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Q9KLX5

- GCH1_VIBCH

UniProt

Q9KLX5 - GCH1_VIBCH

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Protein

GTP cyclohydrolase 1

Gene
folE, VC_A0616
Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi109 – 1091Zinc By similarity
Metal bindingi112 – 1121Zinc By similarity
Metal bindingi180 – 1801Zinc By similarity

GO - Molecular functioni

  1. GTP binding Source: UniProtKB-KW
  2. GTP cyclohydrolase I activity Source: TIGR
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. 7,8-dihydroneopterin 3'-triphosphate biosynthetic process Source: UniProtKB-UniPathway
  2. folic acid-containing compound metabolic process Source: TIGR
  3. one-carbon metabolic process Source: UniProtKB-HAMAP
  4. tetrahydrofolate biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

One-carbon metabolism

Keywords - Ligandi

GTP-binding, Metal-binding, Nucleotide-binding, Zinc

Enzyme and pathway databases

UniPathwayiUPA00848; UER00151.

Names & Taxonomyi

Protein namesi
Recommended name:
GTP cyclohydrolase 1 (EC:3.5.4.16)
Alternative name(s):
GTP cyclohydrolase I
Short name:
GTP-CH-I
Gene namesi
Name:folE
Ordered Locus Names:VC_A0616
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584: Chromosome 2

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: InterPro
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 217217GTP cyclohydrolase 1UniRule annotationPRO_0000119460Add
BLAST

Proteomic databases

PRIDEiQ9KLX5.

Interactioni

Subunit structurei

Toroid-shaped homodecamer, composed of two pentamers of five dimers By similarity.

Protein-protein interaction databases

STRINGi243277.VCA0616.

Structurei

3D structure databases

ProteinModelPortaliQ9KLX5.
SMRiQ9KLX5. Positions 4-217.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0302.
KOiK01495.
OMAiQRIAEHM.
OrthoDBiEOG6XHC8G.

Family and domain databases

HAMAPiMF_00223. FolE.
InterProiIPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view]
PANTHERiPTHR11109. PTHR11109. 1 hit.
PfamiPF01227. GTP_cyclohydroI. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00063. folE. 1 hit.
PROSITEiPS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KLX5-1 [UniParc]FASTAAdd to Basket

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MSGLSESAKL VKDALERRGL ETPMQPNLAT PAEKKEKIEQ HMREILNLLG    50
LDLTDDSLEE TPQRIAKMYV DEIFSGLDYA NFPKITVIEN KMKVSEMVKV 100
KDITLTSTCE HHLVTIDGTA AVAYIPRGKI IGLSKINRIV RFFAQRPQVQ 150
ERMTQQILVA LQTLLESDDV AVTIDATHYC VKSRGVMDAT SVTTTTALGG 200
IFKSNPATRA EFLHGLR 217
Length:217
Mass (Da):24,143
Last modified:October 10, 2002 - v2
Checksum:iD5D3E776BD633213
GO

Sequence cautioni

The sequence AAF96517.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003853 Genomic DNA. Translation: AAF96517.1. Different initiation.
PIRiD82439.
RefSeqiNP_233005.1. NC_002506.1.

Genome annotation databases

EnsemblBacteriaiAAF96517; AAF96517; VC_A0616.
GeneIDi2612591.
KEGGivch:VCA0616.
PATRICi20085788. VBIVibCho83274_3244.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003853 Genomic DNA. Translation: AAF96517.1 . Different initiation.
PIRi D82439.
RefSeqi NP_233005.1. NC_002506.1.

3D structure databases

ProteinModelPortali Q9KLX5.
SMRi Q9KLX5. Positions 4-217.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 243277.VCA0616.

Proteomic databases

PRIDEi Q9KLX5.

Protocols and materials databases

DNASUi 2612591.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF96517 ; AAF96517 ; VC_A0616 .
GeneIDi 2612591.
KEGGi vch:VCA0616.
PATRICi 20085788. VBIVibCho83274_3244.

Phylogenomic databases

eggNOGi COG0302.
KOi K01495.
OMAi QRIAEHM.
OrthoDBi EOG6XHC8G.

Enzyme and pathway databases

UniPathwayi UPA00848 ; UER00151 .

Family and domain databases

HAMAPi MF_00223. FolE.
InterProi IPR001474. GTP_CycHdrlase_I.
IPR018234. GTP_CycHdrlase_I_CS.
IPR020602. GTP_CycHdrlase_I_dom.
[Graphical view ]
PANTHERi PTHR11109. PTHR11109. 1 hit.
Pfami PF01227. GTP_cyclohydroI. 1 hit.
[Graphical view ]
TIGRFAMsi TIGR00063. folE. 1 hit.
PROSITEi PS00859. GTP_CYCLOHYDROL_1_1. 1 hit.
PS00860. GTP_CYCLOHYDROL_1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.

Entry informationi

Entry nameiGCH1_VIBCH
AccessioniPrimary (citable) accession number: Q9KLX5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: May 14, 2014
This is version 81 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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