Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q9KLX7

- FTHS_VIBCH

UniProt

Q9KLX7 - FTHS_VIBCH

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Formate--tetrahydrofolate ligase

Gene

fhs

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate.UniRule annotation

Pathwayi

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi65 – 728ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. formate-tetrahydrofolate ligase activity Source: TIGR

GO - Biological processi

  1. folic acid-containing compound biosynthetic process Source: InterPro
  2. histidine biosynthetic process Source: TIGR
  3. methionine biosynthetic process Source: TIGR
  4. one-carbon metabolic process Source: TIGR
  5. pantothenate biosynthetic process Source: TIGR
  6. purine nucleobase biosynthetic process Source: TIGR
  7. tetrahydrofolate interconversion Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00193.

Names & Taxonomyi

Protein namesi
Recommended name:
Formate--tetrahydrofolate ligaseUniRule annotation (EC:6.3.4.3UniRule annotation)
Alternative name(s):
Formyltetrahydrofolate synthetaseUniRule annotation
Short name:
FHSUniRule annotation
Short name:
FTHFSUniRule annotation
Gene namesi
Name:fhsUniRule annotation
Ordered Locus Names:VC_A0614
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 582582Formate--tetrahydrofolate ligasePRO_0000199407Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi243277.VCA0614.

Structurei

3D structure databases

ProteinModelPortaliQ9KLX7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the formate--tetrahydrofolate ligase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2759.
KOiK01938.
OMAiLKHHGGV.
OrthoDBiEOG6PCPSP.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
HAMAPiMF_01543. FTHFS.
InterProiIPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF01268. FTHFS. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KLX7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLPDIEICRA TPLAPIDTIA QKAGLHANEY ESHGQHKAKV SLHCLERLAN
60 70 80 90 100
KPKGKFILVT AITPTPLGEG KTVTTIGLAQ GLAKLNHSVM ACIRQPSMGP
110 120 130 140 150
IFGVKGGAAG GGYSQVAPME ELNLHLTGDI HAVTAAHNLA AAAIDARIYH
160 170 180 190 200
EQRLGYADFE RRTGMPALRI DPKQVIWKRV MDHNDRALRM VTVGRNEPGK
210 220 230 240 250
NINGYEREDG FDISAASELM AILALASDLR DLRRRIGNVV LAYDLDGNPV
260 270 280 290 300
TTEDLKVAGA MAVSMKEAIE PTLMQTLEGV PTLIHAGPFA NIAHGNSSII
310 320 330 340 350
ADEIATRLAD YTVTEGGFGS DMGFEKACNI KAKASGKTPD CAVIVATLRG
360 370 380 390 400
LKANSGLYDL RPGQAVPDAL FAPDSAALQA GFANLKWHID NVNQYGVPAV
410 420 430 440 450
VAINRFPQDC AEELEQLVKL IEALPNRVSV AISEGFAKGG EGTKLLAEKV
460 470 480 490 500
VEQCQHPTKF TPLYDSGIPL DEKLKAVAVK GYGAAEIALS DKAAQQLAKL
510 520 530 540 550
QTQGFDHLAV CLAKTPLSIS TDPAIKGAPR DFIVPIRELR LCAGAEFVYA
560 570 580
LCGSVMTMPG LPEKPSFMAL DIDQHGNIVG LS
Length:582
Mass (Da):62,074
Last modified:December 6, 2005 - v2
Checksum:i51C920CE75F6E1EC
GO

Sequence cautioni

The sequence AAF96515.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003853 Genomic DNA. Translation: AAF96515.1. Different initiation.
PIRiB82439.
RefSeqiNP_233003.2. NC_002506.1.

Genome annotation databases

EnsemblBacteriaiAAF96515; AAF96515; VC_A0614.
GeneIDi2612837.
KEGGivch:VCA0614.
PATRICi20085784. VBIVibCho83274_3242.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003853 Genomic DNA. Translation: AAF96515.1 . Different initiation.
PIRi B82439.
RefSeqi NP_233003.2. NC_002506.1.

3D structure databases

ProteinModelPortali Q9KLX7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243277.VCA0614.

Protocols and materials databases

DNASUi 2612837.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF96515 ; AAF96515 ; VC_A0614 .
GeneIDi 2612837.
KEGGi vch:VCA0614.
PATRICi 20085784. VBIVibCho83274_3242.

Phylogenomic databases

eggNOGi COG2759.
KOi K01938.
OMAi LKHHGGV.
OrthoDBi EOG6PCPSP.

Enzyme and pathway databases

UniPathwayi UPA00193 .

Family and domain databases

Gene3Di 3.40.50.300. 2 hits.
HAMAPi MF_01543. FTHFS.
InterProi IPR000559. Formate_THF_ligase.
IPR020628. Formate_THF_ligase_CS.
IPR027417. P-loop_NTPase.
[Graphical view ]
Pfami PF01268. FTHFS. 1 hit.
[Graphical view ]
SUPFAMi SSF52540. SSF52540. 1 hit.
PROSITEi PS00721. FTHFS_1. 1 hit.
PS00722. FTHFS_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.

Entry informationi

Entry nameiFTHS_VIBCH
AccessioniPrimary (citable) accession number: Q9KLX7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: October 1, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3