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Q9KLX7 (FTHS_VIBCH) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Formate--tetrahydrofolate ligase

EC=6.3.4.3
Alternative name(s):
Formyltetrahydrofolate synthetase
Short name=FHS
Short name=FTHFS
Gene names
Name:fhs
Ordered Locus Names:VC_A0614
OrganismVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) [Reference proteome] [HAMAP]
Taxonomic identifier243277 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length582 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP-Rule MF_01543

Pathway

One-carbon metabolism; tetrahydrofolate interconversion. HAMAP-Rule MF_01543

Sequence similarities

Belongs to the formate--tetrahydrofolate ligase family.

Sequence caution

The sequence AAF96515.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 582582Formate--tetrahydrofolate ligase HAMAP-Rule MF_01543
PRO_0000199407

Regions

Nucleotide binding65 – 728ATP By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9KLX7 [UniParc].

Last modified December 6, 2005. Version 2.
Checksum: 51C920CE75F6E1EC

FASTA58262,074
        10         20         30         40         50         60 
MLPDIEICRA TPLAPIDTIA QKAGLHANEY ESHGQHKAKV SLHCLERLAN KPKGKFILVT 

        70         80         90        100        110        120 
AITPTPLGEG KTVTTIGLAQ GLAKLNHSVM ACIRQPSMGP IFGVKGGAAG GGYSQVAPME 

       130        140        150        160        170        180 
ELNLHLTGDI HAVTAAHNLA AAAIDARIYH EQRLGYADFE RRTGMPALRI DPKQVIWKRV 

       190        200        210        220        230        240 
MDHNDRALRM VTVGRNEPGK NINGYEREDG FDISAASELM AILALASDLR DLRRRIGNVV 

       250        260        270        280        290        300 
LAYDLDGNPV TTEDLKVAGA MAVSMKEAIE PTLMQTLEGV PTLIHAGPFA NIAHGNSSII 

       310        320        330        340        350        360 
ADEIATRLAD YTVTEGGFGS DMGFEKACNI KAKASGKTPD CAVIVATLRG LKANSGLYDL 

       370        380        390        400        410        420 
RPGQAVPDAL FAPDSAALQA GFANLKWHID NVNQYGVPAV VAINRFPQDC AEELEQLVKL 

       430        440        450        460        470        480 
IEALPNRVSV AISEGFAKGG EGTKLLAEKV VEQCQHPTKF TPLYDSGIPL DEKLKAVAVK 

       490        500        510        520        530        540 
GYGAAEIALS DKAAQQLAKL QTQGFDHLAV CLAKTPLSIS TDPAIKGAPR DFIVPIRELR 

       550        560        570        580 
LCAGAEFVYA LCGSVMTMPG LPEKPSFMAL DIDQHGNIVG LS 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE003853 Genomic DNA. Translation: AAF96515.1. Different initiation.
PIRB82439.
RefSeqNP_233003.2. NC_002506.1.

3D structure databases

ProteinModelPortalQ9KLX7.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243277.VCA0614.

Protocols and materials databases

DNASU2612837.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF96515; AAF96515; VC_A0614.
GeneID2612837.
KEGGvch:VCA0614.
PATRIC20085784. VBIVibCho83274_3242.

Phylogenomic databases

eggNOGCOG2759.
KOK01938.
OMALKHHGGV.
OrthoDBEOG6PCPSP.

Enzyme and pathway databases

UniPathwayUPA00193.

Family and domain databases

Gene3D3.40.50.300. 2 hits.
HAMAPMF_01543. FTHFS.
InterProIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameFTHS_VIBCH
AccessionPrimary (citable) accession number: Q9KLX7
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: May 14, 2014
This is version 73 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways