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Q9KNJ2

- GLNA_VIBCH

UniProt

Q9KNJ2 - GLNA_VIBCH

Protein

Glutamine synthetase

Gene

glnA

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine.

    Enzyme regulationi

    The activity of this enzyme is controlled by adenylation under conditions of abundant glutamine. The fully adenylated enzyme complex is inactive By similarity.By similarity

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. glutamate-ammonia ligase activity Source: TIGR

    GO - Biological processi

    1. glutamine biosynthetic process Source: TIGR
    2. nitrogen fixation Source: InterPro

    Keywords - Molecular functioni

    Ligase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciVCHO:VC2746-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Glutamine synthetase (EC:6.3.1.2)
    Alternative name(s):
    Glutamate--ammonia ligase
    Gene namesi
    Name:glnA
    Ordered Locus Names:VC_2746
    OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
    Taxonomic identifieri243277 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000000584: Chromosome 1

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 469469Glutamine synthetasePRO_0000153276Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei398 – 3981O-AMP-tyrosineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PRIDEiQ9KNJ2.

    Interactioni

    Subunit structurei

    Oligomer of 12 subunits arranged in the form of two hexagons.

    Protein-protein interaction databases

    STRINGi243277.VC2746.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9KNJ2.
    SMRiQ9KNJ2. Positions 2-469.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glutamine synthetase family.Curated

    Phylogenomic databases

    eggNOGiCOG0174.
    KOiK01915.
    OMAiDMLLMPI.
    OrthoDBiEOG6B360N.

    Family and domain databases

    Gene3Di3.10.20.70. 1 hit.
    3.30.590.10. 1 hit.
    InterProiIPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    IPR004809. Gln_synth_I.
    IPR001637. Gln_synth_I_adenylation_site.
    IPR027302. Gln_synth_N_conserv_site.
    [Graphical view]
    PfamiPF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view]
    SUPFAMiSSF54368. SSF54368. 1 hit.
    TIGRFAMsiTIGR00653. GlnA. 1 hit.
    PROSITEiPS00180. GLNA_1. 1 hit.
    PS00182. GLNA_ADENYLATION. 1 hit.
    PS00181. GLNA_ATP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9KNJ2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSVENVLSLI QENEVKFVDL RFTDTKGKEQ HISIPAHQID ADFFEDGKMF    50
    DGSSVAGWKG INESDMVMMP DPSSAVLDPF TEDATLNIRC DILEPATMQG 100
    YDRDPRSIAK RAEEYMRSTG IADTVLVGPE PEFFLFDDVK FATNMSGSFF 150
    KIDDVEAAWN TGTEYEDGNK GHRPGVKGGY FPVAPVDSSQ DIRSAMCLIM 200
    EEMGLVVEAH HHEVATAGQN EIATRFNTLT TKADEIQIYK YVVHNVAHAF 250
    GKTATFMPKP LVGDNGSGMH VHQSLAKDGV NLFAGDKYGG LSETALYYIG 300
    GIIKHARALN AITNPSTNSY KRLVPHYEAP VMLAYSARNR SASIRIPVVP 350
    SPKARRIEVR FPDPAANPYL AFAAMLMAGL DGIKNKIHPG EAMDKDLYDL 400
    PAEEAAEIPK VAESLQQALQ YLDADREFLT AGGVFSDDFI DSYIALKTKD 450
    VERVNVAVHP LEFELYYSV 469
    Length:469
    Mass (Da):51,751
    Last modified:October 1, 2000 - v1
    Checksum:i0B8E33BFB182EEA4
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE003852 Genomic DNA. Translation: AAF95885.1.
    PIRiA82038.
    RefSeqiNP_232372.1. NC_002505.1.

    Genome annotation databases

    EnsemblBacteriaiAAF95885; AAF95885; VC_2746.
    GeneIDi2614909.
    KEGGivch:VC2746.
    PATRICi20084512. VBIVibCho83274_2622.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE003852 Genomic DNA. Translation: AAF95885.1 .
    PIRi A82038.
    RefSeqi NP_232372.1. NC_002505.1.

    3D structure databases

    ProteinModelPortali Q9KNJ2.
    SMRi Q9KNJ2. Positions 2-469.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243277.VC2746.

    Proteomic databases

    PRIDEi Q9KNJ2.

    Protocols and materials databases

    DNASUi 2614909.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF95885 ; AAF95885 ; VC_2746 .
    GeneIDi 2614909.
    KEGGi vch:VC2746.
    PATRICi 20084512. VBIVibCho83274_2622.

    Phylogenomic databases

    eggNOGi COG0174.
    KOi K01915.
    OMAi DMLLMPI.
    OrthoDBi EOG6B360N.

    Enzyme and pathway databases

    BioCyci VCHO:VC2746-MONOMER.

    Family and domain databases

    Gene3Di 3.10.20.70. 1 hit.
    3.30.590.10. 1 hit.
    InterProi IPR008147. Gln_synt_beta.
    IPR014746. Gln_synth/guanido_kin_cat_dom.
    IPR008146. Gln_synth_cat_dom.
    IPR027303. Gln_synth_gly_rich_site.
    IPR004809. Gln_synth_I.
    IPR001637. Gln_synth_I_adenylation_site.
    IPR027302. Gln_synth_N_conserv_site.
    [Graphical view ]
    Pfami PF00120. Gln-synt_C. 1 hit.
    PF03951. Gln-synt_N. 1 hit.
    [Graphical view ]
    SUPFAMi SSF54368. SSF54368. 1 hit.
    TIGRFAMsi TIGR00653. GlnA. 1 hit.
    PROSITEi PS00180. GLNA_1. 1 hit.
    PS00182. GLNA_ADENYLATION. 1 hit.
    PS00181. GLNA_ATP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39315 / El Tor Inaba N16961.

    Entry informationi

    Entry nameiGLNA_VIBCH
    AccessioniPrimary (citable) accession number: Q9KNJ2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 20, 2001
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3