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Q9KNJ2 (GLNA_VIBCH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 81. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glutamine synthetase

EC=6.3.1.2
Alternative name(s):
Glutamate--ammonia ligase
Gene names
Name:glnA
Ordered Locus Names:VC_2746
OrganismVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) [Reference proteome] [HAMAP]
Taxonomic identifier243277 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length469 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

Enzyme regulation

The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive By similarity.

Subunit structure

Oligomer of 12 subunits arranged in the form of two hexagons.

Subcellular location

Cytoplasm.

Sequence similarities

Belongs to the glutamine synthetase family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 469469Glutamine synthetase
PRO_0000153276

Amino acid modifications

Modified residue3981O-AMP-tyrosine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9KNJ2 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 0B8E33BFB182EEA4

FASTA46951,751
        10         20         30         40         50         60 
MSVENVLSLI QENEVKFVDL RFTDTKGKEQ HISIPAHQID ADFFEDGKMF DGSSVAGWKG 

        70         80         90        100        110        120 
INESDMVMMP DPSSAVLDPF TEDATLNIRC DILEPATMQG YDRDPRSIAK RAEEYMRSTG 

       130        140        150        160        170        180 
IADTVLVGPE PEFFLFDDVK FATNMSGSFF KIDDVEAAWN TGTEYEDGNK GHRPGVKGGY 

       190        200        210        220        230        240 
FPVAPVDSSQ DIRSAMCLIM EEMGLVVEAH HHEVATAGQN EIATRFNTLT TKADEIQIYK 

       250        260        270        280        290        300 
YVVHNVAHAF GKTATFMPKP LVGDNGSGMH VHQSLAKDGV NLFAGDKYGG LSETALYYIG 

       310        320        330        340        350        360 
GIIKHARALN AITNPSTNSY KRLVPHYEAP VMLAYSARNR SASIRIPVVP SPKARRIEVR 

       370        380        390        400        410        420 
FPDPAANPYL AFAAMLMAGL DGIKNKIHPG EAMDKDLYDL PAEEAAEIPK VAESLQQALQ 

       430        440        450        460 
YLDADREFLT AGGVFSDDFI DSYIALKTKD VERVNVAVHP LEFELYYSV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE003852 Genomic DNA. Translation: AAF95885.1.
PIRA82038.
RefSeqNP_232372.1. NC_002505.1.

3D structure databases

ProteinModelPortalQ9KNJ2.
SMRQ9KNJ2. Positions 2-469.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243277.VC2746.

Proteomic databases

PRIDEQ9KNJ2.

Protocols and materials databases

DNASU2614909.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF95885; AAF95885; VC_2746.
GeneID2614909.
KEGGvch:VC2746.
PATRIC20084512. VBIVibCho83274_2622.

Phylogenomic databases

eggNOGCOG0174.
KOK01915.
OMADMLLMPI.
OrthoDBEOG6B360N.

Enzyme and pathway databases

BioCycVCHO:VC2746-MONOMER.

Family and domain databases

Gene3D3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR001637. Gln_synth_I_adenylation_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMSSF54368. SSF54368. 1 hit.
TIGRFAMsTIGR00653. GlnA. 1 hit.
PROSITEPS00180. GLNA_1. 1 hit.
PS00182. GLNA_ADENYLATION. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameGLNA_VIBCH
AccessionPrimary (citable) accession number: Q9KNJ2
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: October 1, 2000
Last modified: May 14, 2014
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families