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Protein

Maltose/maltodextrin import ATP-binding protein MalK

Gene

malK

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of the ABC transporter complex MalEFGK involved in maltose/maltodextrin import. Responsible for energy coupling to the transport system.UniRule annotation

Catalytic activityi

ATP + H2O + maltose(Out) = ADP + phosphate + maltose(In).UniRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi36 – 43ATPUniRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-HAMAP
  • maltooligosaccharide-importing ATPase activity Source: UniProtKB-HAMAP
  • maltose-transporting ATPase activity Source: TIGR

GO - Biological processi

  • maltose transport Source: TIGR
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Sugar transport, Transport

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciVCHO:VCA0946-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Maltose/maltodextrin import ATP-binding protein MalKUniRule annotation (EC:3.6.3.19UniRule annotation)
Gene namesi
Name:malKUniRule annotation
Ordered Locus Names:VC_A0946
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
Proteomesi
  • UP000000584 Componenti: Chromosome 2

Subcellular locationi

  • Cell inner membrane UniRule annotation; Peripheral membrane protein UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000924841 – 373Maltose/maltodextrin import ATP-binding protein MalKAdd BLAST373

Interactioni

Subunit structurei

The complex is composed of two ATP-binding proteins (MalK), two transmembrane proteins (MalG and MalK) and a solute-binding protein (MalE).UniRule annotation

Protein-protein interaction databases

STRINGi243277.VCA0946.

Structurei

3D structure databases

ProteinModelPortaliQ9KL04.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 234ABC transporterUniRule annotationAdd BLAST231

Sequence similaritiesi

Belongs to the ABC transporter superfamily. Maltooligosaccharide importer (TC 3.A.1.1.1) family. [View classification]UniRule annotation
Contains 1 ABC transporter domain.UniRule annotation

Phylogenomic databases

eggNOGiENOG4108IJ9. Bacteria.
COG3839. LUCA.
KOiK10111.
OMAiADKIHRF.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR015855. ABC_transpr_MalK.
IPR008995. Mo/tungstate-bd_C_term_dom.
IPR027417. P-loop_NTPase.
IPR013611. Transp-assoc_OB_typ2.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
PF08402. TOBE_2. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF50331. SSF50331. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51245. MALK. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KL04-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASVTLKNVC KAYGDVLISK NVDLEIQEGE FVVFVGPSGC GKSTLLRCIA
60 70 80 90 100
GLEDITSGDL YIGEQRMNDV EPSKRGVGMV FQSYALYPHL NLYDNMSFGL
110 120 130 140 150
KLSKADKSEI KKRVDHAAEI LQLSHLLDRQ PKALSGGQRQ RVAIGRTLVS
160 170 180 190 200
QPNVFLLDEP LSNLDAALRV QMRSEITKLQ RKLGCTMIYV THDQVEAMTM
210 220 230 240 250
ADKIVVLDAG FVSQVGKPLE LYHYPQNRFV AGFIGSPKMN FMSVFIEGVE
260 270 280 290 300
KDRVQVQLSN GTTFWIPVDG TTVTRGERMS LGIRPEHLVE AEHGDAKIEG
310 320 330 340 350
KVMIVEKLGN ETQVYMNLKG SDSDVIYRQP DTLDVETGDT LTIGIPAHRC
360 370
HLFHSDGRAC RRLHKEKGVD LPA
Length:373
Mass (Da):41,405
Last modified:October 1, 2000 - v1
Checksum:iA15E521894CABA55
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti365K → Q in strain: Classical 569B / ATCC 25870 / Serotype O1. 1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF259974 Genomic DNA. Translation: AAF70304.1.
AE003853 Genomic DNA. Translation: AAF96842.1.
PIRiA82398.
RefSeqiNP_233330.1. NC_002506.1.
WP_000179238.1. NC_002506.1.

Genome annotation databases

EnsemblBacteriaiAAF96842; AAF96842; VC_A0946.
GeneIDi2612547.
KEGGivch:VCA0946.
PATRICi20086422. VBIVibCho83274_3558.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF259974 Genomic DNA. Translation: AAF70304.1.
AE003853 Genomic DNA. Translation: AAF96842.1.
PIRiA82398.
RefSeqiNP_233330.1. NC_002506.1.
WP_000179238.1. NC_002506.1.

3D structure databases

ProteinModelPortaliQ9KL04.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243277.VCA0946.

Protocols and materials databases

DNASUi2612547.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF96842; AAF96842; VC_A0946.
GeneIDi2612547.
KEGGivch:VCA0946.
PATRICi20086422. VBIVibCho83274_3558.

Phylogenomic databases

eggNOGiENOG4108IJ9. Bacteria.
COG3839. LUCA.
KOiK10111.
OMAiADKIHRF.

Enzyme and pathway databases

BioCyciVCHO:VCA0946-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR003593. AAA+_ATPase.
IPR003439. ABC_transporter-like.
IPR017871. ABC_transporter_CS.
IPR015855. ABC_transpr_MalK.
IPR008995. Mo/tungstate-bd_C_term_dom.
IPR027417. P-loop_NTPase.
IPR013611. Transp-assoc_OB_typ2.
[Graphical view]
PfamiPF00005. ABC_tran. 1 hit.
PF08402. TOBE_2. 1 hit.
[Graphical view]
SMARTiSM00382. AAA. 1 hit.
[Graphical view]
SUPFAMiSSF50331. SSF50331. 1 hit.
SSF52540. SSF52540. 1 hit.
PROSITEiPS00211. ABC_TRANSPORTER_1. 1 hit.
PS50893. ABC_TRANSPORTER_2. 1 hit.
PS51245. MALK. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMALK_VIBCH
AccessioniPrimary (citable) accession number: Q9KL04
Secondary accession number(s): Q9L531
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2004
Last sequence update: October 1, 2000
Last modified: October 5, 2016
This is version 96 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.