SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9KLX7

- FTHS_VIBCH

UniProt

Q9KLX7 - FTHS_VIBCH

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Formate--tetrahydrofolate ligase

Gene
fhs, VC_A0614
Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: TIGR

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. histidine biosynthetic process Source: TIGR
  3. methionine biosynthetic process Source: TIGR
  4. one-carbon metabolic process Source: TIGR
  5. pantothenate biosynthetic process Source: TIGR
  6. purine nucleobase biosynthetic process Source: TIGR
  7. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligase (EC:6.3.4.3)
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name:
FHS
Short name:
FTHFS
Gene namesi
Name:fhs
Ordered Locus Names:VC_A0614
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 582582Formate--tetrahydrofolate ligaseUniRule annotationPRO_0000199407Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243277.VCA0614.

Structurei

3D structure databases

ProteinModelPortaliQ9KLX7.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2759.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KLX7-1 [UniParc]FASTAAdd to Basket

« Hide

MLPDIEICRA TPLAPIDTIA QKAGLHANEY ESHGQHKAKV SLHCLERLAN    50
KPKGKFILVT AITPTPLGEG KTVTTIGLAQ GLAKLNHSVM ACIRQPSMGP 100
IFGVKGGAAG GGYSQVAPME ELNLHLTGDI HAVTAAHNLA AAAIDARIYH 150
EQRLGYADFE RRTGMPALRI DPKQVIWKRV MDHNDRALRM VTVGRNEPGK 200
NINGYEREDG FDISAASELM AILALASDLR DLRRRIGNVV LAYDLDGNPV 250
TTEDLKVAGA MAVSMKEAIE PTLMQTLEGV PTLIHAGPFA NIAHGNSSII 300
ADEIATRLAD YTVTEGGFGS DMGFEKACNI KAKASGKTPD CAVIVATLRG 350
LKANSGLYDL RPGQAVPDAL FAPDSAALQA GFANLKWHID NVNQYGVPAV 400
VAINRFPQDC AEELEQLVKL IEALPNRVSV AISEGFAKGG EGTKLLAEKV 450
VEQCQHPTKF TPLYDSGIPL DEKLKAVAVK GYGAAEIALS DKAAQQLAKL 500
QTQGFDHLAV CLAKTPLSIS TDPAIKGAPR DFIVPIRELR LCAGAEFVYA 550
LCGSVMTMPG LPEKPSFMAL DIDQHGNIVG LS 582
Length:582
Mass (Da):62,074
Last modified:December 6, 2005 - v2
Checksum:i51C920CE75F6E1EC
GO

Sequence cautioni

The sequence AAF96515.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003853 Genomic DNA. Translation: AAF96515.1. Different initiation.
PIRiB82439.
RefSeqiNP_233003.2. NC_002506.1.

Genome annotation databases

EnsemblBacteriaiAAF96515; AAF96515; VC_A0614.
GeneIDi2612837.
KEGGivch:VCA0614.
PATRICi20085784. VBIVibCho83274_3242.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003853 Genomic DNA. Translation: AAF96515.1 . Different initiation.
PIRi B82439.
RefSeqi NP_233003.2. NC_002506.1.

3D structure databases

ProteinModelPortali Q9KLX7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243277.VCA0614.

Protocols and materials databases

DNASUi 2612837.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF96515 ; AAF96515 ; VC_A0614 .
GeneIDi 2612837.
KEGGi vch:VCA0614.
PATRICi 20085784. VBIVibCho83274_3242.

Phylogenomic databases

eggNOGi COG2759.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.

Entry informationi

Entry nameiFTHS_VIBCH
AccessioniPrimary (citable) accession number: Q9KLX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: May 14, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi