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Q9KLD1 (SPEA_VIBCH) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Biosynthetic arginine decarboxylase

Short name=ADC
EC=4.1.1.19
Gene names
Name:speA
Ordered Locus Names:VC_A0815
OrganismVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961) [Reference proteome] [HAMAP]
Taxonomic identifier243277 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio

Protein attributes

Sequence length640 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the biosynthesis of agmatine from arginine By similarity. HAMAP-Rule MF_01417

Catalytic activity

L-arginine = agmatine + CO2. HAMAP-Rule MF_01417

Cofactor

Magnesium By similarity. HAMAP-Rule MF_01417

Pyridoxal phosphate By similarity. HAMAP-Rule MF_01417

Sequence similarities

Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.

Sequence caution

The sequence AAF96713.1 differs from that shown. Reason: Erroneous initiation.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 640640Biosynthetic arginine decarboxylase HAMAP-Rule MF_01417
PRO_0000149983

Regions

Region290 – 30011Substrate-binding Potential

Amino acid modifications

Modified residue1051N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q9KLD1 [UniParc].

Last modified March 29, 2004. Version 2.
Checksum: 851D1CE7D6E466F9

FASTA64072,249
        10         20         30         40         50         60 
MRYDVEQPSK LDRVRADYNV HYWSQGFFGI DDQGEVYVSP RKDKAHQTQL SSIVKQLEAR 

        70         80         90        100        110        120 
DLNLPVLVRF PQILHQRVHN ICDAFNQAIE EYDYPNKYLL VYPIKVNQQK EVVDEILASQ 

       130        140        150        160        170        180 
AELEHKQLGL EAGSKPELLA VLAMAQQASS VIVCNGYKDR EYIRLALIGE KLGHKVFIVL 

       190        200        210        220        230        240 
EKLSELDLVL KEAKSLGVKP RLGLRIRLAS QGAGKWQSSG GEKSKFGLAA SQVLTVINRL 

       250        260        270        280        290        300 
KAENQLEALQ LVHFHLGSQM ANIRDVRNGV NEAVRFYCEL RELGAHIDFF DVGGGLAVDY 

       310        320        330        340        350        360 
DGTRSQSSNS MNYGLHEYAR NIVSTVSDVC NLYGQPRPVI ISESGRSITA HHAVLITNVI 

       370        380        390        400        410        420 
GTEAYSPEEI PAPGADAPML LKNMWRGFEE VQHGTDDRAL IEIYNDTQSD LSEAHSQFAT 

       430        440        450        460        470        480 
GVLNLEHRAW AEQLSLRIYH ELRQKMSNKN RFHRPILDEL QERLADKFFV NFSLFQSLPD 

       490        500        510        520        530        540 
AWGIDQVFPV LPLSGLEEMN DRRAVMLDIT CDSDGAVEQY VEGQGIESTL PVPAWTSDKP 

       550        560        570        580        590        600 
YLMGFFLVGA YQEILGDMHN LFGDTHSAVV NINDNGESEI AFINEGDTVE DMMRYVHIDV 

       610        620        630        640 
DKIRTNYRQL VSQRVAKEEQ ETVLAELELG LSGYTYLEDF 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE003853 Genomic DNA. Translation: AAF96713.1. Different initiation.
PIRE82414.
RefSeqNP_233201.1. NC_002506.1.

3D structure databases

ProteinModelPortalQ9KLD1.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING243277.VCA0815.

Protocols and materials databases

DNASU2611850.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAF96713; AAF96713; VC_A0815.
GeneID2611850.
KEGGvch:VCA0815.
PATRIC20086176. VBIVibCho83274_3435.

Phylogenomic databases

eggNOGCOG1166.
KOK01585.
OMAMIHFHIG.
OrthoDBEOG676Z0R.
ProtClustDBPRK05354.

Family and domain databases

Gene3D2.40.37.10. 2 hits.
HAMAPMF_01417. SpeA.
InterProIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
[Graphical view]
PfamPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
TIGRFAMsTIGR01273. speA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameSPEA_VIBCH
AccessionPrimary (citable) accession number: Q9KLD1
Entry history
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 29, 2004
Last modified: February 19, 2014
This is version 69 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families