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Protein

CAI-1 autoinducer synthase

Gene

cqsA

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Required for the synthesis of the quorum-sensing autoinducer CAI-1 ((S)-3-hydroxytridecan-4-one) which probably functions as an intragenus signal.1 Publication

Cofactori

GO - Molecular functioni

  • pyridoxal phosphate binding Source: InterPro
  • transaminase activity Source: TIGR
  • transferase activity, transferring acyl groups Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Molecular functionAcyltransferase, Aminotransferase, Transferase
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-19105
VCHO:VCA0523-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
CAI-1 autoinducer synthase (EC:2.3.-.-)
Alternative name(s):
Cholerae quorum-sensing autoinducer
Gene namesi
Name:cqsA
Ordered Locus Names:VC_A0523
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000000584 Componenti: Chromosome 2

Pathology & Biotechi

Chemistry databases

DrugBankiDB08364 1-{[(1E)-(3-HYDROXY-2-METHYL-5-{[(TRIHYDROXY-LAMBDA^5^-PHOSPHANYL)OXY]METHYL}PYRIDIN-4-YL)METHYLIDENE]AMINO}UNDECAN-2-ONE

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003168991 – 389CAI-1 autoinducer synthaseAdd BLAST389

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei236N6-(pyridoxal phosphate)lysineBy similarity1

Proteomic databases

PRIDEiQ9KM65

Interactioni

Protein-protein interaction databases

STRINGi243277.VCA0523

Structurei

Secondary structure

1389
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi8 – 21Combined sources14
Turni22 – 24Combined sources3
Beta strandi41 – 43Combined sources3
Helixi56 – 67Combined sources12
Helixi77 – 80Combined sources4
Turni83 – 85Combined sources3
Helixi88 – 97Combined sources10
Beta strandi100 – 106Combined sources7
Helixi108 – 119Combined sources12
Beta strandi125 – 129Combined sources5
Helixi134 – 142Combined sources9
Beta strandi146 – 150Combined sources5
Helixi155 – 165Combined sources11
Beta strandi169 – 175Combined sources7
Turni177 – 179Combined sources3
Helixi185 – 195Combined sources11
Beta strandi198 – 202Combined sources5
Turni204 – 209Combined sources6
Helixi212 – 214Combined sources3
Helixi217 – 220Combined sources4
Helixi224 – 226Combined sources3
Beta strandi228 – 236Combined sources9
Beta strandi243 – 250Combined sources8
Helixi251 – 253Combined sources3
Helixi255 – 258Combined sources4
Helixi260 – 264Combined sources5
Helixi270 – 285Combined sources16
Helixi287 – 305Combined sources19
Turni306 – 308Combined sources3
Beta strandi314 – 324Combined sources11
Helixi325 – 337Combined sources13
Beta strandi343 – 345Combined sources3
Turni347 – 349Combined sources3
Beta strandi355 – 360Combined sources6
Helixi367 – 383Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2WK7X-ray2.50A/B1-389[»]
2WK8X-ray2.10A/B1-389[»]
2WK9X-ray1.90A/B1-389[»]
2WKAX-ray1.91A/B1-389[»]
3HQTX-ray2.70A/B1-389[»]
3KKIX-ray1.80A/B1-389[»]
ProteinModelPortaliQ9KM65
SMRiQ9KM65
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9KM65

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG4107KBT Bacteria
COG0156 LUCA
KOiK10915
OMAiVMQSNDY

Family and domain databases

Gene3Di3.40.640.10, 1 hit
3.90.1150.10, 2 hits
InterProiView protein in InterPro
IPR004839 Aminotransferase_I/II
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PfamiView protein in Pfam
PF00155 Aminotran_1_2, 1 hit
SUPFAMiSSF53383 SSF53383, 1 hit

Sequencei

Sequence statusi: Complete.

Q9KM65-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNKPQLPDFI QNKIDHYIEN YFDINKNGKH LVLGKQASPD DIILQSNDYL
60 70 80 90 100
ALANHPLIKA RLAKSLLEEQ QSLFMSASFL QNDYDKPMIE KRLAKFTGFD
110 120 130 140 150
ECLLSQSGWN ANVGLLQTIC QPNTNVYIDF FAHMSLWEGA RYANAQAHPF
160 170 180 190 200
MHNNCDHLRM LIQRHGPGII VVDSIYSTLG TIAPLAELVN ISKEFGCALL
210 220 230 240 250
VDESHSLGTH GPNGAGLLAE LGLTREVHFM TASLAKTFAY RAGAIWCNNE
260 270 280 290 300
VNRCVPFISY PAIFSSTLLP YEAAGLETTL EIIESADNRR QHLDRMARKL
310 320 330 340 350
RIGLSQLGLT IRSESQIIGL ETGDERNTEK VRDYLESNGV FGSVFCRPAT
360 370 380
SKNKNIIRLS LNSDVNDEQI AKIIEVCSDA VNYGDFYFR
Length:389
Mass (Da):43,594
Last modified:October 1, 2000 - v1
Checksum:iAB37F11195D54C74
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003853 Genomic DNA Translation: AAF96426.1
PIRiH82448
RefSeqiNP_232914.1, NC_002506.1
WP_001039912.1, NC_002506.1

Genome annotation databases

EnsemblBacteriaiAAF96426; AAF96426; VC_A0523
GeneIDi2612753
KEGGivch:VCA0523
PATRICifig|243277.26.peg.3149

Similar proteinsi

Entry informationi

Entry nameiCQSA_VIBCH
AccessioniPrimary (citable) accession number: Q9KM65
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 1, 2000
Last modified: May 23, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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