Q9KNM2SPOT_VIBCHGuanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase3.1.7.2Penta-phosphate guanosine-3'-pyrophosphohydrolase(ppGpp)asespoTVC_2710Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)BacteriaPseudomonadotaGammaproteobacteriaVibrionalesVibrionaceaeVibrioDNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]Regulation of the stringent response is the essential function of the conserved bacterial G protein CgtA in Vibrio cholerae.SUBUNITDISRUPTION PHENOTYPEIn eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.guanosine 3',5'-bis(diphosphate) + H2O = diphosphate + GDP + H(+)Mn(2+)Purine metabolism; ppGpp biosynthesis; ppGpp from GDP: step 1/1.Interacts with CgtA/Obg (AC Q9KUS8) in a yeast 2-hybrid assay.Essential for growth, it cannot be disrupted. It can be disrupted in a relA deletion strain (relA phosphorylates GTP to ppGpp).Belongs to the RelA/SpoT family.HydrolaseManganeseReference proteomeMYLFDSLKDVAQEYLTEPQIEALRQSYVVARDAHEGQTRSSGEPYIIHPVAVARILAEMRLDLETLQAALLHDVIEDCDVTKEDLDAHFGSSVAELVDGVSKLDKLKFRDRKEAQAENFRKMVLAMVQDIRVILIKLADRTPNMRTLGALRPDKKRRIARETLEIYAPLAHRLGIHNIKTELEELGFEALYPNRYRVLKEVVKAARGNRKEMIQRIHSEIEGRLQEVGLPARVVGREKNLFSIYNKMKTKEQRFHTIMDIYAFRIVVDTADTCYRVLGQVHSLYKPRPARMKDYIAVPKANGYQSLHTSMVGPHGVPVEVQIRTEDMDQMADKGVAAHWSYKANSERGGTTAQIKAQRWMQSLLELQQSAGNSFEFIENVKSDLFPDEIYVFTPKGRIVELPMGATAVDFAYAVHTDIGNTCVGARVDRTPYPLSQSLKSGQTVEIISAPGARPNAAWLNYVVTSRARTKIRQVLKTMRREDSITLGRRLLNHALGEHSVNEIAPENISKVLSDLKIASMDDLLAAIGLGELMSIVIARRLLGNADELTEPSKSGGNKNKLPIRGAEGILLTFANCCHPIPDDHIIAHVSPGRGLVVHRETCPNVRGYQKEPDKYMAVEWTKDYDQEFITELKVDMHNRQGALAELTNVISKTGSNIHGLSTEERDGRLYTVTVLLTTKDRVHLAGIMRKIRTMPHALKVRRRKN
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