namesi
Name:argE
Ordered Locus Names:VC_2645
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584 Componenti: Chromosome 1

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 378378Acetylornithine deacetylasePRO_0000185251Add
BLAST

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi243277.VC2645.

Structurei

3D structure databases

ProteinModelPortaliQ9KNT5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the peptidase M20A family. ArgE subfamily.Curated

Phylogenomic databases

eggNOGiCOG0624.
KOiK01438.
OMAiAANRICG.
OrthoDBiEOG60651W.

Family and domain databases

Gene3Di3.30.70.360. 1 hit.
HAMAPiMF_01108. ArgE.
InterProiIPR010169. AcOrn-deacetyl.
IPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR01892. AcOrn-deacetyl. 1 hit.
PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KNT5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLPSFLEVY EGLISTSSIS STDARWDEGN EQVIAKLADW LSALGFSIQI
60 70 80 90 100
EQVAPNKQNL IAKLGSGEGG LLLAGHSDTV PFDEGRWNYN PHALTQVNNR
110 120 130 140 150
FYGLGTADMK GFFAFIYEAV KNVDWSKQTK PLYVLATCDE ETTMLGARHF
160 170 180 190 200
TENAPFKPDY CIIGEPTSLV PIRAHKGHVA NAIRVTGKSG HSSNPALGVN
210 220 230 240 250
AIEIMHEVLF ALMQLRDRLI KEYHHPGFEI PTPTLNLGHI HGGDSPNRIC
260 270 280 290 300
GCCELHYDVR PLPGISLDGL DNLMHDALRE VQQKWPGRIE LVPLHDPIPG
310 320 330 340 350
YECAHDHPFI HGISEICEQE AQTVNYCTEA PFLQQVCPTL VLGPGSIDQA
360 370
HQPDEFLAFE FIDPTVRVLS RAMQKYCF
Length:378
Mass (Da):41,964
Last modified:October 1, 2000 - v1
Checksum:iF0CC5EC1892ECE8D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF95786.1.
PIRiC82049.
RefSeqiNP_232273.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF95786; AAF95786; VC_2645.
GeneIDi2615662.
KEGGivch:VC2645.
PATRICi20084314. VBIVibCho83274_2523.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA. Translation: AAF95786.1.
PIRiC82049.
RefSeqiNP_232273.1. NC_002505.1.

3D structure databases

ProteinModelPortaliQ9KNT5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243277.VC2645.

Protein family/group databases

MEROPSiM20.974.

Protocols and materials databases

DNASUi2615662.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF95786; AAF95786; VC_2645.
GeneIDi2615662.
KEGGivch:VC2645.
PATRICi20084314. VBIVibCho83274_2523.

Phylogenomic databases

eggNOGiCOG0624.
KOiK01438.
OMAiAANRICG.
OrthoDBiEOG60651W.

Enzyme and pathway databases

UniPathwayiUPA00068; UER00110.
BioCyciVCHO:VC2645-MONOMER.

Family and domain databases

Gene3Di3.30.70.360. 1 hit.
HAMAPiMF_01108. ArgE.
InterProiIPR010169. AcOrn-deacetyl.
IPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamiPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
SUPFAMiSSF55031. SSF55031. 1 hit.
TIGRFAMsiTIGR01892. AcOrn-deacetyl. 1 hit.
PROSITEiPS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.

Entry informationi

Entry nameiARGE_VIBCH
AccessioniPrimary (citable) accession number: Q9KNT5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: October 1, 2000
Last modified: January 7, 2015
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. Peptidase families
    Classification of peptidase families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.