Reviewed, UniProtKB/Swiss-Prot Q9KKQ6 (MTLD_VIBCH)

Names and origin

Protein names

Recommended name:
    Mannitol-1-phosphate 5-dehydrogenase
    EC=1.1.1.17

Gene names

Name:	mtlD
Ordered Locus Names:	VC_A1046

Organism

Vibrio cholerae [Complete proteome] [HAMAP]

Taxonomic identifier

666 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Vibrionales › Vibrionaceae › Vibrio

Protein attributes

Sequence length	384 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH. HAMAP MF_00196
Sequence similarities	Belongs to the mannitol dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	coenzyme binding Inferred from electronic annotation. Source: InterPro mannitol-1-phosphate 5-dehydrogenase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 384	384	Mannitol-1-phosphate 5-dehydrogenase HAMAP MF_00196		PRO_0000170729
Regions
	Nucleotide binding	5 – 16	12	NAD By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q9KKQ6-1 [UniParc]. Last modified October 1, 2000. Version 1. Checksum: 60D4F90913EF186D	FASTA	384	42,340
	10 20 30 40 50 60 MKKNAVHFGA GNIGRGFIGK LLADADIAVT FADVNEPLVD QLSHQQEYKV KVVGSECKME 70 80 90 100 110 120 TVSHVTAVNS ASEALIERII KTDLVTTAVG PTVLDIIAKT IAKGLSARFA AGNTQPLNII 130 140 150 160 170 180 ACENMVRGTT HLKQQVYQFL TTEEQQQADA LVGFVDSAVD RIVPPLQAAN DDPLEVTVES 190 200 210 220 230 240 FSEWIVDEQQ FKGEIPQIEG MEKTDNLMAF VERKLFTLNT GHCVTAYLGC LKGHRTIREA 250 260 270 280 290 300 IEDPCIHAQV KQAMQESGEV LIRRYGFDRA LHSAYIEKIL SRFANPYLVD EVDRVGRQPL 310 320 330 340 350 360 RKLSANDRLI KPLLGTIEYG LPNGMLLKGI AAALKYRNSS DPQAVELQQS IEKEGVRSTL 370 380 ARYTGLAAES VEAQQIEALY QQMD

References

[1]

"DNA sequence of both chromosomes of the cholera pathogen Vibrio cholerae." Heidelberg J.F., Eisen J.A., Nelson W.C., Clayton R.A., Gwinn M.L., Dodson R.J., Haft D.H., Hickey E.K., Peterson J.D., Umayam L.A., Gill S.R., Nelson K.E., Read T.D., Tettelin H., Richardson D.L., Ermolaeva M.D., Vamathevan J.J., Bass S. , Qin H., Dragoi I., Sellers P., McDonald L.A., Utterback T.R., Fleischmann R.D., Nierman W.C., White O., Salzberg S.L., Smith H.O., Colwell R.R., Mekalanos J.J., Venter J.C., Fraser C.M. Nature 406:477-483(2000) [PubMed: 10952301] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 39315 / El Tor Inaba N16961 / Serotype O1.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE003853 Genomic DNA. Translation: AAF96940.1.
PIR	C82385.
RefSeq	NP_233428.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	2612121.
GenomeReviews	Gene locus VC_A1046 in contig AE003853_GR.
KEGG	vch:VCA1046.
TIGR	VC_A1046.
Phylogenomic databases
HOGENOM	Q9KKQ6.
OMA	Q9KKQ6. VDRIVPN.
Enzyme and pathway databases
BRENDA	1.1.1.17. 19019.
Family and domain databases
HAMAP	MF_00196. [Tree]
InterPro	IPR013328. DH_multihelical. IPR013118. Mannitol_DH_C. IPR000669. Mannitol_DH_core. IPR013131. Mannitol_DH_N. IPR016040. NAD(P)-bd_dom. [Graphical view]
Gene3D	G3DSA:3.40.50.720. NAD(P)-bd. 1 hit. G3DSA:1.10.1040.10. Opine_DH. 1 hit.
Pfam	PF01232. Mannitol_dh. 1 hit. PF08125. Mannitol_dh_C. 1 hit. [Graphical view]
PRINTS	PR00084. MTLDHDRGNASE.
PROSITE	PS00974. MANNITOL_DHGENASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MTLD_VIBCH

Accession

Primary (citable) accession number: Q9KKQ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 19, 2002
Last sequence update:	October 1, 2000
Last modified:	June 16, 2009
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)