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Q9KNT5 (ARGE_VIBCH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 87. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Acetylornithine deacetylase

Short name=AO
Short name=Acetylornithinase
EC=3.5.1.16
Alternative name(s):
N-acetylornithinase
Short name=NAO
Gene names
Name:argE
Ordered Locus Names:VC_2645
OrganismVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) [Reference proteome] [HAMAP]
Taxonomic identifier243277 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length378 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

N(2)-acetyl-L-ornithine + H2O = acetate + L-ornithine. HAMAP-Rule MF_01108

Cofactor

Binds 2 zinc or cobalt ions per subunit By similarity. HAMAP-Rule MF_01108

Glutathione By similarity. HAMAP-Rule MF_01108

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-ornithine from N(2)-acetyl-L-ornithine (linear): step 1/1. HAMAP-Rule MF_01108

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_01108

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_01108.

Sequence similarities

Belongs to the peptidase M20A family. ArgE subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 378378Acetylornithine deacetylase HAMAP-Rule MF_01108
PRO_0000185251

Sites

Active site781 By similarity
Active site1401Proton acceptor By similarity
Metal binding761Cobalt or zinc 1 By similarity
Metal binding1081Cobalt or zinc 1 By similarity
Metal binding1081Cobalt or zinc 2 By similarity
Metal binding1411Cobalt or zinc 2 By similarity
Metal binding1651Cobalt or zinc 1 By similarity
Metal binding3511Cobalt or zinc 2 By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9KNT5 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: F0CC5EC1892ECE8D

FASTA37841,964
        10         20         30         40         50         60 
MPLPSFLEVY EGLISTSSIS STDARWDEGN EQVIAKLADW LSALGFSIQI EQVAPNKQNL 

        70         80         90        100        110        120 
IAKLGSGEGG LLLAGHSDTV PFDEGRWNYN PHALTQVNNR FYGLGTADMK GFFAFIYEAV 

       130        140        150        160        170        180 
KNVDWSKQTK PLYVLATCDE ETTMLGARHF TENAPFKPDY CIIGEPTSLV PIRAHKGHVA 

       190        200        210        220        230        240 
NAIRVTGKSG HSSNPALGVN AIEIMHEVLF ALMQLRDRLI KEYHHPGFEI PTPTLNLGHI 

       250        260        270        280        290        300 
HGGDSPNRIC GCCELHYDVR PLPGISLDGL DNLMHDALRE VQQKWPGRIE LVPLHDPIPG 

       310        320        330        340        350        360 
YECAHDHPFI HGISEICEQE AQTVNYCTEA PFLQQVCPTL VLGPGSIDQA HQPDEFLAFE 

       370 
FIDPTVRVLS RAMQKYCF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE003852 Genomic DNA. Translation: AAF95786.1.
PIRC82049.
RefSeqNP_232273.1. NC_002505.1.

3D structure databases

ProteinModelPortalQ9KNT5.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243277.VC2645.

Protein family/group databases

MEROPSM20.974.

Protocols and materials databases

DNASU2615662.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF95786; AAF95786; VC_2645.
GeneID2615662.
KEGGvch:VC2645.
PATRIC20084314. VBIVibCho83274_2523.

Phylogenomic databases

eggNOGCOG0624.
KOK01438.
OMAADGIHAN.
OrthoDBEOG60651W.

Enzyme and pathway databases

BioCycVCHO:VC2645-MONOMER.
UniPathwayUPA00068; UER00110.

Family and domain databases

Gene3D3.30.70.360. 1 hit.
HAMAPMF_01108. ArgE.
InterProIPR010169. AcOrn-deacetyl.
IPR001261. ArgE/DapE_CS.
IPR002933. Peptidase_M20.
IPR011650. Peptidase_M20_dimer.
[Graphical view]
PfamPF07687. M20_dimer. 1 hit.
PF01546. Peptidase_M20. 1 hit.
[Graphical view]
SUPFAMSSF55031. SSF55031. 1 hit.
TIGRFAMsTIGR01892. AcOrn-deacetyl. 1 hit.
PROSITEPS00758. ARGE_DAPE_CPG2_1. 1 hit.
PS00759. ARGE_DAPE_CPG2_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARGE_VIBCH
AccessionPrimary (citable) accession number: Q9KNT5
Entry history
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 87 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Peptidase families

Classification of peptidase families and list of entries

PATHWAY comments

Index of metabolic and biosynthesis pathways