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Protein
Submitted name:

Spermidine n1-acetyltransferase

Gene

VC_A0947

Organism
Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi33 – 331CalciumCombined sources
Metal bindingi33 – 331MagnesiumCombined sources
Metal bindingi75 – 751CalciumCombined sources
Metal bindingi75 – 751MagnesiumCombined sources

GO - Molecular functioni

  1. diamine N-acetyltransferase activity Source: TIGR
  2. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. polyamine catabolic process Source: TIGR
Complete GO annotation...

Keywords - Molecular functioni

TransferaseImported

Keywords - Ligandi

CalciumCombined sources, MagnesiumCombined sources, Metal-bindingCombined sources

Enzyme and pathway databases

BioCyciVCHO:VCA0947-MONOMER.

Names & Taxonomyi

Protein namesi
Submitted name:
Spermidine n1-acetyltransferaseImported
Gene namesi
Ordered Locus Names:VC_A0947Imported
OrganismiVibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)Imported
Taxonomic identifieri243277 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaVibrionalesVibrionaceaeVibrio
ProteomesiUP000000584 Componenti: Chromosome 2

Interactioni

Protein-protein interaction databases

STRINGi243277.VCA0947.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3EG7X-ray2.38A/B/C/D/E/F1-173[»]
4JJXX-ray2.83A/B/C1-173[»]
4JLYX-ray2.88A/B/C/D/E/F1-173[»]
4MHDX-ray2.32A/B/C1-173[»]
4MI4X-ray1.85A/B/C1-173[»]
4MJ8X-ray2.04A/B/C1-173[»]
4NCZX-ray1.89A/B/C1-173[»]
ProteinModelPortaliQ9KL03.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ9KL03.

Family & Domainsi

Phylogenomic databases

KOiK00657.
OMAiAIHIYKK.
OrthoDBiEOG6D5G79.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF13302. Acetyltransf_3. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q9KL03-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNSQLTLRAL ERGDLRFIHN LNNNRNIMSY WFEEPYESFD ELEELYNKHI
60 70 80 90 100
HDNAERRFVV EDAQKNLIGL VELIEINYIH RSAEFQIIIA PEHQGKGFAR
110 120 130 140 150
TLINRALDYS FTILNLHKIY LHVAVENPKA VHLYEECGFV EEGHLVEEFF
160 170
INGRYQDVKR MYILQSKYLN RSE
Length:173
Mass (Da):20,675
Last modified:September 30, 2000 - v1
Checksum:i9821218EFF8E8AD8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003853 Genomic DNA. Translation: AAF96843.1.
PIRiB82398.
RefSeqiNP_233331.1. NC_002506.1.

Genome annotation databases

EnsemblBacteriaiAAF96843; AAF96843; VC_A0947.
GeneIDi2612395.
KEGGivch:VCA0947.
PATRICi20086424. VBIVibCho83274_3559.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE003853 Genomic DNA. Translation: AAF96843.1.
PIRiB82398.
RefSeqiNP_233331.1. NC_002506.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3EG7X-ray2.38A/B/C/D/E/F1-173[»]
4JJXX-ray2.83A/B/C1-173[»]
4JLYX-ray2.88A/B/C/D/E/F1-173[»]
4MHDX-ray2.32A/B/C1-173[»]
4MI4X-ray1.85A/B/C1-173[»]
4MJ8X-ray2.04A/B/C1-173[»]
4NCZX-ray1.89A/B/C1-173[»]
ProteinModelPortaliQ9KL03.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi243277.VCA0947.

Protocols and materials databases

DNASUi2612395.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAF96843; AAF96843; VC_A0947.
GeneIDi2612395.
KEGGivch:VCA0947.
PATRICi20086424. VBIVibCho83274_3559.

Phylogenomic databases

KOiK00657.
OMAiAIHIYKK.
OrthoDBiEOG6D5G79.

Enzyme and pathway databases

BioCyciVCHO:VCA0947-MONOMER.

Miscellaneous databases

EvolutionaryTraceiQ9KL03.

Family and domain databases

Gene3Di3.40.630.30. 1 hit.
InterProiIPR016181. Acyl_CoA_acyltransferase.
IPR000182. GNAT_dom.
[Graphical view]
PfamiPF13302. Acetyltransf_3. 1 hit.
[Graphical view]
SUPFAMiSSF55729. SSF55729. 1 hit.
PROSITEiPS51186. GNAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 39315 / El Tor Inaba N16961Imported.
  2. "X-ray crystal structure of Spermidine n1-acetyltransferase from Vibrio cholerae."
    Osipiuk J., Volkart L., Moy S., Anderson W.F., Joachimiak A.
    Submitted (AUG-2008) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.38 ANGSTROMS) IN COMPLEX WITH MAGNESIUM.
  3. "Dodecameric structure of spermidine N-acetyltransferase from Vibrio cholerae."
    Center for Structural Genomics of Infectious Diseases (CSGID)
    Filippova E.V., Minasov G., Shuvalova L., Kiryukhina O., Kuhn M.L., Anderson W.F.
    Submitted (FEB-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.88 ANGSTROMS).
  4. "Dodecameric structure of spermidine N-acetyltransferase SpeG from Vibrio cholerae O1 biovar eltor."
    Center for Structural Genomics of Infectious Diseases (CSGID)
    Filippova E.V., Minasov G., Shuvalova L., Kiryukhina O., Kuhn M.L., Anderson W.F.
    Submitted (FEB-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.83 ANGSTROMS).
  5. "Crystal structure of spermidine N-acetyltransferase from Vibrio cholerae in complex with spermidine."
    Filippova E.V., Minasov G., Shuvalova L., Kiryukhina O., Kuhn M.L., Anderson W.F.
    Submitted (JUL-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.32 ANGSTROMS).
  6. "Crystal structure of spermidine N-acetyltransferase from Vibrio cholerae in complex with spermine."
    Center for Structural Genomics of Infectious Diseases (CSGID)
    Filippova E.V., Minasov G., Shuvalova L., Kiryukhina O., Kuhn M.L., Anderson W.F.
    Submitted (JUL-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS).
  7. "Crystal structure of spermidine N-acetyltransferase from Vibrio cholerae in complex with polyamine."
    Filippova E.V., Minasov G., Shuvalova L., Kiryukhina O., Kuhn M.L., Anderson W.F.
    Submitted (AUG-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (2.04 ANGSTROMS).
  8. "Spermidine N-acetyltransferase from Vibrio cholerae in complex with 2-[n-cyclohexylamino]ethane sulfonate."
    Osipiuk J., Zhou M., Gu M., Anderson W.F., Joachimiak A.
    Submitted (SEP-2013) to the PDB data bank
    Cited for: X-RAY CRYSTALLOGRAPHY (1.89 ANGSTROMS) IN COMPLEX WITH CALCIUM.

Entry informationi

Entry nameiQ9KL03_VIBCH
AccessioniPrimary (citable) accession number: Q9KL03
Entry historyi
Integrated into UniProtKB/TrEMBL: September 30, 2000
Last sequence update: September 30, 2000
Last modified: January 6, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.