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Protein

Guanylate kinase

Gene

gmk

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential for recycling GMP and indirectly, cGMP.By similarity

Catalytic activityi

ATP + GMP = ADP + GDP.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 18ATPBy similarity8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • guanylate kinase activity Source: TIGR

GO - Biological processi

  • nucleobase-containing small molecule interconversion Source: TIGR

Keywordsi

Molecular functionKinase, Transferase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Guanylate kinase (EC:2.7.4.8)
Alternative name(s):
GMP kinase
Gene namesi
Name:gmk
Ordered Locus Names:VC_2708
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000000584 Componenti: Chromosome 1

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001706361 – 207Guanylate kinaseAdd BLAST207

Proteomic databases

PRIDEiQ9KNM4

Interactioni

Protein-protein interaction databases

STRINGi243277.VC2708

Structurei

3D structure databases

ProteinModelPortaliQ9KNM4
SMRiQ9KNM4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 184Guanylate kinase-likeAdd BLAST181

Sequence similaritiesi

Belongs to the guanylate kinase family.Curated

Phylogenomic databases

eggNOGiENOG4108UHA Bacteria
COG0194 LUCA
KOiK00942
OMAiAGNYYGT

Family and domain databases

HAMAPiMF_00328 Guanylate_kinase, 1 hit
InterProiView protein in InterPro
IPR008145 GK/Ca_channel_bsu
IPR008144 Guanylate_kin-like_dom
IPR017665 Guanylate_kinase
IPR020590 Guanylate_kinase_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00625 Guanylate_kin, 1 hit
SMARTiView protein in SMART
SM00072 GuKc, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR03263 guanyl_kin, 1 hit
PROSITEiView protein in PROSITE
PS00856 GUANYLATE_KINASE_1, 1 hit
PS50052 GUANYLATE_KINASE_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q9KNM4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGKGTLYIVS APSGAGKSSL IAALLEQNPT YAMKVSVSHT TRGMRPGEQD
60 70 80 90 100
GVHYHFVEKE HFIELIGKGE FLEYAEVFGN YYGTSRVWIE NTLNKGIDVF
110 120 130 140 150
LDIDWQGARQ IRSQMPEAKS IFILPPSKEE LERRLNTRGQ DSDAVIAKRM
160 170 180 190 200
GEAKSEISHY SEYDYVIIND DFDVALMDFK AIIRAERLKQ DKQAAKYSAM

LSALLAE
Length:207
Mass (Da):23,333
Last modified:April 27, 2001 - v2
Checksum:i0A007962E1B583F3
GO

Sequence cautioni

The sequence AAF95848 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003852 Genomic DNA Translation: AAF95848.1 Different initiation.
PIRiH82043
RefSeqiNP_232335.2, NC_002505.1
WP_000515790.1, NC_002505.1

Genome annotation databases

EnsemblBacteriaiAAF95848; AAF95848; VC_2708
GeneIDi2615536
KEGGivch:VC2708
PATRICifig|243277.26.peg.2583

Similar proteinsi

Entry informationi

Entry nameiKGUA_VIBCH
AccessioniPrimary (citable) accession number: Q9KNM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 27, 2001
Last sequence update: April 27, 2001
Last modified: May 23, 2018
This is version 98 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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