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Reviewed, UniProtKB/Swiss-Prot Q9KKW6 (LLDD_VIBCH)

Last modified November 4, 2008. Version 41. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    L-lactate dehydrogenase [cytochrome]
    EC=1.1.2.3
Gene names
Name: lldD
Ordered Locus Names: VC_A0984
OrganismVibrio cholerae [Complete proteome] [HAMAP]
Taxonomic identifier666 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

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Protein attributes

Sequence length378 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

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General annotation (Comments)

Catalytic activity

(S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c + 2 H(+).

Cofactor

FMN By similarity.

Sequence similarities

Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family.

Contains 1 FMN hydroxy acid dehydrogenase domain.

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Ontologies

Keywords

   LigandFMN
Flavoprotein
   Molecular functionOxidoreductase
   Technical termComplete proteome

Gene Ontology (GO)

   Biological processoxidation reduction

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionL-lactate dehydrogenase (cytochrome) activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 378378L-lactate dehydrogenase [cytochrome]
PRO_0000206352

Regions

Domain1 – 378378FMN hydroxy acid dehydrogenase
Nucleotide binding306 – 33025FMN By similarity

Sites

Active site2751Proton acceptor By similarity
Binding site241Substrate Potential
Binding site1061FMN By similarity
Binding site1271FMN By similarity
Binding site1291Substrate By similarity
Binding site1551FMN By similarity
Binding site1641Substrate By similarity
Binding site2511FMN By similarity
Binding site2781Substrate Potential

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Sequences

Sequence LengthMass (Da)Tools
Q9KKW6-1 [UniParc].

Last modified October 1, 2000. Version 1.
Checksum: 8310DF5B3F217ADC

FASTA37841,291
        10         20         30         40         50         60 
MIISASTDYR AAAKAKLPPF LFHYIDGGSY GEHTLRRNTD DLADIALRQR VLSDMSELSL 

        70         80         90        100        110        120 
ETELFGEKMA LPIALSPVGL TGMYARRGEV QAAQAAEAKG IPFTLSTVSV CPIEEVAPSI 

       130        140        150        160        170        180 
HRPIWFQLYV LKDRGFMKNV LERAKAAGVK NLVFTVDMPV PGARYRDMHS GMSGPNAAMR 

       190        200        210        220        230        240 
RVLQAMAHPS WAWDVGLLGK PHDLGNISKY RGSPTKLEDY IGWLGANFDP SISWKDLEWI 

       250        260        270        280        290        300 
RDFWDGPMII KGILDTEDAK DAVRFGADGI VVSNHGGRQL DGVLSTVQAL PAIADAVKGD 

       310        320        330        340        350        360 
LKILVDSGIR TGLDVVRMLA LGADCTMLGR SFIYALAAQG RAGVENLLDL YEKEMRVAMT 

       370 
LTGAKSIAEL SRDSLVKR

« Hide

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Cross-references

Sequence databases

AE003853 Genomic DNA. Translation: AAF96880.1.
PIRB82392.
RefSeqNP_233368.1.

3D structure databases

HSSPHSSP built from PDB template 1LTD based on UniProtKB P00175.
ModBaseSearch...

Genome annotation databases

GeneID2612817.
GenomeReviewsGene locus VC_A0984 in contig AE003853_GR.
KEGGvch:VCA0984.
TIGRVC_A0984.

Phylogenomic databases

HOGENOMQ9KKW6.

Family and domain databases

HAMAPMF_01559.
[Tree]
InterProIPR013785. Aldolase_TIM.
IPR012133. Alpha_OHA_DHase_FMN.
IPR008259. FMN_hydac_DHase_AS.
IPR000262. FMN_OHA_DHase.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PfamPF01070. FMN_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000138. Al-hdrx_acd_dh. 1 hit.
PROSITEPS00557. FMN_HYDROXY_ACID_DH_1. 1 hit.
PS51349. FMN_HYDROXY_ACID_DH_2. 1 hit.
[Graphical view]
BLOCKSSearch...
ProtoNetSearch...

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Entry information

Entry nameLLDD_VIBCH
AccessionPrimary (citable) accession number: Q9KKW6
Entry history
Integrated into UniProtKB/Swiss-Prot: January 10, 2006
Last sequence update: October 1, 2000
Last modified: November 4, 2008
This is version 41 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

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Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents