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Q9KN67

- PNCB_VIBCH

UniProt

Q9KN67 - PNCB_VIBCH

Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 84 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

    Catalytic activityi

    Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

    Pathwayi

    GO - Molecular functioni

    1. ligase activity Source: UniProtKB-KW
    2. nicotinate-nucleotide diphosphorylase (carboxylating) activity Source: InterPro
    3. nicotinate phosphoribosyltransferase activity Source: TIGR

    GO - Biological processi

    1. NAD biosynthetic process Source: UniProtKB-UniPathway
    2. NADH metabolic process Source: TIGR
    3. nicotinate nucleotide biosynthetic process Source: InterPro

    Keywords - Molecular functioni

    Ligase, Transferase

    Keywords - Biological processi

    Pyridine nucleotide biosynthesis

    Enzyme and pathway databases

    BioCyciVCHO:VCA0098-MONOMER.
    UniPathwayiUPA00253; UER00457.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
    Short name:
    NAPRTaseUniRule annotation
    Gene namesi
    Name:pncBUniRule annotation
    Ordered Locus Names:VC_A0098
    OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
    Taxonomic identifieri243277 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000000584: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 435435Nicotinate phosphoribosyltransferasePRO_0000205847Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243277.VCA0098.

    Structurei

    Secondary structure

    1
    435
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Turni3 – 53
    Beta strandi16 – 183
    Helixi19 – 3113
    Beta strandi36 – 4510
    Turni47 – 493
    Helixi50 – 6213
    Helixi63 – 653
    Helixi70 – 7910
    Helixi85 – 917
    Helixi98 – 1014
    Beta strandi102 – 1076
    Beta strandi114 – 1229
    Helixi123 – 1264
    Helixi129 – 14517
    Helixi153 – 17220
    Beta strandi179 – 1813
    Helixi190 – 20314
    Helixi205 – 2073
    Beta strandi208 – 2136
    Helixi214 – 2207
    Helixi230 – 23910
    Helixi242 – 2443
    Helixi245 – 25612
    Beta strandi263 – 2664
    Helixi271 – 2777
    Helixi280 – 2856
    Beta strandi288 – 2914
    Helixi296 – 30914
    Helixi314 – 3163
    Beta strandi317 – 3215
    Helixi327 – 33711
    Turni338 – 3403
    Beta strandi341 – 3477
    Helixi349 – 3524
    Beta strandi370 – 3789
    Helixi390 – 3923
    Helixi398 – 40710
    Helixi414 – 42512

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4HL7X-ray1.80A/B2-435[»]
    ProteinModelPortaliQ9KN67.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NAPRTase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1488.
    KOiK00763.
    OMAiQAVFHRY.
    OrthoDBiEOG6X10XB.

    Family and domain databases

    HAMAPiMF_00570. NAPRTase.
    InterProiIPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view]
    PANTHERiPTHR11098. PTHR11098. 1 hit.
    PfamiPF04095. NAPRTase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000484. NAPRT. 1 hit.
    SUPFAMiSSF51690. SSF51690. 1 hit.
    TIGRFAMsiTIGR01514. NAPRTase. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q9KN67-1 [UniParc]FASTAAdd to Basket

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    MNPRLFSPHI IRSLLDLDAY KINMMQAIHH FYPDVSVRYE LIVRSEEDAS    50
    GLLDAIRQEI AHLGTLRFSD ADIHYLTQHA PHLKATFLQS LRYFHFVPQE 100
    QVEMGIVKQG GKQQLRISIR GSWRDTILYE TLVMAIVSEV RSRQRWAEVP 150
    ADLPLKVLKT KLDQLKAEIE RRGINNFSLT EMGTRRRFSS QVQRDVLACL 200
    KQEIPQWVLG TSNYHFAREF DLKPIGTIAH EWFMGHQALV NERDSQQVAL 250
    ERWLTAFDGM LAIAPTDTLT IDAFLNDFNR HLANAYDGVR HDSGCPFRWG 300
    DKMIAHYQQL GIDPTTKLFI FSDGLDFDQA LELCEYFAGR VKISFGIGTF 350
    LTNDLANWRN AAGVEYRPLS IVIKLAECQG RPVAKISDQP EKAMCEDPIF 400
    LANLKRRFNI ELDVDALIQE LRHQKRSPRH YISAA 435
    Length:435
    Mass (Da):50,078
    Last modified:October 1, 2000 - v1
    Checksum:i2CEF5D950C6C11FE
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE003853 Genomic DNA. Translation: AAF96012.1.
    PIRiH82501.
    RefSeqiNP_232499.1. NC_002506.1.

    Genome annotation databases

    EnsemblBacteriaiAAF96012; AAF96012; VC_A0098.
    GeneIDi2612706.
    KEGGivch:VCA0098.
    PATRICi20084775. VBIVibCho83274_2739.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE003853 Genomic DNA. Translation: AAF96012.1 .
    PIRi H82501.
    RefSeqi NP_232499.1. NC_002506.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4HL7 X-ray 1.80 A/B 2-435 [» ]
    ProteinModelPortali Q9KN67.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243277.VCA0098.

    Protocols and materials databases

    DNASUi 2612706.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF96012 ; AAF96012 ; VC_A0098 .
    GeneIDi 2612706.
    KEGGi vch:VCA0098.
    PATRICi 20084775. VBIVibCho83274_2739.

    Phylogenomic databases

    eggNOGi COG1488.
    KOi K00763.
    OMAi QAVFHRY.
    OrthoDBi EOG6X10XB.

    Enzyme and pathway databases

    UniPathwayi UPA00253 ; UER00457 .
    BioCyci VCHO:VCA0098-MONOMER.

    Family and domain databases

    HAMAPi MF_00570. NAPRTase.
    InterProi IPR006406. Nic_PRibTrfase.
    IPR007229. Nic_PRibTrfase-Fam.
    IPR002638. Quinolinate_PRibosylTrfase_C.
    [Graphical view ]
    PANTHERi PTHR11098. PTHR11098. 1 hit.
    Pfami PF04095. NAPRTase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000484. NAPRT. 1 hit.
    SUPFAMi SSF51690. SSF51690. 1 hit.
    TIGRFAMsi TIGR01514. NAPRTase. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39315 / El Tor Inaba N16961.

    Entry informationi

    Entry nameiPNCB_VIBCH
    AccessioniPrimary (citable) accession number: Q9KN67
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2002
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 84 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3