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Q9KNJ2

- GLNA_VIBCH

UniProt

Q9KNJ2 - GLNA_VIBCH

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Protein
Glutamine synthetase
Gene
glnA, VC_2746
Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

Enzyme regulationi

The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive By similarity.

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. glutamate-ammonia ligase activity Source: TIGR

GO - Biological processi

  1. glutamine biosynthetic process Source: TIGR
  2. nitrogen fixation Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVCHO:VC2746-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamine synthetase (EC:6.3.1.2)
Alternative name(s):
Glutamate--ammonia ligase
Gene namesi
Name:glnA
Ordered Locus Names:VC_2746
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584: Chromosome 1

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 469469Glutamine synthetase
PRO_0000153276Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei398 – 3981O-AMP-tyrosine By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PRIDEiQ9KNJ2.

Interactioni

Subunit structurei

Oligomer of 12 subunits arranged in the form of two hexagons.

Protein-protein interaction databases

STRINGi243277.VC2746.

Structurei

3D structure databases

ProteinModelPortaliQ9KNJ2.
SMRiQ9KNJ2. Positions 2-469.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0174.
KOiK01915.
OMAiDMLLMPI.
OrthoDBiEOG6B360N.

Family and domain databases

Gene3Di3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProiIPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR001637. Gln_synth_I_adenylation_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view]
PfamiPF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view]
SUPFAMiSSF54368. SSF54368. 1 hit.
TIGRFAMsiTIGR00653. GlnA. 1 hit.
PROSITEiPS00180. GLNA_1. 1 hit.
PS00182. GLNA_ADENYLATION. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KNJ2-1 [UniParc]FASTAAdd to Basket

« Hide

MSVENVLSLI QENEVKFVDL RFTDTKGKEQ HISIPAHQID ADFFEDGKMF    50
DGSSVAGWKG INESDMVMMP DPSSAVLDPF TEDATLNIRC DILEPATMQG 100
YDRDPRSIAK RAEEYMRSTG IADTVLVGPE PEFFLFDDVK FATNMSGSFF 150
KIDDVEAAWN TGTEYEDGNK GHRPGVKGGY FPVAPVDSSQ DIRSAMCLIM 200
EEMGLVVEAH HHEVATAGQN EIATRFNTLT TKADEIQIYK YVVHNVAHAF 250
GKTATFMPKP LVGDNGSGMH VHQSLAKDGV NLFAGDKYGG LSETALYYIG 300
GIIKHARALN AITNPSTNSY KRLVPHYEAP VMLAYSARNR SASIRIPVVP 350
SPKARRIEVR FPDPAANPYL AFAAMLMAGL DGIKNKIHPG EAMDKDLYDL 400
PAEEAAEIPK VAESLQQALQ YLDADREFLT AGGVFSDDFI DSYIALKTKD 450
VERVNVAVHP LEFELYYSV 469
Length:469
Mass (Da):51,751
Last modified:October 1, 2000 - v1
Checksum:i0B8E33BFB182EEA4
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003852 Genomic DNA. Translation: AAF95885.1.
PIRiA82038.
RefSeqiNP_232372.1. NC_002505.1.

Genome annotation databases

EnsemblBacteriaiAAF95885; AAF95885; VC_2746.
GeneIDi2614909.
KEGGivch:VC2746.
PATRICi20084512. VBIVibCho83274_2622.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003852 Genomic DNA. Translation: AAF95885.1 .
PIRi A82038.
RefSeqi NP_232372.1. NC_002505.1.

3D structure databases

ProteinModelPortali Q9KNJ2.
SMRi Q9KNJ2. Positions 2-469.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243277.VC2746.

Proteomic databases

PRIDEi Q9KNJ2.

Protocols and materials databases

DNASUi 2614909.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF95885 ; AAF95885 ; VC_2746 .
GeneIDi 2614909.
KEGGi vch:VC2746.
PATRICi 20084512. VBIVibCho83274_2622.

Phylogenomic databases

eggNOGi COG0174.
KOi K01915.
OMAi DMLLMPI.
OrthoDBi EOG6B360N.

Enzyme and pathway databases

BioCyci VCHO:VC2746-MONOMER.

Family and domain databases

Gene3Di 3.10.20.70. 1 hit.
3.30.590.10. 1 hit.
InterProi IPR008147. Gln_synt_beta.
IPR014746. Gln_synth/guanido_kin_cat_dom.
IPR008146. Gln_synth_cat_dom.
IPR027303. Gln_synth_gly_rich_site.
IPR004809. Gln_synth_I.
IPR001637. Gln_synth_I_adenylation_site.
IPR027302. Gln_synth_N_conserv_site.
[Graphical view ]
Pfami PF00120. Gln-synt_C. 1 hit.
PF03951. Gln-synt_N. 1 hit.
[Graphical view ]
SUPFAMi SSF54368. SSF54368. 1 hit.
TIGRFAMsi TIGR00653. GlnA. 1 hit.
PROSITEi PS00180. GLNA_1. 1 hit.
PS00182. GLNA_ADENYLATION. 1 hit.
PS00181. GLNA_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.

Entry informationi

Entry nameiGLNA_VIBCH
AccessioniPrimary (citable) accession number: Q9KNJ2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 20, 2001
Last sequence update: October 1, 2000
Last modified: September 3, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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