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Q9KL03

- Q9KL03_VIBCH

UniProt

Q9KL03 - Q9KL03_VIBCH

Protein
Submitted name:

Spermidine n1-acetyltransferase

Gene

VC_A0947

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (01 Oct 2000)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei30 – 301Sulfate 1
    Binding sitei30 – 301Sulfate 2
    Metal bindingi33 – 331CalciumImported
    Metal bindingi33 – 331MagnesiumImported
    Metal bindingi75 – 751CalciumImported
    Metal bindingi75 – 751MagnesiumImported
    Binding sitei78 – 781Sulfate 2; via amide nitrogen

    GO - Molecular functioni

    1. diamine N-acetyltransferase activity Source: TIGR
    2. metal ion binding Source: UniProtKB-KW

    GO - Biological processi

    1. polyamine catabolic process Source: TIGR

    Keywords - Molecular functioni

    TransferaseImported

    Keywords - Ligandi

    CalciumImported, MagnesiumImported, Metal-bindingImported

    Enzyme and pathway databases

    BioCyciVCHO:VCA0947-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Spermidine n1-acetyltransferaseImported
    Gene namesi
    Ordered Locus Names:VC_A0947Imported
    OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)Imported
    Taxonomic identifieri243277 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
    ProteomesiUP000000584: Chromosome 2

    Interactioni

    Protein-protein interaction databases

    STRINGi243277.VCA0947.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3EG7X-ray2.38A/B/C/D/E/F1-173[»]
    4JJXX-ray2.83A/B/C1-173[»]
    4JLYX-ray2.88A/B/C/D/E/F1-173[»]
    4MHDX-ray2.32A/B/C1-173[»]
    4MI4X-ray1.85A/B/C1-173[»]
    4MJ8X-ray2.04A/B/C1-173[»]
    4NCZX-ray1.89A/B/C1-173[»]
    ProteinModelPortaliQ9KL03.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ9KL03.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni95 – 1006Sulfate 1 binding

    Phylogenomic databases

    KOiK00657.
    OMAiIISPEHQ.
    OrthoDBiEOG6D5G79.

    Family and domain databases

    Gene3Di3.40.630.30. 1 hit.
    InterProiIPR016181. Acyl_CoA_acyltransferase.
    IPR000182. GNAT_dom.
    [Graphical view]
    PfamiPF13302. Acetyltransf_3. 1 hit.
    [Graphical view]
    SUPFAMiSSF55729. SSF55729. 1 hit.
    PROSITEiPS51186. GNAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q9KL03-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNSQLTLRAL ERGDLRFIHN LNNNRNIMSY WFEEPYESFD ELEELYNKHI    50
    HDNAERRFVV EDAQKNLIGL VELIEINYIH RSAEFQIIIA PEHQGKGFAR 100
    TLINRALDYS FTILNLHKIY LHVAVENPKA VHLYEECGFV EEGHLVEEFF 150
    INGRYQDVKR MYILQSKYLN RSE 173
    Length:173
    Mass (Da):20,675
    Last modified:October 1, 2000 - v1
    Checksum:i9821218EFF8E8AD8
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE003853 Genomic DNA. Translation: AAF96843.1.
    PIRiB82398.
    RefSeqiNP_233331.1. NC_002506.1.

    Genome annotation databases

    EnsemblBacteriaiAAF96843; AAF96843; VC_A0947.
    GeneIDi2612395.
    KEGGivch:VCA0947.
    PATRICi20086424. VBIVibCho83274_3559.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE003853 Genomic DNA. Translation: AAF96843.1 .
    PIRi B82398.
    RefSeqi NP_233331.1. NC_002506.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3EG7 X-ray 2.38 A/B/C/D/E/F 1-173 [» ]
    4JJX X-ray 2.83 A/B/C 1-173 [» ]
    4JLY X-ray 2.88 A/B/C/D/E/F 1-173 [» ]
    4MHD X-ray 2.32 A/B/C 1-173 [» ]
    4MI4 X-ray 1.85 A/B/C 1-173 [» ]
    4MJ8 X-ray 2.04 A/B/C 1-173 [» ]
    4NCZ X-ray 1.89 A/B/C 1-173 [» ]
    ProteinModelPortali Q9KL03.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 243277.VCA0947.

    Protocols and materials databases

    DNASUi 2612395.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAF96843 ; AAF96843 ; VC_A0947 .
    GeneIDi 2612395.
    KEGGi vch:VCA0947.
    PATRICi 20086424. VBIVibCho83274_3559.

    Phylogenomic databases

    KOi K00657.
    OMAi IISPEHQ.
    OrthoDBi EOG6D5G79.

    Enzyme and pathway databases

    BioCyci VCHO:VCA0947-MONOMER.

    Miscellaneous databases

    EvolutionaryTracei Q9KL03.

    Family and domain databases

    Gene3Di 3.40.630.30. 1 hit.
    InterProi IPR016181. Acyl_CoA_acyltransferase.
    IPR000182. GNAT_dom.
    [Graphical view ]
    Pfami PF13302. Acetyltransf_3. 1 hit.
    [Graphical view ]
    SUPFAMi SSF55729. SSF55729. 1 hit.
    PROSITEi PS51186. GNAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 39315 / El Tor Inaba N16961Imported.
    2. "X-ray crystal structure of Spermidine n1-acetyltransferase from Vibrio cholerae."
      Osipiuk J., Volkart L., Moy S., Anderson W.F., Joachimiak A.
      Submitted (SEP-2008) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.38 ANGSTROMS) IN COMPLEX WITH MAGNESIUM.
    3. "Dodecameric structure of spermidine N-acetyltransferase from Vibrio cholerae."
      Center for Structural Genomics of Infectious Diseases (CSGID)
      Filippova E.V., Minasov G., Shuvalova L., Kiryukhina O., Kuhn M.L., Anderson W.F.
      Submitted (MAR-2013) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.88 ANGSTROMS).
    4. "Dodecameric structure of spermidine N-acetyltransferase SpeG from Vibrio cholerae O1 biovar eltor."
      Center for Structural Genomics of Infectious Diseases (CSGID)
      Filippova E.V., Minasov G., Shuvalova L., Kiryukhina O., Kuhn M.L., Anderson W.F.
      Submitted (MAR-2013) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.83 ANGSTROMS).
    5. "Crystal structure of spermidine N-acetyltransferase from Vibrio cholerae in complex with spermidine."
      Filippova E.V., Minasov G., Shuvalova L., Kiryukhina O., Kuhn M.L., Anderson W.F.
      Submitted (AUG-2013) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.32 ANGSTROMS).
    6. "Crystal structure of spermidine N-acetyltransferase from Vibrio cholerae in complex with spermine."
      Center for Structural Genomics of Infectious Diseases (CSGID)
      Filippova E.V., Minasov G., Shuvalova L., Kiryukhina O., Kuhn M.L., Anderson W.F.
      Submitted (AUG-2013) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).
    7. "Crystal structure of spermidine N-acetyltransferase from Vibrio cholerae in complex with polyamine."
      Filippova E.V., Minasov G., Shuvalova L., Kiryukhina O., Kuhn M.L., Anderson W.F.
      Submitted (SEP-2013) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (2.04 ANGSTROMS).
    8. "Spermidine N-acetyltransferase from Vibrio cholerae in complex with 2-[n-cyclohexylamino]ethane sulfonate."
      Osipiuk J., Zhou M., Gu M., Anderson W.F., Joachimiak A.
      Submitted (OCT-2013) to the PDB data bank
      Cited for: X-RAY CRYSTALLOGRAPHY (1.89 ANGSTROMS) IN COMPLEX WITH CALCIUM.

    Entry informationi

    Entry nameiQ9KL03_VIBCH
    AccessioniPrimary (citable) accession number: Q9KL03
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2000
    Last sequence update: October 1, 2000
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3