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Q9KLX7

- FTHS_VIBCH

UniProt

Q9KLX7 - FTHS_VIBCH

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 74 (01 Oct 2014)
      Sequence version 2 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

    Pathwayi

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi65 – 728ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. formate-tetrahydrofolate ligase activity Source: TIGR

    GO - Biological processi

    1. folic acid-containing compound biosynthetic process Source: InterPro
    2. histidine biosynthetic process Source: TIGR
    3. methionine biosynthetic process Source: TIGR
    4. one-carbon metabolic process Source: TIGR
    5. pantothenate biosynthetic process Source: TIGR
    6. purine nucleobase biosynthetic process Source: TIGR
    7. tetrahydrofolate interconversion Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Ligase

    Keywords - Biological processi

    One-carbon metabolism

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    UniPathwayiUPA00193.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
    Alternative name(s):
    Formyltetrahydrofolate synthetaseUniRule annotation
    Short name:
    FHSUniRule annotation
    Short name:
    FTHFSUniRule annotation
    Gene namesi
    Name:fhsUniRule annotation
    Ordered Locus Names:VC_A0614
    OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
    Taxonomic identifieri243277 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000000584: Chromosome 2

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 582582Formate--tetrahydrofolate ligasePRO_0000199407Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi243277.VCA0614.

    Structurei

    3D structure databases

    ProteinModelPortaliQ9KLX7.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG2759.
    KOiK01938.
    OMAiLKHHGGV.
    OrthoDBiEOG6PCPSP.

    Family and domain databases

    Gene3Di3.40.50.300. 2 hits.
    HAMAPiMF_01543. FTHFS.
    InterProiIPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view]
    PfamiPF01268. FTHFS. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiPS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9KLX7-1 [UniParc]FASTAAdd to Basket

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    MLPDIEICRA TPLAPIDTIA QKAGLHANEY ESHGQHKAKV SLHCLERLAN    50
    KPKGKFILVT AITPTPLGEG KTVTTIGLAQ GLAKLNHSVM ACIRQPSMGP 100
    IFGVKGGAAG GGYSQVAPME ELNLHLTGDI HAVTAAHNLA AAAIDARIYH 150
    EQRLGYADFE RRTGMPALRI DPKQVIWKRV MDHNDRALRM VTVGRNEPGK 200
    NINGYEREDG FDISAASELM AILALASDLR DLRRRIGNVV LAYDLDGNPV 250
    TTEDLKVAGA MAVSMKEAIE PTLMQTLEGV PTLIHAGPFA NIAHGNSSII 300
    ADEIATRLAD YTVTEGGFGS DMGFEKACNI KAKASGKTPD CAVIVATLRG 350
    LKANSGLYDL RPGQAVPDAL FAPDSAALQA GFANLKWHID NVNQYGVPAV 400
    VAINRFPQDC AEELEQLVKL IEALPNRVSV AISEGFAKGG EGTKLLAEKV 450
    VEQCQHPTKF TPLYDSGIPL DEKLKAVAVK GYGAAEIALS DKAAQQLAKL 500
    QTQGFDHLAV CLAKTPLSIS TDPAIKGAPR DFIVPIRELR LCAGAEFVYA 550
    LCGSVMTMPG LPEKPSFMAL DIDQHGNIVG LS 582
    Length:582
    Mass (Da):62,074
    Last modified:December 6, 2005 - v2
    Checksum:i51C920CE75F6E1EC
    GO

    Sequence cautioni

    The sequence AAF96515.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE003853 Genomic DNA. Translation: AAF96515.1. Different initiation.
    PIRiB82439.
    RefSeqiNP_233003.2. NC_002506.1.

    Genome annotation databases

    EnsemblBacteriaiAAF96515; AAF96515; VC_A0614.
    GeneIDi2612837.
    KEGGivch:VCA0614.
    PATRICi20085784. VBIVibCho83274_3242.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE003853 Genomic DNA. Translation: AAF96515.1 . Different initiation.
    PIRi B82439.
    RefSeqi NP_233003.2. NC_002506.1.

    3D structure databases

    ProteinModelPortali Q9KLX7.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243277.VCA0614.

    Protocols and materials databases

    DNASUi 2612837.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF96515 ; AAF96515 ; VC_A0614 .
    GeneIDi 2612837.
    KEGGi vch:VCA0614.
    PATRICi 20085784. VBIVibCho83274_3242.

    Phylogenomic databases

    eggNOGi COG2759.
    KOi K01938.
    OMAi LKHHGGV.
    OrthoDBi EOG6PCPSP.

    Enzyme and pathway databases

    UniPathwayi UPA00193 .

    Family and domain databases

    Gene3Di 3.40.50.300. 2 hits.
    HAMAPi MF_01543. FTHFS.
    InterProi IPR000559. Formate_THF_ligase.
    IPR020628. Formate_THF_ligase_CS.
    IPR027417. P-loop_NTPase.
    [Graphical view ]
    Pfami PF01268. FTHFS. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    PROSITEi PS00721. FTHFS_1. 1 hit.
    PS00722. FTHFS_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39315 / El Tor Inaba N16961.

    Entry informationi

    Entry nameiFTHS_VIBCH
    AccessioniPrimary (citable) accession number: Q9KLX7
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 74 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3