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Q9KLD1

- SPEA_VIBCH

UniProt

Q9KLD1 - SPEA_VIBCH

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Protein
Biosynthetic arginine decarboxylase
Gene
speA, VC_A0815
Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the biosynthesis of agmatine from arginine By similarity.UniRule annotation

Catalytic activityi

L-arginine = agmatine + CO2.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation
Pyridoxal phosphate By similarity.UniRule annotation

GO - Molecular functioni

  1. arginine decarboxylase activity Source: TIGR
  2. metal ion binding Source: UniProtKB-KW
Complete GO annotation...

GO - Biological processi

  1. arginine catabolic process Source: InterPro
  2. polyamine biosynthetic process Source: TIGR
  3. spermidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Decarboxylase, Lyase

Keywords - Biological processi

Polyamine biosynthesis, Spermidine biosynthesis

Keywords - Ligandi

Magnesium, Metal-binding, Pyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Biosynthetic arginine decarboxylase (EC:4.1.1.19)
Short name:
ADC
Gene namesi
Name:speA
Ordered Locus Names:VC_A0815
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584: Chromosome 2

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 640640Biosynthetic arginine decarboxylaseUniRule annotation
PRO_0000149983Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei105 – 1051N6-(pyridoxal phosphate)lysine By similarity

Interactioni

Protein-protein interaction databases

STRINGi243277.VCA0815.

Structurei

3D structure databases

ProteinModelPortaliQ9KLD1.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni290 – 30011Substrate-binding Reviewed prediction
Add
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1166.
KOiK01585.
OMAiIDHYVDG.
OrthoDBiEOG676Z0R.

Family and domain databases

Gene3Di2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPiMF_01417. SpeA.
InterProiIPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view]
PfamiPF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view]
PIRSFiPIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSiPR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMiSSF51419. SSF51419. 1 hit.
TIGRFAMsiTIGR01273. speA. 1 hit.

Sequencei

Sequence statusi: Complete.

Q9KLD1-1 [UniParc]FASTAAdd to Basket

« Hide

MRYDVEQPSK LDRVRADYNV HYWSQGFFGI DDQGEVYVSP RKDKAHQTQL    50
SSIVKQLEAR DLNLPVLVRF PQILHQRVHN ICDAFNQAIE EYDYPNKYLL 100
VYPIKVNQQK EVVDEILASQ AELEHKQLGL EAGSKPELLA VLAMAQQASS 150
VIVCNGYKDR EYIRLALIGE KLGHKVFIVL EKLSELDLVL KEAKSLGVKP 200
RLGLRIRLAS QGAGKWQSSG GEKSKFGLAA SQVLTVINRL KAENQLEALQ 250
LVHFHLGSQM ANIRDVRNGV NEAVRFYCEL RELGAHIDFF DVGGGLAVDY 300
DGTRSQSSNS MNYGLHEYAR NIVSTVSDVC NLYGQPRPVI ISESGRSITA 350
HHAVLITNVI GTEAYSPEEI PAPGADAPML LKNMWRGFEE VQHGTDDRAL 400
IEIYNDTQSD LSEAHSQFAT GVLNLEHRAW AEQLSLRIYH ELRQKMSNKN 450
RFHRPILDEL QERLADKFFV NFSLFQSLPD AWGIDQVFPV LPLSGLEEMN 500
DRRAVMLDIT CDSDGAVEQY VEGQGIESTL PVPAWTSDKP YLMGFFLVGA 550
YQEILGDMHN LFGDTHSAVV NINDNGESEI AFINEGDTVE DMMRYVHIDV 600
DKIRTNYRQL VSQRVAKEEQ ETVLAELELG LSGYTYLEDF 640
Length:640
Mass (Da):72,249
Last modified:March 29, 2004 - v2
Checksum:i851D1CE7D6E466F9
GO

Sequence cautioni

The sequence AAF96713.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003853 Genomic DNA. Translation: AAF96713.1. Different initiation.
PIRiE82414.
RefSeqiNP_233201.1. NC_002506.1.

Genome annotation databases

EnsemblBacteriaiAAF96713; AAF96713; VC_A0815.
GeneIDi2611850.
KEGGivch:VCA0815.
PATRICi20086176. VBIVibCho83274_3435.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE003853 Genomic DNA. Translation: AAF96713.1 . Different initiation.
PIRi E82414.
RefSeqi NP_233201.1. NC_002506.1.

3D structure databases

ProteinModelPortali Q9KLD1.
ModBasei Search...

Protein-protein interaction databases

STRINGi 243277.VCA0815.

Protocols and materials databases

DNASUi 2611850.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAF96713 ; AAF96713 ; VC_A0815 .
GeneIDi 2611850.
KEGGi vch:VCA0815.
PATRICi 20086176. VBIVibCho83274_3435.

Phylogenomic databases

eggNOGi COG1166.
KOi K01585.
OMAi IDHYVDG.
OrthoDBi EOG676Z0R.

Family and domain databases

Gene3Di 2.40.37.10. 2 hits.
3.20.20.10. 1 hit.
HAMAPi MF_01417. SpeA.
InterProi IPR009006. Ala_racemase/Decarboxylase_C.
IPR002985. Arg_decrbxlase.
IPR022643. De-COase2_C.
IPR022644. De-COase2_N.
IPR000183. Orn/DAP/Arg_de-COase.
IPR029066. PLP-binding_barrel.
[Graphical view ]
Pfami PF02784. Orn_Arg_deC_N. 1 hit.
PF00278. Orn_DAP_Arg_deC. 1 hit.
[Graphical view ]
PIRSFi PIRSF001336. Arg_decrbxlase. 1 hit.
PRINTSi PR01180. ARGDCRBXLASE.
PR01179. ODADCRBXLASE.
SUPFAMi SSF51419. SSF51419. 1 hit.
TIGRFAMsi TIGR01273. speA. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961.

Entry informationi

Entry nameiSPEA_VIBCH
AccessioniPrimary (citable) accession number: Q9KLD1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 29, 2004
Last sequence update: March 29, 2004
Last modified: June 11, 2014
This is version 71 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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