Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9KN67

- PNCB_VIBCH

UniProt

Q9KN67 - PNCB_VIBCH

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. ligase activity Source: UniProtKB-KW
  2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
  3. nicotinate phosphoribosyltransferase activity Source: TIGR

GO - Biological processi

  1. NAD biosynthetic process Source: UniProtKB-UniPathway
  2. NADH metabolic process Source: TIGR
  3. nicotinate nucleotide biosynthetic process Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Ligase, Transferase

Keywords - Biological processi

Pyridine nucleotide biosynthesis

Enzyme and pathway databases

BioCyciVCHO:VCA0098-MONOMER.
UniPathwayiUPA00253; UER00457.

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:VC_A0098
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 435435Nicotinate phosphoribosyltransferasePRO_0000205847Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243277.VCA0098.

Structurei

Secondary structure

1
435
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni3 – 53Combined sources
Beta strandi16 – 183Combined sources
Helixi19 – 3113Combined sources
Beta strandi36 – 4510Combined sources
Turni47 – 493Combined sources
Helixi50 – 6213Combined sources
Helixi63 – 653Combined sources
Helixi70 – 7910Combined sources
Helixi85 – 917Combined sources
Helixi98 – 1014Combined sources
Beta strandi102 – 1076Combined sources
Beta strandi114 – 1229Combined sources
Helixi123 – 1264Combined sources
Helixi129 – 14517Combined sources
Helixi153 – 17220Combined sources
Beta strandi179 – 1813Combined sources
Helixi190 – 20314Combined sources
Helixi205 – 2073Combined sources
Beta strandi208 – 2136Combined sources
Helixi214 – 2207Combined sources
Helixi230 – 23910Combined sources
Helixi242 – 2443Combined sources
Helixi245 – 25612Combined sources
Beta strandi263 – 2664Combined sources
Helixi271 – 2777Combined sources
Helixi280 – 2856Combined sources
Beta strandi288 – 2914Combined sources
Helixi296 – 30914Combined sources
Helixi314 – 3163Combined sources
Beta strandi317 – 3215Combined sources
Helixi327 – 33711Combined sources
Turni338 – 3403Combined sources
Beta strandi341 – 3477Combined sources
Helixi349 – 3524Combined sources
Beta strandi370 – 3789Combined sources
Helixi390 – 3923Combined sources
Helixi398 – 40710Combined sources
Helixi414 – 42512Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HL7X-ray1.80A/B2-435[»]
ProteinModelPortaliQ9KN67.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1488.
KOiK00763.
OMAiQAVFHRY.
OrthoDBiEOG6X10XB.

Family and domain databases

HAMAPiMF_00570. NAPRTase.
InterProiIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PANTHERiPTHR11098. PTHR11098. 1 hit.
PfamiPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFiPIRSF000484. NAPRT. 1 hit.
SUPFAMiSSF51690. SSF51690. 1 hit.
TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9KN67-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNPRLFSPHI IRSLLDLDAY KINMMQAIHH FYPDVSVRYE LIVRSEEDAS
60 70 80 90 100
GLLDAIRQEI AHLGTLRFSD ADIHYLTQHA PHLKATFLQS LRYFHFVPQE
110 120 130 140 150
QVEMGIVKQG GKQQLRISIR GSWRDTILYE TLVMAIVSEV RSRQRWAEVP
160 170 180 190 200
ADLPLKVLKT KLDQLKAEIE RRGINNFSLT EMGTRRRFSS QVQRDVLACL
210 220 230 240 250
KQEIPQWVLG TSNYHFAREF DLKPIGTIAH EWFMGHQALV NERDSQQVAL
260 270 280 290 300
ERWLTAFDGM LAIAPTDTLT IDAFLNDFNR HLANAYDGVR HDSGCPFRWG
310 320 330 340 350
DKMIAHYQQL GIDPTTKLFI FSDGLDFDQA LELCEYFAGR VKISFGIGTF
360 370 380 390 400
LTNDLANWRN AAGVEYRPLS IVIKLAECQG RPVAKISDQP EKAMCEDPIF
410 420 430
LANLKRRFNI ELDVDALIQE LRHQKRSPRH YISAA
Length:435
Mass (Da):50,078
Last modified:October 1, 2000 - v1
Checksum:i2CEF5D950C6C11FE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003853 Genomic DNA. Translation: AAF96012.1.
PIRiH82501.
RefSeqiNP_232499.1. NC_002506.1.

Genome annotation databases

EnsemblBacteriaiAAF96012; AAF96012; VC_A0098.
GeneIDi2612706.
KEGGivch:VCA0098.
PATRICi20084775. VBIVibCho83274_2739.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003853 Genomic DNA. Translation: AAF96012.1 .
PIRi H82501.
RefSeqi NP_232499.1. NC_002506.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4HL7 X-ray 1.80 A/B 2-435 [» ]
ProteinModelPortali Q9KN67.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243277.VCA0098.

Protocols and materials databases

DNASUi 2612706.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF96012 ; AAF96012 ; VC_A0098 .
GeneIDi 2612706.
KEGGi vch:VCA0098.
PATRICi 20084775. VBIVibCho83274_2739.

Phylogenomic databases

eggNOGi COG1488.
KOi K00763.
OMAi QAVFHRY.
OrthoDBi EOG6X10XB.

Enzyme and pathway databases

UniPathwayi UPA00253 ; UER00457 .
BioCyci VCHO:VCA0098-MONOMER.

Family and domain databases

HAMAPi MF_00570. NAPRTase.
InterProi IPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view ]
PANTHERi PTHR11098. PTHR11098. 1 hit.
Pfami PF04095. NAPRTase. 1 hit.
[Graphical view ]
PIRSFi PIRSF000484. NAPRT. 1 hit.
SUPFAMi SSF51690. SSF51690. 1 hit.
TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.

Entry informationi

Entry nameiPNCB_VIBCH
AccessioniPrimary (citable) accession number: Q9KN67
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2002
Last sequence update: October 1, 2000
Last modified: November 26, 2014
This is version 85 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3